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MLS000660595 (CID 16194171) - Compound BioActivity Data
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BioActivity Outcomes:
Active(56)
 
 
Inactive(663)
 
 
Inconclusive(18)
 
 
Unspecified(1)
 
 
Top Targets:
7tm 4(43)
 
 
 
Bcl-2 like(11)
 
 
 
alkPPc(10)
 
 
Tryp SPc(10)
 
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(491)
 
 
 
 
Confirmatory(219)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(154)
 
 
 
 
 
IC50(51)
 
 
 
EC50(8)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 669    Data Row: 738   Total Pages: 37   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24813852]
IC50 2.957Dose Response confirmation of uHTS hits for Scp-1 phosphatase using a colorimetric assay [AID540297, Type: confirmatory]carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 isoform 1 [Homo sapiens] [gi:10864009]
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2
[SID24813852]
Potency 3.8273qHTS for Inhibitors of WRN Helicase: BLM Helicase Counterscreen for WRN Inhibitors [AID720503, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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3
[SID24813852]
Potency 6.3096qHTS Assay for Inhibitors of DNA Polymerase Beta [AID485314, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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4
[SID24813852]
Potency 6.3096Inhibitors of DNA Polymerase Beta: Hit validation [AID540280, Type: confirmatory]DNA polymerase beta [Homo sapiens] [gi:4505931]
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5
[SID24813852]
IC50 7.6Dose response confirmation of DNMT1 inhibitors in a Fluorescent Molecular Beacon assay [AID602386, Type: confirmatory]DNA (cytosine-5)-methyltransferase 1 isoform b [Homo sapiens] [gi:4503351]
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6
[SID24813852]
Potency 9.285Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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7
[SID24813852]
IC50_Mean 9.31Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay [AID504719, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3G [Homo sapiens] [gi:13399304]
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8
[SID24813852]
Potency 12.5893qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]menin isoform 1 [Homo sapiens] [gi:18860839]
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9
[SID24813852]
Potency 12.5893qHTS Assay for Inhibitors Targeting the Menin-MLL Interaction in MLL Related Leukemias: Competition With Texas Red Labeled MLL-derived Mutant Peptide [AID1768, Type: confirmatory]histone-lysine N-methyltransferase 2A isoform 2 precursor [Homo sapiens] [gi:56550039]
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10
[SID24813852]
Potency 12.5893qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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11
[SID24813852]
Potency 17.7828qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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12
[SID24813852]
Potency 19.1821qHTS for Inhibitors of WRN Helicase: Confirmatory Assay for Cherry-picked Compounds. [AID720497, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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13
[SID24813852]
IC50 19.5Dose response confirmation of uHTS RPN11 inhibitor hits in a Fluorescence Polarization assay [AID602368, Type: confirmatory]PSMD14 protein [Homo sapiens] [gi:16306916]
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14
[SID24813852]
Potency 20.4339qHTS Assay for Inhibitors of GCN5L2: Hit confirmation [AID588347, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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15
[SID24813852]
Potency 25.1189qHTS Assay for Inhibitors of RecQ-Like Dna Helicase 1 (RECQ1) [AID2549, Type: confirmatory]Chain A, Structure Of Human Recq-Like Helicase In Complex With A Dna Substrate [gi:282403581]
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16
[SID24813852]
Potency 29.9349qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds [AID720496, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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17
[SID24813852]
Potency 39.8107qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta isoform 1 [Homo sapiens] [gi:5729982]
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18
[SID24813852]
Potency 44.6684qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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19
[SID24813852]
IC50_Mean 49.3Dose Response confirmation of APOBEC3G DNA Deaminase Inhibitors via a A3A counterscreen [AID504722, Type: confirmatory]DNA dC->dU-editing enzyme APOBEC-3A isoform a [Homo sapiens] [gi:21955158]
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20
[SID24813852]
IC50 50.5Dose Response validation of uHTS RPN11 inhibitor hits using a Thrombin Fluorescence Polarization assay [AID602369, Type: confirmatory]TPA: prothrombin [Bos taurus] [gi:296479639]
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