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SMR000857110 (CID 16218404) - Compound BioActivity Data
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BioActivity Outcomes:
Active(113)
 
 
Inactive(394)
 
 
Inconclusive(26)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
 
7TM GPCR Srsx(15)
 
 
Troponin(8)
 
 
 
Hexokinase 2(6)
 
 
 
ZnMc TACE lik..(6)
 
 
 
BioAssay Types:
Screening(383)
 
 
 
 
Confirmatory(135)
 
 
 
 
 
Literature(9)
 
 
BioActivity Types:
Potency(103)
 
 
 
 
 
IC50(28)
 
 
 
 
EC50(3)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 481    Data Row: 534   Total Pages: 27   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID56320658]
Potency 0.067qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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2
[SID56320658]
Potency 0.1585qHTS Assay for the Inhibitors of L3MBTL1 [AID485360, Type: confirmatory]lethal(3)malignant brain tumor-like protein 1 isoform I [Homo sapiens] [gi:117938328]
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3
[SID56320659]
Potency 0.3162qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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4
[SID56320659]
Potency 0.3548qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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5
[SID56320659]
Potency 0.7079qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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6
[SID56320659]
Potency 0.7079qHTS Assay to Find Inhibitors of Pin1 [AID504891, Type: confirmatory]peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [Homo sapiens] [gi:5453898]
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7
[SID56320658]
Potency 0.7079qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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8
[SID56320658]
Potency 0.7943qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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9
[SID93576637]
IC50 0.8337Counterscreen for inhibitors of LEDGF/p75-dependent integration: TR-FRET-based biochemical high throughput dose response counterscreen assay to identify activators of HIV-1 Integrase multimerization [AID1053171, Type: confirmatory]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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10
[SID93576637]
IC50 0.8337Counterscreen for inhibitors of LEDGF/p75-dependent integration: TR-FRET-based biochemical high throughput dose response counterscreen assay to identify activators of HIV-1 Integrase multimerization [AID1053171, Type: confirmatory]integrase, partial [Human immunodeficiency virus 1] [gi:2853980]
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11
[SID56320659]
Potency 0.8913qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary Screen [AID720542, Type: confirmatory]apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] [gi:23496270]
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12
[SID56320658]
Potency 1qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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13
[SID93576637]
IC50 1.052TR-FRET-based biochemical high throughput dose response assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID1053172, Type: confirmatory]lens epithelium-derived growth factor p75 [Homo sapiens] [gi:6708281]
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14
[SID93576637]
IC50 1.052TR-FRET-based biochemical high throughput dose response assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID1053172, Type: confirmatory]integrase, partial [Human immunodeficiency virus 1] [gi:2853980]
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15
[SID56320659]
Potency 1.2589qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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16
[SID56320658]
Potency 1.2589qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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17
[SID56320659]
IC50_Mean 1.61Dose Response confirmation of inhibitors of hexokinase domain containing I (HKDC1) [AID504729, Type: confirmatory]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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18
[SID56320659]
Potency 1.6834qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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19
[SID56320659]
IC50 2.724Fluorescence-based biochemical high throughput dose response assay for inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504742, Type: confirmatory]troponin C, slow skeletal and cardiac muscles [Homo sapiens] [gi:4507615]
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20
[SID56320659]
IC50 2.724Fluorescence-based biochemical high throughput dose response assay for inhibitors of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) [AID504742, Type: confirmatory]cardiac alpha tropomyosin [Sus scrofa] [gi:1927]
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