N-(2-aminophenyl)-N-(4-methoxyphenyl)amine hydrochloride (CID 16196093) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(33)
 
 
Inactive(543)
 
 
Inconclusive(33)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(16)
 
 
 
alkPPc(10)
 
 
Bcl-2 like(10)
 
 
7TM GPCR Srsx(8)
 
 
Tryp SPc(7)
 
 
BioAssay Types:
Screening(409)
 
 
 
 
Confirmatory(185)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(124)
 
 
 
 
 
IC50(40)
 
 
 
 
EC50(10)
 
 
AC50(2)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 610    Data Row: 610   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24828685]
IC50 1.053High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1626, Type: confirmatory]
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2
[SID24828685]
IC50 1.41A Cell Based Secondary Assay to Explore Compounds that Modulate Non-Replicating, Drug-tolerant Compounds in Replicating H37Rv TB of Mycobacterium tuberculosis [AID492952, Type: confirmatory]
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3
[SID24828685]
IC50 2.38Dose Response confirmation of uHTS hits for a small molecule inhibitors of MT1-MMP activation in a luminescence assay set 1 [AID652252, Type: confirmatory]
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4
[SID24828685]
IC50 2.72Elucidation of physiology of non-replicating, drug-tolerant Mycobacterium tuberculosis [AID488890, Type: confirmatory]
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5
[SID24828685]
IC50 8.32Dose Response confirmation of uHTS hits for a small molecule inhibitors of MT1-MMP activation in a fluorescence assay set 1 [AID652244, Type: confirmatory]MMP14 gene product [Homo sapiens] [gi:4826834]
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6
[SID24828685]
IC50 8.32Dose Response confirmation of uHTS hits for a small molecule inhibitors of MT1-MMP activation in a fluorescence assay set 1 [AID652244, Type: confirmatory]MMP14 gene product [Homo sapiens] [gi:4826834]
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7
[SID24828685]
IC50 8.32Dose Response confirmation of uHTS hits for a small molecule inhibitors of MT1-MMP activation in a fluorescence assay set 1 [AID652244, Type: confirmatory]MMP14 gene product [Homo sapiens] [gi:4826834]
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8
[SID24828685]
Potency 10qHTS Assay for Inhibitors of Human Jumonji Domain Containing 2E (JMJD2E) [AID2147, Type: confirmatory]Chain A, Crystal Structure Of The Human 2-Oxoglutarate Oxygenase Loc390245 [gi:221046486]
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9
[SID24828685]
Potency 10qHTS for Inhibitors of Glutaminase (GLS) [AID624170, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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10
[SID24828685]
Potency 12.5893qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP) [AID1688, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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11
[SID24828685]
Potency 12.5893qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP) [AID1688, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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12
[SID24828685]
Potency 15.8489qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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13
[SID24828685]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID24828685]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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15
[SID24828685]
Potency 20.5962qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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16
[SID24828685]
Potency 22.3872qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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17
[SID24828685]
Potency 35.4813qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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18
[SID24828685]
CC50 38.065A Cell Based Secondary Assay to Explore Cytotoxicity in THP-1 Cells of Compounds that Modulate Non-Replicating, Drug-tolerant Mycobacterium tuberculosis [AID489025, Type: confirmatory]
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19
[SID24828685]
IC50 42.815Discovery of Small Molecule Probes for H1N1 Influenza NS1A [AID504329, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/California/07/2009(H1N1))] [gi:227977143]
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20
[SID24828685]
Potency 44.6684qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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21
[SID24828685]
Potency 44.6684Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) - Round 2 Cherry Picks [AID504841, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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22
[SID24828685]
 Fluorescence polarization-based biochemical high throughput confirmation assay to identify inhibitors of tRNA 2'-phosphotransferase (TPT1). [AID2149, Type: screening]likely tRNA 2'-phosphotransferase [Candida albicans SC5314] [gi:68476498]
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23
[SID24828685]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of tRNA 2'-phosphotransferase (TPT1). [AID1962, Type: screening]likely tRNA 2'-phosphotransferase [Candida albicans SC5314] [gi:68476498]
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24
[SID24828685]
 Fluorescence polarization-based counterscreen assay for inhibitors of tRNA 2'-phosphotransferase (TPT1): biochemical high throughput screening assay to identify inhibitors of RNAse T1. [AID2153, Type: screening]unnamed protein product [Aspergillus oryzae] [gi:83774548]
