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SMR000284753 (CID 16192912) - Compound BioActivity Data
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BioActivity Outcomes:
Active(75)
 
 
Inactive(451)
 
 
Inconclusive(50)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(20)
 
 
7TM GPCR Srsx(17)
 
 
Tryp SPc(8)
 
 
 
Bcl-2 like(8)
 
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(354)
 
 
 
 
Confirmatory(201)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(143)
 
 
 
 
 
IC50(34)
 
 
 
 
EC50(19)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 524    Data Row: 577   Total Pages: 12   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24808475]
Potency 0.2152qHTS for Inhibitors of WRN Helicase: Thiazole Orange DNA Binding Counterscreen [AID720499, Type: confirmatory]
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2
[SID24808475]
Potency 0.3411qHTS for Inhibitors of WRN Helicase: Confirmatory Assay for Cherry-picked Compounds. [AID720497, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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3
[SID24808475]
Potency 0.4109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID24808475]
Potency 0.5805qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID24808475]
Potency 0.6806qHTS for Inhibitors of WRN Helicase: BLM Helicase Counterscreen for WRN Inhibitors [AID720503, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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6
[SID24808475]
Potency 1.5849qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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7
[SID24808475]
Absolute IC50 (XBP1) 2.28XBP1 DR counterscreen for CHOP [AID504313, Type: confirmatory]XBP1 [Homo sapiens] [gi:47678753]
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8
[SID24808475]
IC50_MICROM 3.12Dose Response Assay for Inhibitors of the beta-Arrestin-Adaptor Protein 2 Interaction for Cherry Pick 1 [AID588783, Type: confirmatory]Arrestin, beta 1 [Homo sapiens] [gi:13177715]
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9
[SID24808475]
Potency 3.1623VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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10
[SID24808475]
Potency 3.1623Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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11
[SID24808475]
Potency 10Quantitative High-Throughput Screen for Regulators of Epigenetic Control [AID1865, Type: confirmatory]
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12
[SID24808475]
Potency 10qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]plasminogen precursor [Mus musculus] [gi:257471003]
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13
[SID24808475]
Potency 10qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator precursor [Mus musculus] [gi:6679377]
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14
[SID24808475]
Potency 10qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase plasminogen activator surface receptor precursor [Mus musculus] [gi:7242179]
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15
[SID24808475]
Potency 14.1254qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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16
[SID24808475]
Potency 15.8489qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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17
[SID24808475]
Potency 16.3601qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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18
[SID24808475]
Potency 17.7828qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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19
[SID24808475]
Potency 18.3564Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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20
[SID24808475]
EC50_MICROM 20.99Profiling Assay to determine GST-GSH interactions in multiplex bead-based assays [AID1769, Type: confirmatory]glutathione S-transferase [Homo sapiens] [gi:31933]
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21
[SID24808475]
Potency 44.6684qHTS Assay for Inhibitors of BAZ2B [AID504333, Type: confirmatory]bromodomain adjacent to zinc finger domain 2B [Homo sapiens] [gi:6683500]
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22
[SID24808475]
Potency 89.1251qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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23
[SID24808475]
In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_SinglePoint_HTS_Activity [AID504582, Type: screening]HSP40, subfamily A, putative [Plasmodium falciparum 3D7] [gi:124809271]
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24
[SID24808475]
Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID1032, Type: screening]NCOA2 protein [Homo sapiens] [gi:62201602]
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25
[SID24808475]
Measurement of TR-FRET detection format artefact in the screen for agonists of steroid receptor coactivator 2 (SRC-2) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID1049, Type: other]NCOA2 protein [Homo sapiens] [gi:62201602]
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26
[SID24808475]
