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BioActivity Data for Compound MLS000871648 (CID 16194431)

BioActivity Outcomes:
Active(18)
 
 
Inactive(673)
 
 
Inconclusive(20)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(41)
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
NR LBD PPAR(9)
 
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(481)
 
 
 
 
Confirmatory(201)
 
 
 
 
 
Literature(11)
 
 
BioAssay Categories:
In vivo(1)
 
 
Biochemical(127)
 
 
 
Toxicity(5)
 
 
Cell-based(134)
 
 
 
 
Organism-base..(11)
 
 
BioActivity Types:
Potency(144)
 
 
 
 
 
IC50(43)
 
 
 
EC50(7)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 642    Data Row: 712   Total Pages: 36   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24814639]
Potency 1.7783qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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2
[SID24814639]
Potency 11.2202qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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3
[SID24814639]
Potency 22.3872qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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4
[SID24814639]
Potency 31.6228qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta isoform 1 [Homo sapiens] [gi:5729982]
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5
[SID24814639]
Average IC50 94.89High Throughput Screen to Identify Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G:#A time-resolved fluorescence resonance energy transfer (TR-FRET) assay for HIV-1 Vif-APOBEC3G interaction [AID1117319, Type: confirmatory]Vif [Human immunodeficiency virus 1] [gi:9629361]
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6
[SID24814639]
Average IC50 94.89High Throughput Screen to Identify Inhibitors Targeting HIV-1 Vif-dependent Degradation of Human APOBEC3G:#A time-resolved fluorescence resonance energy transfer (TR-FRET) assay for HIV-1 Vif-APOBEC3G interaction [AID1117319, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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7
[SID24814639]
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Primary Screen [AID1456, Type: other]electroneutral potassium-chloride cotransporter KCC2 [Homo sapiens] [gi:12003227]
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8
[SID24814639]
uHTS Identification of Diaphorase Inhibitors and Chemcical Oxidizers: Counter Screen for Diaphorase-based Primary Assays [AID1217, Type: screening]Dihydrolipoamide dehydrogenase [Homo sapiens] [gi:17391426]
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9
[SID24814639]
Chemical Genetic Screen to Identify Inhibitors of Mitochondrial Fusion - Primary Screen [AID1362, Type: screening]
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10
[SID24814639]
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Counterscreen with HEK cells [AID1716, Type: other]
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11
[SID24814639]
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Retesting of KCC2 cells with Ouabain [AID1717, Type: other]
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12
[SID24814639]
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Counterscreen 2 with HEK cells [AID1718, Type: other]
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13
[SID24814639]
Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 3 (SRC-3) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID731, Type: screening]peroxisome proliferator-activated receptor gamma isoform 2 [Homo sapiens] [gi:20336229]
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14
[SID24814639]
Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 3 (SRC-3) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID731, Type: screening]nuclear receptor coactivator 3 isoform a [Homo sapiens] [gi:32307126]
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15
[SID24814639]
uHTS identification of small molecule inhibitors of tim10-1 yeast via a luminescent assay [AID463190, Type: screening]TPA: protein transporter TIM10 [Saccharomyces cerevisiae S288c] [gi:285809906]
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16
[SID24814639]
Single concentration confirmation of small molecule inhibitors of tim10-1 yeast via a luminescent assay [AID463213, Type: screening]TPA: protein transporter TIM10 [Saccharomyces cerevisiae S288c] [gi:285809906]
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17
[SID24814639]
Primary cell-based high-throughput screening for identification of compounds that allosterically activate MrgX1 receptor signaling [AID588675, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
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18
[SID24814639]
Identification of Novel Modulators of Cl- dependent Transport Process via HTS: Secondary Assay 3 with KCC2 cells [AID1714, Type: other]electroneutral potassium-chloride cotransporter KCC2 [Homo sapiens] [gi:12003227]
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19
[SID24814639]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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20
[SID24814639]
Factor XIa 1536 HTS [AID798, Type: screening]coagulation factor XI [Homo sapiens] [gi:180352]
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