MLS000856673 (CID 16192893) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(39)
 
 
Inactive(549)
 
 
Inconclusive(27)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(16)
 
 
alkPPc(10)
 
 
Bcl-2 like(10)
 
 
TRP 2(10)
 
 
 
KCNQ channel(9)
 
 
 
BioAssay Types:
Screening(421)
 
 
 
 
Confirmatory(179)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(121)
 
 
 
 
 
IC50(37)
 
 
 
EC50(13)
 
 
 
AC50(3)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 616    Data Row: 616   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24808232]
EC50 0.1Luminescence Cell-Based/Microorganism Dose Confirmation HTS to Identify Inhibitors of T.Cruzi Replication. [AID2044, Type: confirmatory]
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2
[SID24808232]
EC50 0.131Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Infection [AID2294, Type: confirmatory]
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3
[SID24808232]
Potency 3.2643qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID24808232]
Potency 3.2643qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID24808232]
Potency 3.2643qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID24808232]
Potency 3.6626qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID24808232]
Potency 3.6626qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID24808232]
Potency 3.6626qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID24808232]
EC50 3.83A cytotoxicity screen of small molecule inhibitors of the PhoP regulon in Salmonella typhi identified in the primary screen [AID2252, Type: confirmatory]
View
10
[SID24808232]
AC50 4.84Shn3: Dual-Go Shn3RL cells Measured in Cell-Based System Using Plate Reader - 2134-02_Inhibitor_Dose_CherryPick_Activity [AID624133, Type: confirmatory]
View
11
[SID24808232]
IC50 5A small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID1850, Type: confirmatory]
View
12
[SID24808232]
Potency 7.0795qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
View
13
[SID24808232]
AC50 7.09Shn3: Cytotox assay Measured in Cell-Based System Using Plate Reader - 2134-03_Inhibitor_Dose_CherryPick_Activity [AID624134, Type: confirmatory]
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14
[SID24808232]
Potency 8.9125qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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15
[SID24808232]
Potency 8.9125qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode) [AID624417, Type: confirmatory]glp-1 receptor [Homo sapiens] [gi:1724069]
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16
[SID24808232]
IC50 16.789A screen for inhibitors of the PhoP regulon in Salmonella Typhi using a modified counterscreen [AID1985, Type: confirmatory]
View
17
[SID24808232]
Potency 18.3564qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
View
18
[SID24808232]
Potency 18.3564Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
View
19
[SID24808232]
Potency 18.3564Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
View
20
[SID24808232]
Potency 18.3564Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
View
21
[SID24808232]
Potency 18.3564Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
View
22
[SID24808232]
AC50 21.73Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_Dose_CherryPick_Activity [AID624132, Type: confirmatory]
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23
[SID24808232]
Potency 23.1093qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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24
[SID24808232]
Potency 23.1093qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
View
25
[SID24808232]
Potency 23.1093qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
View
26
[SID24808232]
IC50 25.99A counter screen for small molecule screen for inhibitors of the PhoP regulon in Salmonella typhi [AID2384, Type: confirmatory]
View
27
[SID24808232]
 Counter screen for compounds that inhibit transient receptor potential cation channel C6 (TRPC6) [AID2780, Type: screening]
View
28
[SID24808232]
 Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Replication [AID1885, Type: screening]
View
29
[SID24808232]
 Leishmania major promastigote HTS [AID1063, Type: screening]
View
30
[SID24808232]
 Primary cell-based screen for identification of compounds that inhibit the two-pore domain potassium channel KCNK3 [AID602410, Type: screening]Kcnk3 channel [Homo sapiens] [gi:11093520]
View
31
[SID24808232]
 Specificity screen against KCNQ1/KCNE1 for identification of compounds that inhibit KCNQ1 potassium channels [AID652147, Type: screening]KCNQ1 gene product [Homo sapiens] [gi:32479527]
View
32
[SID24808232]
 Primary cell-based high-throughput screening assay for identification of compounds that inhibit KCNQ1 potassium channels [AID2642, Type: screening]KCNQ1 gene product [Homo sapiens] [gi:32479527]
View
33
[SID24808232]
 Validation (re-confirmation) assay for identification of compounds that inhibit KCNQ1 potassium channels [AID588353, Type: screening]KCNQ1 gene product [Homo sapiens] [gi:32479527]
View
34
[SID24808232]
 Validation for compounds that inhibit KCNQ1 potassium channels on automated electrophysiology assay [AID624120, Type: other]KCNQ1 gene product [Homo sapiens] [gi:32479527]
View
35
[SID24808232]
 Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) [AID624467, Type: screening]TAAR1 gene product [Homo sapiens] [gi:21264324]
View
36
[SID24808232]
 Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) [AID624467, Type: screening]TAAR1 gene product [Homo sapiens] [gi:21264324]
View
37
[SID24808232]
 Re-confirmation screening for identification of compounds that antagonize MrgX1 receptor signaling [AID602420, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
View
38
[SID24808232]
 Re-confirmation screening for identification of compounds that antagonize MrgX1 receptor signaling [AID602420, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
View
39
[SID24808232]
 Primary cell-based high-throughput screening for identification of compounds that antagonize MrgX1 receptor signaling [AID588676, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
View
40
[SID24808232]
 Primary cell-based high-throughput screening for identification of compounds that antagonize MrgX1 receptor signaling [AID588676, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
View
41
[SID24808232]
 Confirmatory screen for identification of compounds that inhibit transient receptor potential cation channel C6 (TRPC6) [AID488960, Type: screening]short transient receptor potential channel 6 [Mus musculus] [gi:160333370]
View
42
[SID24808232]
 Primary cell-based high-throughput screening for identification of compounds that inhibit/block calcium-activated chloride channels (TMEM16A) [AID588511, Type: screening]Ano1 gene product [Mus musculus] [gi:334278898]
View
43
[SID24808232]
 Specificity screen against KCNQ2 for identification of compounds that inhibit KCNQ1 potassium channels [AID651746, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
View
44
[SID24808232]
 Specificity screen against KCNQ2 for identification of compounds that inhibit KCNQ1 potassium channels [AID651746, Type: screening]Kcnq2 gene product [Rattus norvegicus] [gi:18959272]
View
45
[SID24808232]
 Single concentration confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay [AID602428, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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46
[SID24808232]
 Single concentration confirmation of uHTS antagonist hits from Gli-SUFU in a luminescent reporter assay [AID602428, Type: screening]Gli1 [Mus musculus] [gi:6009644]
View
47
[SID24808232]
 uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
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48
[SID24808232]
 uHTS identification of Gli-Sufu Antagonists in a luminescence reporter assay [AID588413, Type: screening]Gli1 [Mus musculus] [gi:6009644]
View
49
[SID24808232]
 Single concentration validation of uHTS antagonist hits from Gli-SUFU in a luminescent cytotoxicity assay [AID651994, Type: screening]Gli1 [Mus musculus] [gi:6009644]
View
50
[SID24808232]
 Single concentration validation of uHTS antagonist hits from Gli-SUFU in a luminescent cytotoxicity assay [AID651994, Type: screening]Gli1 [Mus musculus] [gi:6009644]
View