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MLS000682120 (CID 16195508) - Compound BioActivity Data
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BioActivity Outcomes:
Active(52)
 
 
Inactive(551)
 
 
Inconclusive(32)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
7TM GPCR Srsx(17)
 
 
 
alkPPc(10)
 
 
Bcl-2 like(9)
 
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(405)
 
 
 
 
Confirmatory(206)
 
 
 
 
 
Literature(11)
 
 
 
BioActivity Types:
Potency(150)
 
 
 
 
 
IC50(40)
 
 
 
EC50(12)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 574    Data Row: 636   Total Pages: 32   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24823548]
Potency 1.4125qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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2
[SID24823548]
IC50 3.5342Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors [AID1417, Type: confirmatory]Mcl-1 [Homo sapiens] [gi:7582271]
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3
[SID24823548]
Potency 7.5686qHTS for antagonists of the Thyroid Stimulation Hormone Receptor: Hit Validation in Primary Screen [AID602292, Type: confirmatory]TSHR protein [Homo sapiens] [gi:118341367]
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4
[SID24823548]
Potency 8.4921qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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5
[SID24823548]
IC50 8.88uHTS fluorescence assay for the identification of Human Immunodeficiency Virus Fusion Inhibitors. [AID1986, Type: confirmatory]envelope glycoprotein [Human immunodeficiency virus 1] [gi:45357394]
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6
[SID24823548]
Potency 9.285Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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7
[SID24823548]
IC50 10Dose response confirmation of small molecule inhibitors of the thioesterase domain of fatty acid synthase via a kinetic, fluorescence intensity assay [AID624326, Type: confirmatory]fatty acid synthase [Homo sapiens] [gi:41872631]
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8
[SID24823548]
IC50 10.95Inhibitors of Plasmodium falciparum M1- Family Alanyl Aminopeptidase (M1AAP) [AID1445, Type: confirmatory]m1-family aminopeptidase [Plasmodium falciparum 3D7] [gi:124512980]
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9
[SID24823548]
Potency 11.2202qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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10
[SID24823548]
IC50 12.4Dose response confirmation of uHTS inhibitor hits of the thioesterase domain of fatty acid synthase via a fluorescence intensity assay [AID624327, Type: confirmatory]fatty acid synthase [Homo sapiens] [gi:41872631]
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11
[SID24823548]
Potency 12.5893qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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12
[SID24823548]
Potency 15.8489Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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13
[SID24823548]
Potency 15.8489qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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14
[SID24823548]
Potency 16.3601qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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15
[SID24823548]
Potency 19.9526HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
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16
[SID24823548]
Potency 20.5962Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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17
[SID24823548]
Potency 21.1923qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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18
[SID24823548]
Potency 25.1189Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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19
[SID24823548]
IC50 33.687Anti-Viral Drugs Against Arbovirus Infections, a Confirmatory Screen [AID1250, Type: confirmatory]
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20
[SID24823548]
Potency 35.4813Confirmation qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) - Round 2 Cherry Picks [AID504841, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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