Bookmark and Share
MLS001215245 (CID 16399878) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(23)
 
 
Inactive(514)
 
 
Inconclusive(11)
 
 
Unspecified(9)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
7TM GPCR Srsx(15)
 
 
Death TRAILR..(12)
 
 
 
 
PAX(8)
 
 
 
 
TRP 2(5)
 
 
BioAssay Types:
Screening(388)
 
 
 
 
 
Confirmatory(160)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(116)
 
 
 
 
 
IC50(27)
 
 
AC50(9)
 
 
 
 
EC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 503    Data Row: 557   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49645784]
Potency 5.6234qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator precursor [Mus musculus] [gi:6679377]
View
2
[SID49645784]
Potency 5.6234qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase plasminogen activator surface receptor precursor [Mus musculus] [gi:7242179]
View
3
[SID49645784]
Potency 5.6234qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]plasminogen precursor [Mus musculus] [gi:257471003]
View
4
[SID49645784]
Potency 8.2753Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
View
5
[SID165222626]
AC50_uM 9.73SA12 PAX8: cytotoxicity COV362 Measured in Cell-Based System Using Plate Reader - 7054-16_Inhibitor_Dose_DryPowder_Activity [AID743144, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
View
6
[SID165222626]
AC50_uM 10.29SA11 PAX8: cytotoxicity OVCAR4 Measured in Cell-Based System Using Plate Reader - 7054-13_Inhibitor_Dose_DryPowder_Activity [AID743150, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
View
7
[SID49645784]
AC50_uM 10.35HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity [AID687027, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
View
8
[SID49645784]
Potency 13.1154Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
View
9
[SID49645784]
Potency 14.581qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
10
[SID165222626]
AC50_uM 21.4SA7-Pax8: cytotoxicity COV434 Measured in Cell-Based System Using Plate Reader - 7054-09_Inhibitor_Dose_DryPowder_Activity [AID743145, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
View
11
[SID49645784]
Counterscreen for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS): Luminescence-based cell-based high throughput assay to identify compounds that are cytotoxic to Jurkat human T lymphocyte cells [AID624413, Type: screening]
View
12
[SID49645784]
Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16) [AID588794, Type: screening]transactivating tegument protein VP16 [Human herpesvirus 1] [gi:9629429]
View
13
[SID49645784]
Counterscreen for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1): Luminescence-based cell-based high throughput assay to identify inhibitors of the Herpes Virus Virion Protein 16 (VP16). [AID588824, Type: screening]transactivating tegument protein VP16 [Human herpesvirus 1] [gi:9629429]
View
14
[SID49645784]
Full deck counterscreen for agonists of the human M1 muscarinic receptor (CHRM1): Fluorescence-based cell-based high throughput screening assay to identify nonselective activators and assay artifacts using the parental CHOK1 cell line [AID602248, Type: screening]
View
15
[SID49645784]
HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS [AID485317, Type: screening]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
View
16
[SID49645784]
Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) [AID624268, Type: screening]methionyl-tRNA synthetase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:71746704]
View
17
[SID49645784]
Luminescence-based biochemical high throughput confirmation assay for inhibitors of Trypanosoma brucei methionyl tRNA synthetase (MetRS) [AID624412, Type: screening]methionyl-tRNA synthetase [Trypanosoma brucei brucei strain 927/4 GUTat10.1] [gi:71746704]
View
18
[SID49645784]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
View
19
[SID49645784]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
View
20
[SID49645784]
HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_SinglePoint_HTS_Activity [AID652154, Type: screening]PAX8 [Homo sapiens] [gi:998701]
View
21
[SID49645784]
uHTS identification of Caspase-8 TRAIL sensitizers in a luminesence assay [AID624354, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
View
22
[SID49645784]
Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
View
23
[SID49645784]
Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_1, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
View
24
[SID49645784]
Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_2, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
View
25
[SID49645784]
Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_3, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
View
26
[SID49645784]
Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_4, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
View
27
[SID49645784]
Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_5, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
View
28
[SID49645784]
Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_7, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
View
29
[SID49645784]
Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_8, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
View
30
[SID49645784]
Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_9, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
View
31
[SID49645784]
Single concentration confirmation of Caspase-8 TRAIL sensitizer hits in a luminesence panel assay [AID651596_10, Type: screening]tumor necrosis factor receptor superfamily member 10B isoform 1 precursor [Homo sapiens] [gi:224494019]
View
32
[SID49645784]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
View
33
[SID49645784]
Potency 10qHTS for Activators of Integrin-Mediated Alleviation for Muscular Dystrophy [AID624291, Type: confirmatory]Glycoprotein hormones alpha chain [gi:121312]
View
34
[SID165222626]
AC50_uM 100SA8-Pax8: cytotoxicity OV-90 Measured in Cell-Based System Using Plate Reader - 7054-10_Inhibitor_Dose_DryPowder_Activity [AID743149, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
View
35
[SID49645784]
AC50_uM PAX8: PAX8-dependent cytoxicity Measured in Cell-Based System Using Plate Reader - 7054-06_Inhibitor_Dose_CherryPick_Activity [AID687029, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
View
36
[SID49645784]
Potency qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
View
37
[SID49645784]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ CIT2_MLPCN. [AID2029, Type: screening]citrate synthase 2, partial [Saccharomyces cerevisiae] [gi:171229]
View
38
[SID49645784]
Potency Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS [AID504937, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
View
39
[SID49645784]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ LAP4_MLPCN. [AID2023, Type: screening]LAP4 [Saccharomyces cerevisiae] [gi:486173]
View
40
[SID49645784]
Primary cell-based high-throughput screening assay for identification of compounds that protect hERG from block by proarrhythmic agents [AID1511, Type: screening]putative potassium channel subunit [Homo sapiens] [gi:487738]
View
41
[SID49645784]
Potency qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
View
42
[SID49645784]
Primary biochemical high throughput screening assay to identify inhibitors of BCL2-related protein, long isoform (BCLXL). [AID2129, Type: screening]bcl-xL [Homo sapiens] [gi:510901]
View
43
[SID49645784]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_ RPL19A_MLPCN. [AID2025, Type: screening]RPL19A [Saccharomyces cerevisiae] [gi:536029]
View
44
[SID49645784]
Potency Activators of T cell receptors: qHTS campaign [AID504894, Type: confirmatory]T cell receptor [Homo sapiens] [gi:553160]
View
45
[SID49645784]
Potency qHTS of alpha-syn Inhibitors [AID652106, Type: confirmatory]Alpha-synuclein [gi:586067]
View
46
[SID49645784]
Potency qHTS of Nrf2 Activators [AID624171, Type: confirmatory]Nrf2 [Homo sapiens] [gi:693842]
View
47
[SID49645784]
Fluorescence Cell-Based Primary HTS of C.albicans growth in the presence of Fluconazole and compound [AID1979, Type: screening]heat shock protein 90 [Candida albicans] [gi:994798]
View
48
[SID49645784]
Potency qHTS of GLP-1 Receptor Inverse Agonists: Cytotox Screen [AID624418, Type: confirmatory]
View
49
[SID49645784]
Heat Shock Factor-1 (HSF-1) Measured in Cell-Based System Using Plate Reader - 2038-01_Activator_SinglePoint_HTS_Activity [AID504408, Type: screening]
View
50
[SID49645784]
Potency Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
View