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BioActivity Data for Compound ivacaftor (CID 16220172)

BioActivity Outcomes:
Active(5)
 
 
Inactive(17)
 
 
Inconclusive(5)
 
 
Top Targets:
ABCC CFTR1(1)
 
 
PTKc Yes(1)
 
 
Pyruvate Kina..(1)
 
 
BioAssay Types:
Confirmatory(24)
 
 
 
 
Literature(1)
 
 
BioAssay Categories:
Toxicity(1)
 
 
BioActivity Types:
Potency(26)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 27    Data Row: 27   Total Pages: 2   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID124950685]
Potency 2.9566Immunotoxin (SS1P) sensitization/mitigation study - treatment arm [AID1159511, Type: confirmatory]
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2
[SID124950685]
Potency 5.2576Immunotoxin (HA22) sensitization/mitigation study - treatment arm [AID1159512, Type: confirmatory]
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3
[SID124950685]
Potency 16.6261Immunotoxin (HA22) sensitization/mitigation study [AID1159510, Type: confirmatory]
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4
[SID124950685]
Potency 23.6905qHTS Assay for Identification of Small Molecule Antagonists for NFkB Signaling Pathway. [AID624479, Type: confirmatory]
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5
[SID136926964]
Cystic fibrosis transmembrane conductance regulator positive modulator [AID742991, Type: other]Cystic fibrosis transmembrane conductance regulator [gi:147744553]
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6
[SID124950685]
Potency 0.0017qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (DD2) proliferation [AID743345, Type: confirmatory]
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7
[SID124950685]
Potency 0.0421qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (HB3) proliferation [AID743347, Type: confirmatory]
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8
[SID124950685]
Potency 0.0749qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (3D7) proliferation [AID743344, Type: confirmatory]
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9
[SID124950685]
Potency 0.9433qHTS profiling of the MIPE4 collection as inhibitors of Plasmodium falciparum (DD2) proliferation (Rep 2) [AID743346, Type: confirmatory]
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10
[SID124950685]
Potency 18.6548Cell Proliferation Assay against a hMSC Cell Line [AID651696, Type: confirmatory]
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11
[SID124950685]
Potency 21.1177qHTS profiling for inhibitors of Plasmodium falciparum (3D7) proliferation [AID743322, Type: confirmatory]
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12
[SID124950685]
Potency qHTS for small molecule inhibitors of Yes1 kinase: Counter Assay [AID686950, Type: other]
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13
[SID124950685]
Potency Immunotoxin (HA22) sensitization/mitigation study - treatment arm (Run 1) [AID1159530, Type: confirmatory]
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14
[SID124950685]
Potency qHTS for small molecule inhibitors of Yes1 kinase: Primary Screen [AID686947, Type: Literature]tyrosine-protein kinase Yes [Homo sapiens] [gi:4885661]
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15
[SID124950685]
Potency qHTS of Trypanosoma Brucei Inhibitors [AID624173, Type: confirmatory]hypothetical protein, conserved [Trypanosoma brucei] [gi:62359610]
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16
[SID124950685]
Potency qHTS Assay for Identifying Gametocytocidal Compounds [AID743244, Type: confirmatory]
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17
[SID124950685]
Potency Cell Proliferation Assay against the TMD8 Cell Line [AID651645, Type: confirmatory]
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18
[SID124950685]
Potency Cell Proliferation Assay Versus the ED40515 IL2 Dependent ATL cell lines [AID1053195, Type: confirmatory]
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19
[SID124950685]
Potency Cell Proliferation Assay Versus the ED40515 IL2 Independent ATL cell lines [AID1053194, Type: confirmatory]
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20
[SID124950685]
Potency Cell Proliferation Assay against the HBL1 Cell Line [AID651646, Type: confirmatory]
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