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GNF-Pf-1134 (CID 16188433) - Compound BioActivity Data
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BioActivity Outcomes:
Active(119)
 
 
Inactive(613)
 
 
Inconclusive(44)
 
 
Unspecified(4)
 
 
Top Targets:
7TM GPCR Srx(23)
 
 
 
7TM GPCR Srsx(17)
 
 
 
Bcl-2 like(11)
 
 
alkPPc(10)
 
 
G-alpha(8)
 
 
 
BioAssay Types:
Screening(514)
 
 
 
 
Confirmatory(225)
 
 
 
 
 
Literature(19)
 
 
 
 
BioActivity Types:
Potency(149)
 
 
 
 
 
IC50(44)
 
 
 
 
EC50(22)
 
 
 
 
AC50(5)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 710    Data Row: 780   Total Pages: 39   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24784417]
EC50_uM 0.291Fluorescence Cell-Based Dose Response to Characterize Compounds Cytotoxic to RAS-Dependent BJ-TERT-LT-ST Fibroblast [AID2631, Type: confirmatory]
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2
[SID24784417]
Potency 0.4611A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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3
[SID24784417]
Potency 0.5805qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID24784417]
Potency 0.6513qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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5
[SID103711321]
EC50 0.99NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay [AID449704, Type: Literature]
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6
[SID103711321]
EC50 1.207NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay [AID449703, Type: Literature]
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7
[SID24784417]
IC50_Mean 1.39Dose response confirmation of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay [AID489035, Type: confirmatory]
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8
[SID24784417]
Potency 2.0749qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation in HepG2 cytotox [AID588382, Type: confirmatory]
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9
[SID24784417]
Potency 2.8184VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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10
[SID24784417]
AC50_uM 2.833Anti-Malarial Hsp90 Inhibitors Measured in Microorganism System Using Plate Reader - 2121-01_Inhibitor_Dose_CherryPick_Activity [AID540268, Type: confirmatory]HSP90 [Plasmodium falciparum 3D7] [gi:124809506]
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11
[SID24784417]
Potency 3.5481qHTS for Inhibitors of the vitamin D receptor (VDR): Hit Validation using a Fluorescein Assay [AID602200, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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12
[SID24784417]
Potency 3.5481qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase plasminogen activator surface receptor precursor [Mus musculus] [gi:7242179]
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13
[SID24784417]
Potency 3.5481qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]plasminogen precursor [Mus musculus] [gi:257471003]
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14
[SID24784417]
Potency 3.5481Confirmation screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504848, Type: confirmatory]
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15
[SID24784417]
Potency 3.5481qHTS for Inhibitors of Cell Surface uPA Generation [AID540303, Type: confirmatory]urokinase-type plasminogen activator precursor [Mus musculus] [gi:6679377]
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16
[SID24784417]
AC50_uM 3.661Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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17
[SID24784417]
Potency 3.6626qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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18
[SID24784417]
Potency 3.9811Confirmation screen for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504850, Type: confirmatory]
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19
[SID24784417]
AC50_uM 4.227HsHsp90 Counterscreen Measured in Microorganism System Using Plate Reader - 2121-02_Inhibitor_Dose_CherryPick_Activity [AID540270, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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20
[SID24784417]
AC50_uM 4.615ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
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