MLS001214216 (CID 16396239) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(25)
 
 
Inactive(432)
 
 
Inconclusive(11)
 
 
Unspecified(10)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
PP1c bdg(12)
 
 
 
 
FA58C(7)
 
 
 
 
7TM GPCR Srsx(6)
 
 
 
Gp dh C(6)
 
 
 
 
BioAssay Types:
Screening(316)
 
 
 
Confirmatory(153)
 
 
 
 
 
Literature(5)
 
 
 
BioActivity Types:
Potency(99)
 
 
 
 
 
IC50(43)
 
 
 
 
EC50(4)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 460    Data Row: 478   Total Pages: 10   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID49648713]
IC50 1.598Dose Response confirmation of uHTS small molecule Peg3 Promoter Inhibitor hits in screening - selectivity counter screen assays - Set 2 [AID651549_3, Type: confirmatory]Ppp1r15a gene product [Rattus norvegicus] [gi:78486550]
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2
[SID49648713]
AbsAC35_uM 2.85Counterscreen for inhibitors of NLG for Luciferase Activators Measured in Cell-Based System Using Plate Reader - 2146-03_Inhibitor_Dose_CherryPick_Activity [AID624404, Type: confirmatory]
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3
[SID49648713]
Potency 5.1735Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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4
[SID49648713]
Potency 5.1735Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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5
[SID49648713]
Potency 5.1735Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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6
[SID49648713]
Potency 5.1735Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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7
[SID49648713]
IC50 6.509Dose Response confirmation of uHTS small molecule Peg3 Promoter Inhibitor hits in screening - selectivity counter screen assays - Set 2 [AID651549_1, Type: confirmatory]Glyceraldehyde-3-phosphate dehydrogenase [gi:120649]
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8
[SID49648713]
Potency 10qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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9
[SID49648713]
CC50 13.5A Cell Based Secondary Assay To Explore Cytotoxicity of West Nile Virus Anti-Viral Hit Compounds [AID1650, Type: confirmatory]
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10
[SID49648713]
Potency 14.575qHTS screen for small molecules that inhibit ELG1-dependent DNA repair in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504467, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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11
[SID49648713]
Potency 14.581qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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12
[SID49648713]
CC50 18.54Vero 76 Cytoxicity Assay for VEEV Compounds [AID588719, Type: confirmatory]
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13
[SID49648713]
Potency 25.929qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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14
[SID49648713]
 MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - inhibitors [AID1813, Type: screening]
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15
[SID49648713]
 Luminescence-based cell-based primary high throughput screening assay to identify activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM) [AID652017, Type: screening]
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16
[SID49648713]
 uHTS identification of modulators of interaction between CendR and NRP-1 using Fluorescence Polarization assay [AID602438, Type: screening]Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin- 1 [gi:160877737]
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17
[SID49648713]
 Fluorescence-based cell-based primary high throughput confirmation assay to identify antagonists of the Galanin Receptor 3 (GalR3) [AID652245, Type: screening]
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18
[SID49648713]
 Counterscreen for antagonists of the galanin Receptor 3 (GalR3): Fluorescence-based cell-based high throughput screening assay to identify non specific agonists of the parental HEK-CNG cells [AID652268, Type: screening]
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19
[SID49648713]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504905, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
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20
[SID49648713]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504905, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
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21
[SID49648713]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504905, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
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22
[SID49648713]
 Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R [AID540308, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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23
[SID49648713]
 Luminescence-based cell-based primary high throughput screening assay to identify biased ligands of the melanocortin 4 receptor (MC4R): agonists of MC4R [AID540308, Type: screening]melanocortin receptor 4 [Homo sapiens] [gi:119508433]
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24
[SID49648713]
IC50 Dose Response confirmation of uHTS small molecule Peg3 Promoter Inhibitor hits in a screening assay [AID624167_1, Type: confirmatory]Glyceraldehyde-3-phosphate dehydrogenase [gi:120649]
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25
[SID49648713]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD2 [AID1566, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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26
[SID49648713]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD2 [AID1566, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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27