Primary cell-based high throughput assay for inhibitors of the Janus kinase 2 mutant JAK2V617F [AID1446, Type: screening]Janus kinase 2 (a protein tyrosine kinase) [Homo sapiens] [gi:119579178]
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27
[SID24808475]
Single concentration validation of Csn-Mediated Deneddylation of Cullin-Ring Ligase Using a Thrombin Fluorescence Polarization Assay [AID720656, Type: other]TPA: prothrombin [Bos taurus] [gi:296479639]
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28
[SID87349492]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of COUP-TFII (NR2F2) [AID686940, Type: screening]COUP transcription factor 2 isoform a [Homo sapiens] [gi:14149746]
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29
[SID24808475]
uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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30
[SID24808475]
uHTS identification of small molecule inhibitors of Csn-mediated Deneddylation of Cullin-Ring Ligases, vis a fluorescence polarization assay [AID651999, Type: screening]COP9 signalosome complex subunit 5 [Homo sapiens] [gi:38027923]
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31
[SID24808475]
Primary biochemical High Throughput Screening assay for agonists of the steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID631, Type: screening]nuclear receptor coactivator 1 isoform 1 [Homo sapiens] [gi:22538455]
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32
[SID24808475]
Measurement of TR-FRET detection format artefact in the screen for agonists of steroid receptor coactivator 1 (SRC-1) recruitment by the peroxisome proliferator-activated receptor gamma (PPARgamma) [AID1051, Type: other]nuclear receptor coactivator 1 isoform 1 [Homo sapiens] [gi:22538455]
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33
[SID24808475]
HTS Assay for Peg3 Promoter Inhibitors [AID588405, Type: screening]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
View
34
[SID24808475]
HTS for small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress [AID2732, Type: screening]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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35
[SID24808475]
CHOP Confirmatory Screen [AID504437, Type: screening]DNA damage-inducible transcript 3 protein [Mus musculus] [gi:160707929]
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36
[SID24808475]
Leishmania major promastigote HTS [AID1063, Type: screening]
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37
[SID24808475]
Chemical Genetic Screen to Identify Inhibitors of Mitochondrial Fusion - Primary Screen [AID1362, Type: screening]
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38
[SID24808475]
Counterscreen for inhibitors of Janus kinase 2 mutant JAK2V617F: Cell-based high throughput assay to identify inhibitors of parental Ba/F3 cell viability. [AID1486, Type: screening]
View
39
[SID87349492]
HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_SinglePoint_HTS_Activity [AID651610, Type: screening]
View
40
[SID87349492]
Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_SinglePoint_HTS_Activity [AID651661, Type: screening]
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41
[SID24808475]
Flow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with MLPCN Compound Library [AID651702, Type: screening]
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42
[SID24808475]
Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588674, Type: screening]
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43
[SID24808475]
HTS to Find Inhibitors of Pathogenic Pemphigus Antibodies [AID588358, Type: screening]
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44
[SID24808475]
High-content cell-based screening for modulators of autophagy [AID463193, Type: screening]microtubule-associated proteins 1A/1B light chain 3A isoform b [Homo sapiens] [gi:31563518]
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45
[SID24808475]
Primary screen for compounds that activate Insulin promoter activity in TRM-6 cells [AID1296, Type: screening]proinsulin [Homo sapiens] [gi:59036749]
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46
[SID24808475]
Epi-absorbance primary biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase [AID1556, Type: screening]metallo-beta-lactamase IMP-1 [Pseudomonas aeruginosa] [gi:27368096]
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47
[SID24808475]
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bfl-1 [AID1008, Type: screening]bcl-2-related protein A1 isoform 1 [Homo sapiens] [gi:4757840]
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48
[SID24808475]
Inhibitors of the EP2 Prostaglandin E2 Receptor - Primary Screen [AID1422, Type: screening]prostaglandin E2 receptor EP2 subtype [Homo sapiens] [gi:31881630]
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49
[SID24808475]
uHTS of Mcl-1/Noxa interaction inhibitors [AID1022, Type: screening]Mcl-1 [Homo sapiens] [gi:7582271]
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50
[SID24808475]
uHTS identification of small molecule inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase, LMPTP, via a fluorescence intensity assay [AID651560, Type: screening]Low molecular weight phosphotyrosine protein phosphatase [gi:1709543]
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