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Pimozide (CID 16362) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(223)
 
 
Inactive(1407)
 
 
Inconclusive(278)
 
 
Unspecified(113)
 
 
Top Targets:
7TM GPCR Srx(38)
 
 
 
 
p450(35)
 
 
 
 
 
7TM GPCR Srsx(30)
 
 
 
 
NR LBD PPAR(27)
 
 
 
 
NR LBD TR(24)
 
 
 
 
BioAssay Types:
Confirmatory(971)
 
 
 
 
 
Screening(639)
 
 
 
 
Literature(219)
 
 
 
 
 
Summary(49)
 
 
 
 
BioActivity Types:
Potency(775)
 
 
 
 
 
IC50(88)
 
 
 
 
 
EC50(13)
 
 
 
Ki(7)
 
 
 
AC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1355    Data Row: 2021   Total Pages: 41   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103503415]
IC50 0.0004Inhibition of [3H]haloperidol binding to dopamine receptors in rat striatal membranes. [AID62722, Type: Literature]
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2
[SID103503415]
Ki 0.0005Binding affinity towards rat 5-hydroxytryptamine 7 receptor [AID6648, Type: Literature]
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3
[SID103503415]
Ki 0.0006Binding affinity of compound towards Dopamine receptor D2 using [3H]raclopride (1.2 nM) ligand in striatum bovine was determined [AID62330, Type: Literature]
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4
[SID103503415]
IC50 0.00302Inhibition of human ERG channel in HEK293 cells by voltage-clamp method [AID392051, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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5
[SID103503415]
Ki 0.012Binding affinity towards Dopamine receptor D2 [AID64143, Type: Literature]
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6
[SID103503415]
IC50 0.018K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1 [AID82355, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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7
[SID103503415]
IC50 0.018Inhibition of K+ channel activity in CHO cells expressing HERG Kv11.1 [AID161283, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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8
[SID103503415]
IC50 0.018Inhibitory activity against Potassium channel HERG [AID161284, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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9
[SID103503415]
IC50 0.0182Inhibition of human ERG in MCF7 cells [AID420668, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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10
[SID103503415]
Kd 0.029Inhibition of dopamine D2 receptor [AID499463, Type: Literature]
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11
[SID103503415]
Kd 0.04Inhibition of T-type alpha1G calcium channel [AID549672, Type: Literature]
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12
[SID103503415]
Ki 0.042Displacement of [3H]Astemizole from hERG expressed in HEK293 cells at 10 uM [AID274128, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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13
[SID103503415]
IC50 0.05012Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique [AID408340, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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14
[SID103503415]
IC50 0.05012Inhibition of human Potassium channel HERG expressed in mammalian cells [AID161281, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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15
[SID103503415]
IC50 0.05012Inhibitory concentration against potassium channel HERG [AID243151, Type: Literature]
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16
[SID103503415]
IC50 0.0546Inhibition of human ERG channel [AID397743, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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17
[SID103503415]
IC50 0.05495Inhibition of human ERG [AID576612, Type: Literature]Potassium voltage-gated channel subfamily H member 2 [gi:7531135]
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18
[SID50104653]
Potency 0.0562qHTS Assay for Small Molecule Inhibitors of the Human hERG Channel Activity [AID588834, Type: Literature]potassium voltage-gated channel subfamily H member 2 isoform d [Homo sapiens] [gi:325651834]
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19
[SID103503415]
Ki 0.071Binding affinity towards human 5-hydroxytryptamine 6 receptor [AID6563, Type: Literature]
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20
[SID103503415]
IC50 0.34Inhibitory activity against type IIA sodium channel in CNaIIA-1 cell line expressed in CHO cells [AID215805, Type: Literature]
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21
[SID103503415]
IC50 0.372Binding affinity against mu opioid receptor using [3H]DAMGO [AID152237, Type: Literature]Mu-type opioid receptor [gi:2851402]
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22
[SID103503415]
IC50 0.8Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCEC [AID150755, Type: Literature]
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23
[SID103503415]
IC50 0.99Binding affinity against opioid receptor kappa 1 by using [3H]U-69593 as radioligand [AID147857, Type: Literature]
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24
[SID103503415]
IC50 1.7Inhibitory concentration against IKr potassium channel [AID240820, Type: Literature]
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25
[SID56422165]
Potency 1.9953qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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26
[SID855710]
IC50 2.171High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1626, Type: confirmatory]
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27
[SID103503415]
IC50 2.51189Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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28
[SID855710]
Potency 2.5119qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapiens] [gi:32879895]
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29
[SID855710]
Potency 2.6169Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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30
[SID50104653]
Potency 2.8184qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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31
[SID103503415]
IC50 2.9Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay [AID150752, Type: Literature]
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32
[SID103503415]
IC50 3.16228Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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33
[SID50104653]
Potency 3.1623qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 3D7 [AID1876, Type: confirmatory]
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34
[SID11112507]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2D6 [AID891, Type: confirmatory]cytochrome P450 2D6 isoform 1 [Homo sapiens] [gi:40805836]
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35
[SID11113804]
Potency 3.1623qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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36
[SID50104653]
Potency 3.1623qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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37
[SID103503415]
IC50 3.76Binding affinity against delta opiate receptor using [3H]DPDPE [AID148075, Type: Literature]Delta-type opioid receptor [gi:311033488]
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38
[SID56422165]
AC50_uM 3.785Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Cancer Stem Cells [AID449748, Type: confirmatory]
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39
[SID103503415]
IC50 3.98107Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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40
[SID50104653]
Potency 3.9811qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
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41
[SID103503415]
IC50 4.9Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay [AID150753, Type: Literature]
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42
[SID103503415]
IC50 5.01187Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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43
[SID11112507]
Potency 5.0119qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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44
[SID11111615]
Potency 5.0119qHTS Assay for Identification of Small Molecule Antagonists for Hypoxia Response Element Signaling Pathway [AID915, Type: confirmatory]hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) [Homo sapiens] [gi:32879895]
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45
[SID144203775]
Potency-Replicate_1 5.308qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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46
[SID144211903]
Potency-Replicate_1 5.4483qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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47
[SID144211903]
Potency-Replicate_1 5.4941qHTS assay to identify small molecule antagonists of the glucocorticoid receptor (GR) signaling pathway - cell viability counter screen [AID720693, Type: confirmatory]
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48
[SID50104653]
Potency 5.6234qHTS for differential inhibitors of proliferation of Plasmodium falciparum line HB3 [AID1886, Type: confirmatory]
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49
[SID104171210]
Potency 6.012Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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50
[SID144211903]
Potency-Replicate_1 6.1131qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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