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MLS000733288 (CID 16191365) - Compound BioActivity Data
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BioActivity Outcomes:
Active(9)
 
 
Inactive(669)
 
 
Inconclusive(11)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
7TM GPCR Srsx(17)
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(470)
 
 
 
 
Confirmatory(201)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(145)
 
 
 
 
IC50(39)
 
 
 
EC50(9)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 631    Data Row: 690   Total Pages: 14   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24799695]
AbsAC40_uM 14.83Sustained Induction of HSF-1 Measured in Cell-Based System Using Plate Reader - 2038-07_Activator_Dose_CherryPick_Activity [AID602296, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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2
[SID24799695]
IC50 33.07Inhibitors of Plasmodium falciparum M1- Family Alanyl Aminopeptidase (M1AAP) [AID1445, Type: confirmatory]m1-family aminopeptidase [Plasmodium falciparum 3D7] [gi:124512980]
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3
[SID24799695]
EC50_uM 38.94Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) [AID435004, Type: confirmatory]Hsf1 protein [Mus musculus] [gi:62740231]
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4
[SID24799695]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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5
[SID24799695]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 B subunit [Escherichia coli O157:H7] [gi:32400300]
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6
[SID24799695]
Assay for Inhibitors of the beta-Arrestin-Adaptor Protein 2 Interaction That Mediate GPCR Degradation and Recycling [AID504490, Type: screening]Arrestin, beta 1 [Homo sapiens] [gi:13177715]
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7
[SID24799695]
Heat Shock Factor-1 (HSF-1) Measured in Cell-Based System Using Plate Reader - 2038-01_Activator_SinglePoint_HTS_Activity [AID504408, Type: screening]
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8
[SID24799695]
Cycloheximide Counterscreen for Small Molecule Inhibitors of Shiga Toxin [AID2314, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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9
[SID24799695]
A qHTS for Small Molecule Inhibitors of Shiga Toxin [AID2315, Type: screening]shiga toxin 1 variant A subunit [Escherichia coli O157:H7] [gi:32400299]
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10
[SID24799695]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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11
[SID24799695]
Potency 5.6234qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS [AID624287, Type: confirmatory]Guanine nucleotide-binding protein G(s) subunit alpha isoforms short [gi:52000961]
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12
[SID24799695]
Potency 28.1838qHTS Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID485341, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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13
[SID24799695]
Potency 89.1251qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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14
[SID24799695]
uHTS Fluorescent assay for identification of inhibitors of Apaf-1 [AID489030, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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15
[SID24799695]
uHTS Fluorescent assay for identification of activators of Apaf-1 [AID489031, Type: screening]Apoptotic peptidase activating factor 1 [Homo sapiens] [gi:187952397]
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16
[SID24799695]
Potency VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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17
[SID24799695]
Potency Nrf2 qHTS screen for inhibitors: counterscreen for cytotoxicity [AID504648, Type: confirmatory]
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18
[SID24799695]
Small Molecules that selectively kill Giardia lamblia: qHTS [AID540267, Type: screening]
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19
[SID24799695]
Fluorescence-based biochemical high throughput primary assay to identify inhibitors of phospholipase C isozymes (PLC-beta3). [AID720704, Type: screening]Phospholipase C, beta 3 (phosphatidylinositol-specific) [Homo sapiens] [gi:148745659]
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20
[SID24799695]
Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of TLR9-MyD88 binding. [AID504734, Type: screening]toll-like receptor 9 [Homo sapiens] [gi:194068499]
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21
[SID24799695]
Potency qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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22
[SID24799695]
Potency qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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23
[SID24799695]
Primary HTS Assay for S1P3 Antagonists [AID485, Type: screening]sphingosine 1-phosphate receptor 3 [Homo sapiens] [gi:38788193]
