MLS000863596 (CID 16376440) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(54)
 
 
Inactive(452)
 
 
Inconclusive(34)
 
 
Unspecified(3)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
 
Tryp SPc(7)
 
 
 
alkPPc(6)
 
 
 
7TM GPCR Srsx(6)
 
 
G-alpha(6)
 
 
 
 
BioAssay Types:
Screening(363)
 
 
 
 
Confirmatory(165)
 
 
 
 
 
Literature(9)
 
 
 
 
BioActivity Types:
Potency(115)
 
 
 
 
 
IC50(35)
 
 
 
 
EC50(8)
 
 
 
AC50(2)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 543    Data Row: 543   Total Pages: 11   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26657808]
AC50 0.641MLPCN Dyrk1A Kinase Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_Dose_CherryPick_Activity [AID588345, Type: confirmatory]dual specificity tyrosine-phosphorylation-regulated kinase 1A [Rattus norvegicus] [gi:6978787]
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2
[SID26657808]
AC50 0.641MLPCN Dyrk1A Kinase Measured in Biochemical System Using Plate Reader - 2124-01_Inhibitor_Dose_CherryPick_Activity [AID588345, Type: confirmatory]dual specificity tyrosine-phosphorylation-regulated kinase 1A [Rattus norvegicus] [gi:6978787]
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3
[SID26657808]
Potency 3.1623qHTS Assay for NPC1 Promoter Activators [AID485313, Type: confirmatory]NPC1 gene product [Homo sapiens] [gi:255652944]
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4
[SID26657808]
Potency 3.9811qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]RAB9A gene product [Homo sapiens] [gi:4759012]
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5
[SID26657808]
Potency 5.2119qHTS Assay for Modulators of miRNAs and/or Inhibitors of miR-21 [AID2289, Type: confirmatory]
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6
[SID26657808]
Potency 6.3096qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator [Mus musculus] [gi:6679377]
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7
[SID26657808]
Potency 6.3096qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator [Mus musculus] [gi:6679377]
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8
[SID26657808]
Potency 8.4921qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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9
[SID26657808]
EC50 12.4Luminescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of Glycogen Synthase Kinase-3 beta Activity [AID434954, Type: confirmatory]GSK3B gene product [Homo sapiens] [gi:21361340]
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10
[SID26657808]
EC50 12.4Luminescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of Glycogen Synthase Kinase-3 beta Activity [AID434954, Type: confirmatory]GSK3B gene product [Homo sapiens] [gi:21361340]
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11
[SID26657808]
EC50 12.4Luminescence Cell-Free Homogeneous Dose Retest to Identify Inhibitors of Glycogen Synthase Kinase-3 beta Activity [AID434954, Type: confirmatory]GSK3B gene product [Homo sapiens] [gi:21361340]
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12
[SID26657808]
Potency 23.0999qHTS screen for small molecules that induce genotoxicity in human embryonic kidney (HEK293T) cells expressing luciferase-tagged ELG1 [AID504466, Type: confirmatory]ATAD5 protein [Homo sapiens] [gi:116283940]
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13
[SID26657808]
IC50 26.05Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens [AID624330, Type: confirmatory]RACGAP1 gene product [Homo sapiens] [gi:21361397]
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14
[SID26657808]
Potency 28.1838qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624287, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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15
[SID26657808]
IC50 33.86Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Counter Screen Coupled Enzyme [AID624351, Type: confirmatory]
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16
[SID103599609]
IC50 34.6Growth inhibition of mouse Hepa-1c1c7 cells [AID355762, Type: Literature]
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17
[SID26657808]
Potency 79.4328Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) - Round 2 Cherry Picks [AID504841, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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18
[SID26657808]
 Luminescence-based cell-based primary high throughput screening assay for inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1): repression of SF-1 (NR5A1) activated StAR promoter by full-length DAX-1 [AID652010, Type: screening]NR0B1 gene product [Homo sapiens] [gi:5016090]
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19
[SID26657808]
 Luminescence-based primary cell-based high throughput screening assay to identify inhibitors of the orphan nuclear receptor subfamily 0, group B, member 1 (DAX1; NR0B1) [AID504766, Type: screening]NR0B1 gene product [Homo sapiens] [gi:5016090]
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20
[SID26657808]
 Luminescence-based cell-based primary high throughput screening assay to identify activators of the GAA850 frataxin (FXN) promoter [AID540364, Type: screening]
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21
[SID26657808]
 Counterscreen for activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM): Luminescence-based cell-based high throughput screening assay to identify non-selective compounds using the VP16 reporter assay [AID686939, Type: screening]
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22
[SID26657808]
 Counterscreen for activators of kallikrein-7 (K7) zymogen: Fluorescence intensity-based biochemical high throughput counterscreen assay for activators that optically interfere with measurement of EDANS-DABCYL fluorescence [AID686952, Type: screening]
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23
[SID26657808]
 Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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24
[SID26657808]
 A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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25
[SID26657808]
