SureCN4319733 (CID 16222640) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(3)
 
 
Inconclusive(1)
 
 
Unspecified(5)
 
 
Top Targets:
M1 LTA4H(3)
 
 
 
BioAssay Types:
Literature(9)
 
 
 
 
BioActivity Types:
IC50(2)
 
 
Kd(1)
 
 
SAR
Target summary
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 9    Data Row: 9   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103709223]
IC50 0.087Inhibition of human recombinant LTA4H hydrolysis assessed as inhibition of LTB4 formation by LC-MS/MS [AID445449, Type: Literature]Leukotriene A-4 hydrolase [gi:126353]
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2
[SID103709223]
IC50 0.449Inhibition of human LTA4H hydrolysis assessed as inhibition of Ca2+ ionophore-stimulated LTB4 formation in human whole blood by ELISA [AID445450, Type: Literature]Leukotriene A-4 hydrolase [gi:126353]
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3
[SID103709223]
 Cmax in Sprague-Dawley rat at 10 mg/kg, iv [AID445624, Type: Literature]
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4
[SID103709223]
 AUC (0 to infinity) in Sprague-Dawley rat at 10 mg/kg, iv [AID445625, Type: Literature]
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5
[SID103709223]
 Volume of distribution in Sprague-Dawley rat at 10 mg/kg, iv [AID445627, Type: Literature]
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6
[SID103709223]
 Clearance in Sprague-Dawley rat at 10 mg/kg, iv [AID445628, Type: Literature]
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7
[SID103709223]
 Metabolic stability in rat liver microsomes assessed as compound remaining after 30 mins [AID445451, Type: Literature]
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8
[SID103709223]
 Half life in Sprague-Dawley rat at 10 mg/kg, po [AID445623, Type: Literature]
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9
[SID103709223]
Kd Binding affinity to human recombinant LTA4H by isothermal calorimetry [AID445452, Type: Literature]Leukotriene A-4 hydrolase [gi:126353]
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