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24
[SID24799695]
Multiplexed high-throughput screen for small molecule regulators of Bcl-2 family protein interactions, specifically Bim-Bcl-B. [AID951, Type: screening]Bcl-2-like protein 10 [gi:23396469]
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25
[SID24799695]
HTS Assay for Peg3 Promoter Inhibitors [AID588405, Type: screening]protein phosphatase 1 regulatory subunit 15A [Rattus norvegicus] [gi:78486550]
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26
[SID24799695]
Potency qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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27
[SID24799695]
Potency qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1468, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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28
[SID24799695]
IC50 Fluorescence for the identification of compounds that decrease p/CIP protein stability [AID1984, Type: confirmatory]nuclear receptor coactivator 3 [Mus musculus] [gi:118026946]
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29
[SID24799695]
Potency qHTS Inhibitors of AmpC Beta-Lactamase (assay with detergent) [AID485294, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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30
[SID24799695]
High Throughput Screen to Identify Compounds that increase expression of NF-kB in Human Neuronal Cells - Primary Screen [AID1239, Type: screening]transcription factor p65 isoform 1 [Homo sapiens] [gi:223468676]
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31
[SID24799695]
Thrombin 1536 HTS [AID1046, Type: screening]prothrombin [Homo sapiens] [gi:339641]
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32
[SID24799695]
Screen for Chemicals that Inhibit the RAM Network [AID868, Type: screening]
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33
[SID24799695]
NIH Compound Library Profiling: Compound and DTT Dependent Redox Cycling H2O2 Generation. [AID878, Type: screening]
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34
[SID24799695]
Counter Screen for Luciferase-based Primary Inhibition Assays [AID1006, Type: screening]
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35
[SID24799695]
Counter Screen for Luciferase-based Primary Stimulation Assays [AID1027, Type: screening]
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36
[SID24799695]
Leishmania major promastigote HTS [AID1063, Type: screening]
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37
[SID24799695]
EC50 High Throughput Screen for Inhibitors of ER Stress-induced Cell Death in a 384 well format. [AID1222, Type: confirmatory]
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38
[SID24799695]
Anti-Viral Drugs Against Arbovirus Infections, a Primary Screen [AID1251, Type: screening]
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39
[SID24799695]
Chemical Genetic Screen to Identify Inhibitors of Mitochondrial Fusion - Primary Screen [AID1362, Type: screening]
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40
[SID24799695]
HTS to identify inhibitors of zVAD Induced Cell Death in L929 Cells. [AID1377, Type: screening]
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41
[SID24799695]
HCS to Identify Inhibitors of Dynein Mediated Cargo Transport on Microtubules. [AID1381, Type: screening]
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42
[SID24799695]
Potency Counterscreen qHTS for Inhibitors of Tau Fibril Formation, Fluorescence Polarization [AID1463, Type: confirmatory]
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43
[SID24799695]
EC50 Screen for small molecule probes relevant to Friedreich's ataxia, Single Dose and Dose Response [AID1465, Type: confirmatory]
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44
[SID24799695]
Potency qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia [AID1477, Type: confirmatory]
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45
[SID24799695]
Counterscreen for inhibitors of Janus kinase 2 mutant JAK2V617F: Cell-based high throughput assay to identify inhibitors of parental Ba/F3 cell viability. [AID1486, Type: screening]
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46
[SID24799695]
MLPCN Ras selective lethality-BJeLR viability [AID1554, Type: screening]
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47
[SID24799695]
IC50 A Cell Based Assay for the Identification of Lead Compounds with Anti-Viral Activity Against West Nile Virus [AID1621, Type: confirmatory]
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48
[SID24799695]
EC50 HCS for Compounds that Up-Regulate Insulin Promoter Activity in MIN6 Cells [AID1625, Type: confirmatory]
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49
[SID24799695]
IC50 High Throughput Screen to Identify Inhibitors of Mycobacterium tuberculosis H37Rv [AID1626, Type: confirmatory]
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50
[SID24799695]
IC50 HCS for Compounds that Down-Regulate Insulin Promoter Activity in MIN6 Cells [AID1628, Type: confirmatory]
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