[SID49648713]
EC50 uHTS luminescence assay for the identification of compounds that inhibit NOD2 [AID1566, Type: confirmatory]nucleotide-binding oligomerization domain-containing protein 2 [Homo sapiens] [gi:11545912]
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28
[SID49648713]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504692, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
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29
[SID49648713]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504692, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
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30
[SID49648713]
 Counterscreen for agonists of OPRM1-OPRD1 heterodimerization: luminescence-based cell-based full-deck high throughput screening assay to identify agonists of 5-hydroxytryptamine (serotonin) 5A receptor (HTR5A) [AID504692, Type: screening]HTR5A gene product [Homo sapiens] [gi:13236497]
View
31
[SID49648713]
 Luminescence-based cell-based primary high throughput screening assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504326, Type: screening]OPRD1 gene product [Homo sapiens] [gi:63477962]
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32
[SID49648713]
 Luminescence-based cell-based primary high throughput screening assay to identify agonists of heterodimerization of the mu 1 (OPRM1) and delta 1 (OPRD1) opioid receptors [AID504326, Type: screening]OPRD1 gene product [Homo sapiens] [gi:63477962]
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33
[SID49648713]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the Galanin Receptor 3 (GalR3) [AID651719, Type: screening]GALR3 gene product [Homo sapiens] [gi:4503907]
View
34
[SID49648713]
 Fluorescence-based cell-based primary high throughput screening assay to identify antagonists of the Galanin Receptor 3 (GalR3) [AID651719, Type: screening]GALR3 gene product [Homo sapiens] [gi:4503907]
View
35
[SID49648713]
IC50 Dose Response confirmation of uHTS small molecule Peg3 Promoter Inhibitor hits in a screening assay [AID624167_4, Type: confirmatory]Ppp1r15a gene product [Rattus norvegicus] [gi:78486550]
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36
[SID49648713]
 HTS Assay for Peg3 Promoter Inhibitors [AID588405, Type: screening]Ppp1r15a gene product [Rattus norvegicus] [gi:78486550]
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37
[SID49648713]
 Single concentration confirmation of uHTS hits for Peg3 Promoter Inhibitors via a luciferase reporter assay [AID602417, Type: screening]Ppp1r15a gene product [Rattus norvegicus] [gi:78486550]
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38
[SID49648713]
IC50 95Dose Response confirmation of small molecule modulators of the interaction between CendR and NRP-1 in a panel assay [AID651650_2, Type: confirmatory]Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin- 1 [gi:160877737]
View
39
[SID49648713]
IC50 95Dose Response confirmation of small molecule modulators of the interaction between CendR and NRP-1 in a panel assay [AID651650_3, Type: confirmatory]Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin- 1 [gi:160877737]
View
40
[SID49648713]
IC50 100Dose Response confirmation of small molecule modulators of the interaction between CendR and NRP-1 in a panel assay [AID651650_5, Type: confirmatory]Chain A, Crystal Structure Of The B1b2 Domains From Human Neuropilin- 1 [gi:160877737]
View
41
[SID49648713]
IC50 Dose Response confirmation of uHTS small molecule Peg3 Promoter Inhibitor hits in a screening assay [AID624167_2, Type: confirmatory]Glyceraldehyde-3-phosphate dehydrogenase [gi:120649]
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42
[SID49648713]
IC50 Dose Response confirmation of uHTS small molecule Peg3 Promoter Inhibitor hits in a screening assay [AID624167_3, Type: confirmatory]Glyceraldehyde-3-phosphate dehydrogenase [gi:120649]
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43
[SID49648713]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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44
[SID49648713]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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45
[SID49648713]
IC50 Dose Response confirmation of uHTS small molecule Peg3 Promoter Inhibitor hits in a screening assay [AID624167_8, Type: confirmatory]Ppp1r15a gene product [Rattus norvegicus] [gi:78486550]
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46
[SID49648713]
IC50 Dose Response confirmation of uHTS small molecule Peg3 Promoter Inhibitor hits in a screening assay [AID624167_9, Type: confirmatory]Ppp1r15a gene product [Rattus norvegicus] [gi:78486550]
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47
[SID49648713]
IC50 Dose Response confirmation of uHTS small molecule Peg3 Promoter Inhibitor hits in a screening assay [AID624167_5, Type: confirmatory]Ppp1r15a gene product [Rattus norvegicus] [gi:78486550]
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48
[SID49648713]
IC50 Dose Response confirmation of uHTS small molecule Peg3 Promoter Inhibitor hits in a screening assay [AID624167_6, Type: confirmatory]Ppp1r15a gene product [Rattus norvegicus] [gi:78486550]
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49
[SID49648713]
IC50 10.4Dose Response confirmation of uHTS small molecule Peg3 Promoter Inhibitor hits in a screening assay [AID624167, Type: confirmatory]Ppp1r15a gene product [Rattus norvegicus] [gi:78486550]
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50
[SID49648713]
IC50 11.062Dose Response confirmation of uHTS small molecule Peg3 Promoter Inhibitor hits in screening - selectivity counter screen assays - Set 2 [AID651549_4, Type: confirmatory]Ppp1r15a gene product [Rattus norvegicus] [gi:78486550]
View