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BioActivity Data for Compound SMR000076017 (CID 1630687)

BioActivity Outcomes:
Active(3)
 
 
Inactive(856)
 
 
Inconclusive(20)
 
 
Unspecified(3)
 
 
Top Targets:
7tm 4(48)
 
 
alkPPc(16)
 
 
Bcl-2 like(12)
 
 
Tryp SPc(11)
 
 
PTPc(9)
 
 
BioAssay Types:
Screening(589)
 
 
 
 
 
Confirmatory(259)
 
 
 
 
 
Literature(11)
 
 
BioAssay Categories:
In vitro(2)
 
 
In vivo(1)
 
 
Biochemical(123)
 
 
Toxicity(14)
 
 
 
Cell-based(141)
 
 
 
Organism-base..(10)
 
 
BioActivity Types:
Potency(171)
 
 
 
 
IC50(50)
 
 
EC50(12)
 
 
 
AC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 809    Data Row: 882   Total Pages: 45   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID4258011]
EC50_uM 0.4867Fluorescence Polarization Cell-Free Homogeneous Dose Retest to Confirm Inhibitors of the LANA Histone H2A/H2B Interaction [AID435023, Type: confirmatory]LANA [Human herpesvirus 8] [gi:139472804]
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2
[SID4258011]
Fluorescence Polarization Cell-Free Homogeneous Primary HTS to Identify Inhibitors of the LANA Histone H2A/H2B Interaction [AID2629, Type: screening]LANA [Human herpesvirus 8] [gi:139472804]
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3
[SID4258011]
IL-1B Induced NFkB Translocation - Primary Screen [AID796, Type: screening]
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4
[SID4258011]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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5
[SID4258011]
Potency Activators of T cell receptors: qHTS campaign [AID504894, Type: confirmatory]T cell receptor, partial [Homo sapiens] [gi:553160]
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6
[SID4258011]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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7
[SID4258011]
Potency 100HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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8
[SID96099509]
AC50_uM 350Luminescent Cell-Based Counter Screen to Identify Non-Cytotoxic Compounds [AID463211, Type: confirmatory]LANA [Human herpesvirus 8] [gi:139472804]
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9
[SID96099509]
Fluorescence Polarization Cell-Free Homogeneous Counter Screen to Identify Inhibitors of DNA Intercalation [AID463198, Type: other]LANA [Human herpesvirus 8] [gi:139472804]
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10
[SID4258011]
Potency qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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11
[SID4258011]
uHTS identification of small molecule inhibitors of tim10-1 yeast via a luminescent assay [AID463190, Type: screening]TPA: protein transporter TIM10 [Saccharomyces cerevisiae S288c] [gi:285809906]
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12
[SID4258011]
uHTS identification of small molecule inhibitors of tim10 yeast via a luminescent assay [AID463195, Type: screening]TPA: protein transporter TIM10 [Saccharomyces cerevisiae S288c] [gi:285809906]
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13
[SID4258011]
uHTS identification of small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID463212, Type: screening]TPA: protein transporter TIM23 [Saccharomyces cerevisiae S288c] [gi:285814664]
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14
[SID4258011]
Potency qHTS Assay for Activators of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID1722, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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15
[SID4258011]
Potency qHTS Assay for Inhibitors of Leishmania Mexicana Pyruvate Kinase (LmPK) [AID1721, Type: confirmatory]pyruvate kinase [Leishmania mexicana mexicana] [gi:290753097]
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16
[SID4258011]
Screen for inhibitors of the SWI/SNF chromatin remodeling complex (esBAF) in mouse embryonic stem cells with Luciferase reporter assay Measured in Cell-Based System Using Plate Reader - 2141-01_Inhibitor_SinglePoint_HTS_Activity [AID602393, Type: screening]transcription activator BRG1 isoform 1 [Mus musculus] [gi:291463269]
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17
[SID4258011]
Potency qHTS of PTHR Inhibitors: Primary Screen [AID743266, Type: confirmatory]parathyroid hormone/parathyroid hormone-related peptide receptor precursor [Homo sapiens] [gi:296080761]
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18
[SID4258011]
Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of human platelet-activating factor acetylhydrolase 1b, catalytic subunit 2 (PAFAH1B2) [AID492953, Type: screening]platelet-activating factor acetylhydrolase IB subunit beta isoform b [Homo sapiens] [gi:296080766]
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19
[SID4258011]
Aggregation and Clearance of Mutant Huntingtin Protein [AID483, Type: screening]Huntingtin [gi:296434520]
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20
[SID4258011]
IC50 Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents [AID1903, Type: confirmatory]large T antigen [Simian virus 40] [gi:297591903]
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