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25
[SID24828685]
 Fluorescence polarization-based counterscreen assay for inhibitors of tRNA 2'-phosphotransferase (TPT1): biochemical high throughput screening assay to identify inhibitors of RNAse T1. [AID2153, Type: screening]unnamed protein product [Aspergillus oryzae] [gi:83774548]
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26
[SID24828685]
 uHTS identification of small molecule inhibitors of tim10-1 yeast via a luminescent assay [AID463190, Type: screening]TPA: Tim10p [Saccharomyces cerevisiae S288c] [gi:285809906]
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27
[SID24828685]
 uHTS identification of inhibitors of MT1-MMP activation in a fluoresence assay [AID651647, Type: screening]MMP14 gene product [Homo sapiens] [gi:4826834]
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28
[SID24828685]
 uHTS identification of inhibitors of MT1-MMP activation in a fluoresence assay [AID651647, Type: screening]MMP14 gene product [Homo sapiens] [gi:4826834]
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29
[SID24828685]
 uHTS identification of inhibitors of MT1-MMP activation in a fluoresence assay [AID651647, Type: screening]MMP14 gene product [Homo sapiens] [gi:4826834]
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30
[SID24828685]
 Single concentration validation of uHTS hits for a small molecule inhibitors of MT1-MMP activation in a fluoresence assay [AID652235, Type: screening]MMP14 gene product [Homo sapiens] [gi:4826834]
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31
[SID24828685]
 Single concentration validation of uHTS hits for a small molecule inhibitors of MT1-MMP activation in a fluoresence assay [AID652235, Type: screening]MMP14 gene product [Homo sapiens] [gi:4826834]
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32
[SID24828685]
 Single concentration validation of uHTS hits for a small molecule inhibitors of MT1-MMP activation in a fluoresence assay [AID652235, Type: screening]MMP14 gene product [Homo sapiens] [gi:4826834]
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33
[SID24828685]
 uHTS identification of inhibitors of Rpn11 in a Fluorescent Polarization assay [AID588493, Type: screening]PSMD14 protein [Homo sapiens] [gi:16306916]
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34
[SID24828685]
 Inhibition of the MLL-AF4-AF9 Interaction in Pediatric Leukemia Measured in Biochemical System Using Plate Reader - 2160-01_Inhibitor_SinglePoint_HTS_Activity [AID651704, Type: screening]MLLT3 gene product [Homo sapiens] [gi:156104889]
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35
[SID24828685]
 uHTS identification of small molecule inhibitors of the catalytic domain of the SUMO protease, SENP1 in a FRET assay [AID624204, Type: screening]SENP1 gene product [Homo sapiens] [gi:7657550]
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36
[SID24828685]
 HTS-Luminescent assay for inhibitors of ALR by detection of hydrogen peroxide production Measured in Biochemical System Using Plate Reader - 2036-02_Inhibitor_SinglePoint_HTS [AID485317, Type: screening]FAD-linked sulfhydryl oxidase ALR [Homo sapiens] [gi:54112432]
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37
[SID24828685]
 A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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38
[SID24828685]
 HTS to identify compounds that promote myeloid differentiation with MLPCN compound set [AID624256, Type: screening]
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39
[SID99380871]
 Cytotoxicity Assay of T Cells stimulated with concanavalin A. [AID504864, Type: screening]
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40
[SID160693355]
 GSK_TB: Intracellular minimum inhibitory concentration (MIC) BCG assay [AID686910, Type: other]
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41
[SID24828685]
 Leishmania major promastigote HTS [AID1063, Type: screening]
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42
[SID24828685]
 HTS to identify inhibitors of zVAD Induced Cell Death in L929 Cells. [AID1377, Type: screening]
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43
[SID24828685]
 HCS to Identify Inhibitors of Dynein Mediated Cargo Transport on Microtubules. [AID1381, Type: screening]
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44
[SID24828685]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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45
[SID24828685]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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46
[SID24828685]
Potency 6.3096qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]RAB9A gene product [Homo sapiens] [gi:4759012]
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47
[SID24828685]
Potency 25.1189qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1) [AID485290, Type: confirmatory]Chain A, Crystal Structure Of Human Tyrosyl-Dna Phosphodiesterase (Tdp1) [gi:20150581]
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48
[SID24828685]
Potency 100qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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49
[SID24828685]
Potency 100qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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50
[SID24828685]
 HTS for small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress [AID2732, Type: screening]Ddit3 gene product [Mus musculus] [gi:160707929]
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