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SMR000312511 (CID 16194533) - Compound BioActivity Data
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BioActivity Outcomes:
Active(11)
 
 
Inactive(300)
 
 
Inconclusive(11)
 
 
Top Targets:
7TM GPCR Srx(10)
 
 
KCNQ channel(10)
 
 
 
G-alpha(6)
 
 
 
7TM GPCR Srsx(6)
 
 
TRP 2(5)
 
 
BioAssay Types:
Screening(212)
 
 
 
 
Confirmatory(104)
 
 
 
 
Literature(2)
 
 
BioActivity Types:
Potency(61)
 
 
 
 
IC50(31)
 
 
EC50(6)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 302    Data Row: 322   Total Pages: 17   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24814942]
Potency 9.5283qHTS profiling assay for firefly luciferase inhibitor/activator using purifed enzyme and Km concentrations of substrates (counterscreen for miR-21 project) [AID588342, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
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2
[SID24814942]
Specificity screen against KCNQ1 for compounds that potentiate KCNQ2 potassium channels [AID2283, Type: screening]potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens] [gi:32479527]
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3
[SID24814942]
Primary cell-based high-throughput screening assay for identification of compounds that potentiate/activate KCNQ1 potassium channels [AID2648, Type: screening]potassium voltage-gated channel subfamily KQT member 1 isoform 1 [Homo sapiens] [gi:32479527]
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4
[SID24814942]
Confirmatory screen for compounds that potentiate KCNQ2 potassium channels [AID2287, Type: screening]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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5
[SID24814942]
KCNQ2 Counter screen for compounds that protect hERG from block by proarrhythmic agents [AID1942, Type: screening]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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6
[SID24814942]
Primary cell-based high-throughput screening assay for identification of compounds that potentiate KCNQ2 potassium channels [AID2239, Type: screening]potassium voltage-gated channel subfamily KQT member 2 [Rattus norvegicus] [gi:18959272]
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7
[SID24814942]
Primary cell-based screen for identification of compounds that inhibit the Choline Transporter (CHT) [AID488975, Type: screening]high affinity choline transporter 1 [Homo sapiens] [gi:11141885]
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8
[SID24814942]
Counter screen for compounds that protect hERG from block by proarrhythmic agents [AID1839, Type: screening]putative potassium channel subunit [Homo sapiens] [gi:487738]
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9
[SID24814942]
uHTS identification of small molecule inhibitors of tim10 yeast via a luminescent assay [AID463195, Type: screening]TPA: protein transporter TIM10 [Saccharomyces cerevisiae S288c] [gi:285809906]
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10
[SID24814942]
uHTS identification of small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID463212, Type: screening]TPA: protein transporter TIM23 [Saccharomyces cerevisiae S288c] [gi:285814664]
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11
[SID24814942]
Single concentration confirmation of small molecule inhibitors of tim23-1 yeast via a luminescent assay [AID463218, Type: screening]TPA: protein transporter TIM23 [Saccharomyces cerevisiae S288c] [gi:285814664]
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12
[SID24814942]
Potency 2.0787Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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13
[SID24814942]
Potency 7.0795qHTS Assay for Identification of Novel General Anesthetics [AID485281, Type: confirmatory]Chain A, Horse Spleen Apoferritin [gi:254220970]
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14
[SID24814942]
Potency 13.1154Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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15
[SID24814942]
Potency qHTS Assay to Find Inhibitors of Chronic Active B-Cell Receptor Signaling [AID493014, Type: confirmatory]
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16
[SID165232404]
Confirmed inhibitors/blockers of inward-rectifying potassium ion channel Kir2.1 [AID743120, Type: other]
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17
[SID24814942]
Potentiators of Human D1 Dopamine Receptor: qHTS [AID504651, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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18
[SID24814942]
Antagonist of Human D 1 Dopamine Receptor: qHTS [AID504652, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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19
[SID24814942]
Allosteric Agonists of the Human D1 Dopamine Receptor: qHTS [AID504660, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
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20
[SID24814942]
EC50 uHTS identification of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1777, Type: confirmatory]kappa-type opioid receptor isoform 1 [Homo sapiens] [gi:39725940]
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