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SMR000284753 (CID 16192912) - Compound BioActivity Data
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BioActivity Outcomes:
Active(75)
 
 
Inactive(458)
 
 
Inconclusive(50)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(20)
 
 
7TM GPCR Srsx(17)
 
 
Bcl-2 like(8)
 
 
 
Tryp SPc(8)
 
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(355)
 
 
 
 
Confirmatory(201)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(143)
 
 
 
 
 
IC50(34)
 
 
 
 
EC50(19)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 525    Data Row: 584   Total Pages: 30   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24808475]
Potency 0.2152qHTS for Inhibitors of WRN Helicase: Thiazole Orange DNA Binding Counterscreen [AID720499, Type: confirmatory]
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2
[SID24808475]
Potency 0.3411qHTS for Inhibitors of WRN Helicase: Confirmatory Assay for Cherry-picked Compounds. [AID720497, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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3
[SID24808475]
Potency 0.4109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID24808475]
Potency 0.5805qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID24808475]
Potency 0.6806qHTS for Inhibitors of WRN Helicase: BLM Helicase Counterscreen for WRN Inhibitors [AID720503, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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6
[SID24808475]
Potency 1.5849qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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7
[SID24808475]
Absolute IC50 (XBP1) 2.28XBP1 DR counterscreen for CHOP [AID504313, Type: confirmatory]XBP1 [Homo sapiens] [gi:47678753]
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8
[SID24808475]
IC50_MICROM 3.12Dose Response Assay for Inhibitors of the beta-Arrestin-Adaptor Protein 2 Interaction for Cherry Pick 1 [AID588783, Type: confirmatory]Arrestin, beta 1 [Homo sapiens] [gi:13177715]
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9
[SID24808475]
Potency 3.1623VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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10
[SID24808475]
Potency 3.1623Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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11
[SID24808475]
Potency 10Quantitative High-Throughput Screen for Regulators of Epigenetic Control [AID1865, Type: confirmatory]
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12
[SID24808475]
Potency 10qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]plasminogen precursor [Mus musculus] [gi:257471003]
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13
[SID24808475]
Potency 10qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator precursor [Mus musculus] [gi:6679377]
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14
[SID24808475]
Potency 10qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase plasminogen activator surface receptor precursor [Mus musculus] [gi:7242179]
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15
[SID24808475]
Potency 14.1254qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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16
[SID24808475]
Potency 15.8489qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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17
[SID24808475]
Potency 16.3601qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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18
[SID24808475]
Potency 17.7828qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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19
[SID24808475]
Potency 18.3564Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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20
[SID24808475]
EC50_MICROM 20.99Profiling Assay to determine GST-GSH interactions in multiplex bead-based assays [AID1769, Type: confirmatory]glutathione S-transferase, partial [Homo sapiens] [gi:31933]
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