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SMR000286543 (CID 16192857) - Compound BioActivity Data
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BioActivity Outcomes:
Active(149)
 
 
Inactive(486)
 
 
Inconclusive(54)
 
 
Unspecified(2)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
7TM GPCR Srsx(16)
 
 
G-alpha(8)
 
 
 
Bcl-2 like(8)
 
 
KCNQ channel(8)
 
 
 
BioAssay Types:
Screening(426)
 
 
 
 
Confirmatory(231)
 
 
 
 
 
Literature(15)
 
 
 
 
BioActivity Types:
Potency(147)
 
 
 
 
 
IC50(39)
 
 
 
 
EC50(32)
 
 
 
 
AC50(8)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 626    Data Row: 691   Total Pages: 35   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24807744]
CC50 1.87e-06Cytotoxicity counterscreen assay for transcriptional activators of heat shock protein 70 (Hsp70) [AID1259, Type: confirmatory]
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2
[SID24807744]
EC50 0.004Luminescence Cell-Based/Microorganism Primary HTS to Identify Inhibitors of T.Cruzi Infection [AID2294, Type: confirmatory]
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3
[SID24807744]
EC50 0.054Fluorescence Cell-Based Retest of C. albicans Growth in the Presence of Fluconazole [AID2467, Type: confirmatory]
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4
[SID103710213]
EC50 0.0654NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay [AID449703, Type: Literature]
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5
[SID24807744]
EC50 0.1Luminescence Cell-Based/Microorganism Dose Confirmation HTS to Identify Inhibitors of T.Cruzi Replication. [AID2044, Type: confirmatory]
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6
[SID24807744]
EC50 0.1Luminescence Cell-Based Dose Confimation HTS to Identify Inhibitors of of 5'UTR Stem-Loop Driven Alpha-Synuclein mRNA Translation in H4 Neuroglioblastoma Cells [AID1988, Type: confirmatory]
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7
[SID24807744]
EC50 0.12Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Resistant C. albicans Growth in the Presence of Fluconazole [AID2423, Type: confirmatory]heat shock protein 90 [Candida albicans] [gi:994798]
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8
[SID24807744]
EC50 0.142Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of Luciferase Translation or Activity in H4 Neuroglioblastoma Cells [AID1990, Type: confirmatory]
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9
[SID103710213]
EC50 0.2276NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay [AID449704, Type: Literature]
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10
[SID24807744]
Absolute IC50 (XBP1) 0.24XBP1 DR counterscreen for CHOP [AID504313, Type: confirmatory]XBP1 [Homo sapiens] [gi:47678753]
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11
[SID24807744]
Potency 0.5174qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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12
[SID24807744]
Potency 0.5174qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID24807744]
IC50_Mean 0.765Concentration-Response Confirmation Assays for HCS to Identify Inhibitors of Dynein Mediated Cargo Transport on Microtubules [AID463136, Type: confirmatory]
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14
[SID24807744]
Potency 1qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP) [AID1688, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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15
[SID24807744]
IC50 1.012High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1626, Type: confirmatory]
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16
[SID24807744]
AC50_uM 1.05HIV-1 Cell Fusion assay for clade B Env AD8 Measured in Cell-Based System Using Plate Reader - 7013-04_Inhibitor_Dose_CherryPick_Activity [AID652062, Type: confirmatory]
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17
[SID24807744]
Potency 1.122qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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18
[SID24807744]
AC50_uM 1.25Anti-Fungal Single Agent: CaCi2 Measured in Microorganism System Using Plate Reader - 2148-01_Inhibitor_Dose_CherryPick_Activity [AID588529, Type: confirmatory]
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19
[SID24807744]
EC50 1.859Luminescence Cell-Based Dose Response HTS Screen to Identify Cytotoxic Compounds of NIH3T3 cells. [AID2010, Type: confirmatory]
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20
[SID24807744]
AC50_uM 1.86HIV entry: Env-mediated Cell Fusion Measured in Cell-Based System Using Plate Reader - 7013-01_Inhibitor_Dose_CherryPick_Activity [AID652057, Type: confirmatory]
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