 Counterscreen for activators of the GAA850 frataxin promoter: luminescence-based cell-based high throughput screening assay to identify activators of the GAA30 frataxin promoter [AID588350, Type: screening]
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26
[SID26657808]
 Luminescence-based cell-based high throughput confirmation assay for activators of the GAA850 frataxin (FXN) promoter [AID588351, Type: screening]
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27
[SID85843928]
 Luminescence Homogenous Primary HTS to Identify Inhibitors of STK33 Activity [AID2322, Type: screening]
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28
[SID26657808]
 HTS to identify inhibitors of zVAD Induced Cell Death in L929 Cells. [AID1377, Type: screening]
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29
[SID26657808]
 MLPCN Alpha-Synuclein 5'UTR - 5'-UTR binding - activators [AID1814, Type: screening]
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30
[SID26657808]
IC50 uHTS identification of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb-SMMHC via a fluorescence resonance energy transfer (FRET) assay. [AID1434, Type: confirmatory]core-binding factor subunit beta isoform 1 [Homo sapiens] [gi:13124881]
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31
[SID26657808]
IC50 uHTS identification of compounds inhibiting the binding between the RUNX1 Runt domain and CBFb-SMMHC via a fluorescence resonance energy transfer (FRET) assay. [AID1434, Type: confirmatory]core-binding factor subunit beta isoform 1 [Homo sapiens] [gi:13124881]
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32
[SID26657808]
 uHTS Luminescent assay for identification of inhibitors of human intestinal alkaline phosphatase [AID2544, Type: screening]Alkaline phosphatase, intestinal [Homo sapiens] [gi:124376142]
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33
[SID26657808]
 uHTS Luminescent assay for identification of inhibitors of human intestinal alkaline phosphatase [AID2544, Type: screening]Alkaline phosphatase, intestinal [Homo sapiens] [gi:124376142]
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34
[SID26657808]
 uHTS identification of agonists of the CRF-binding protein and CRF-R2 receptor complex [AID588473, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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35
[SID26657808]
 uHTS identification of agonists of the CRF-binding protein and CRF-R2 receptor complex [AID588473, Type: screening]corticotropin releasing factor-binding protein [Homo sapiens] [gi:30219]
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36
[SID26657808]
 Allosteric Agonists of the Human D1 Dopamine Receptor: qHTS [AID504660, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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37
[SID26657808]
 Allosteric Agonists of the Human D1 Dopamine Receptor: qHTS [AID504660, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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38
[SID26657808]
 Allosteric Agonists of the Human D1 Dopamine Receptor: qHTS [AID504660, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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39
[SID26657808]
 Allosteric Agonists of the Human D1 Dopamine Receptor: qHTS [AID504660, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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40
[SID26657808]
 Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput screening assay to identify agonists of the vasopressin 1 receptor (V1R), in triplicate [AID434991, Type: screening]vasopressin V1a receptor [Homo sapiens] [gi:4502331]
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41
[SID26657808]
 Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput screening assay to identify agonists of the vasopressin 1 receptor (V1R), in triplicate [AID434991, Type: screening]vasopressin V1a receptor [Homo sapiens] [gi:4502331]
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42
[SID26657808]
 Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based cell-based high throughput screening assay to identify agonists of the vasopressin 1 receptor (V1R), in triplicate [AID434991, Type: screening]vasopressin V1a receptor [Homo sapiens] [gi:4502331]
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43
[SID26657808]
 HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS [AID485317, Type: screening]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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44
[SID26657808]
 Fluorescence polarization-based cell-based high throughput confirmation assay for inhibitors of insulin-degrading enzyme (IDE) [AID435028, Type: screening]IDE gene product [Homo sapiens] [gi:155969707]
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45
[SID26657808]
 Fluorescence polarization-based cell-based primary high throughput screening assay to identify inhibitors of insulin-degrading enzyme (IDE) [AID434962, Type: screening]IDE gene product [Homo sapiens] [gi:155969707]
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46
[SID26657808]
 FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID485270, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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47
[SID26657808]
 FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID485270, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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48
[SID26657808]
 Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of GSK-3 alpha [AID2650, Type: screening]GSK3A gene product [Homo sapiens] [gi:49574532]
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49
[SID26657808]
 Luminescence Cell-Free Homogenous Primary HTS to Identify Inhibitors of GSK-3 alpha [AID2650, Type: screening]GSK3A gene product [Homo sapiens] [gi:49574532]
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50
[SID26657808]
 Fluorescence-based primary cell-based high throughput screening assay to identify agonists of the Oxytocin Receptor (OXTR). [AID2435, Type: screening]oxytocin receptor [Homo sapiens] [gi:32307152]
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