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N-Methyl-3,4-methylenedioxyamphetamine (CID 1615) - Compound BioActivity Data
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BioActivity Outcomes:
Active(19)
 
 
Inactive(5)
 
 
Unspecified(41)
 
 
Top Targets:
p450(10)
 
 
 
SLC6sbd SERT(7)
 
 
 
SLC6sbd NET(2)
 
 
SLC6sbd DAT1(2)
 
 
Glutaminase(1)
 
 
BioAssay Types:
Literature(60)
 
 
 
Confirmatory(5)
 
 
BioActivity Types:
EC50(12)
 
 
 
IC50(9)
 
 
Potency(5)
 
 
Ki(4)
 
 
 
Kd(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 65    Data Row: 65   Total Pages: 2   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103225016]
Kd 0.000123Binding affinity was determined towards serotonin uptake site in presence of [3H]paroxetine radioligand in rat brain cortical homogenate [AID51042, Type: Literature]
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2
[SID103225016]
Kd 0.000195Binding affinity was determined towards serotonin uptake site in presence of [3H]paroxetine radioligand in rat hippocampal homogenate [AID51043, Type: Literature]
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3
[SID103225016]
Ki 0.00073Displacement of [3H]citalopram from human SERT expressed in HEK293 cells [AID408801, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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4
[SID103225016]
Ki 0.00203Displacement of [3H]paroxetine from human SERT expressed in HEK293 cells [AID408802, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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5
[SID103225016]
IC50 0.405Inhibition of human noradrenaline transporter [AID471667, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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6
[SID103225016]
IC50 0.405Binding affinity to human NET [AID488693, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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7
[SID103225016]
IC50 0.425Binding affinity to human SERT [AID488692, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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8
[SID103225016]
IC50 0.425Inhibition of [3H]5-HT uptake at SERT [AID471666, Type: Literature]
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9
[SID103225016]
IC50 1.06Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation counting [AID471630, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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10
[SID103225016]
IC50 1.1Inhibition of [3H]-serotonin reuptake at human SERT expressed in HEK293 cells after 15 to 20 mins by fluorescence neurotransmitter transporter assay [AID576813, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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11
[SID103225016]
IC50 1.442Binding affinity to human DAT [AID488694, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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12
[SID103225016]
IC50 1.442Inhibition of human dopamine transporter [AID471668, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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13
[SID103225016]
EC50 1.7Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by competitive binding assay [AID635290, Type: Literature]Trace amine-associated receptor 1 [gi:38258290]
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14
[SID103225016]
Km 1.9Michaelis-Menten constant for oxidation to 3,4-OH-MA by cytochrome P450 2D6 (wild type pSP19T7LT) [AID254565, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
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15
[SID103225016]
Km 11.2Michaelis-Menten constant for oxidation to N-OH-MDMA by cytochrome P450 2D6 (Phe120Ala mutant) [AID256546, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
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16
[SID103225016]
Km 11.8Michaelis-Menten constant for oxidation to 3,4-OH-MA by cytochrome P450 2D6 (Phe120Ala mutant) [AID256545, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
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17
[SID103225016]
Km 14.5Michaelis-Menten constant for oxidation to MDA by cytochrome P450 2D6 (Phe120Ala mutant) [AID256544, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
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18
[SID103225016]
EC50 32.3594Induction of human SERT-dependent cytotoxicity in SERT expressing human DG75 cells after 48 hrs by neutral red assay [AID471638, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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19
[SID103225016]
IC50 Cytotoxicity against human chemoresistant DG75 cells expressing SERT assessed as decrease in cell viability 10 or 50 uM after 72 hrs Alamar blue assay [AID576805, Type: Literature]
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20
[SID103225016]
Ki 12.9Mechanism based inhibition of human cytochrome P450 2D6 measured by dextromethorphan O-demethylation using recombinant CYP2D6 [AID589099, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
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21
[SID103225016]
Ki 22.8Mechanism based inhibition of human cytochrome P450 2D6 measured by dextromethorphan O-demethylation using human liver microsomes [AID589098, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
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22
[SID103225016]
EC50 245.471Cytotoxicity against human HEK293 cells after 48 hrs by neutral red assay [AID471634, Type: Literature]
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23
[SID103225016]
EC50 245.471Cytotoxicity against human HEK293 cells assessed as cell viability after 48 hrs by neutral red assay [AID488695, Type: Literature]
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24
[SID103225016]
EC50 251.189Cytotoxicity against human HEK293 cells assessed as decrease in cell viability after 48 hrs neutral red dye assay [AID576811, Type: Literature]
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25
[SID103225016]
EC50 489.779Cytotoxicity against human HEK293 cells over expressing human SERT assessed as cell viability after 48 hrs by neutral red assay [AID488696, Type: Literature]
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26
[SID103225016]
EC50 489.779Induction of human SERT-dependent cytotoxicity in SERT expressing HEK293 cells after 48 hrs by neutral red assay [AID471635, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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27
[SID103225016]
EC50 501.187Cytotoxicity against human HEK293 cells expressing human SERT assessed as decrease in cell viability after 48 hrs neutral red dye assay [AID576812, Type: Literature]
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28
[SID103225016]
EC50 1548.82Cytotoxicity against human HEK293 cells over expressing human NET assessed as cell viability after 48 hrs by neutral red assay [AID488697, Type: Literature]
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29
[SID103225016]
EC50 1949.84Cytotoxicity against human HEK293 cells over expressing human DAT assessed as cell viability after 48 hrs by neutral red assay [AID488698, Type: Literature]
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30
[SID103225016]
EC50 10000Cytotoxicity against human SH-SY5Y cells expressing human SERT assessed as decrease in cell viability after 48 hrs neutral red dye assay [AID576803, Type: Literature]
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31
[SID103225016]
EC50 10000Cytotoxicity against human SH-SY5Y cells after 48 hrs by neutral red assay [AID471639, Type: Literature]
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32
[SID103225016]
Compounds were evaluated for binding of [3H]paroxetine to rat brain cortical homogenate and number of binding sites (Bmax) for serotonin [AID51041, Type: Literature]
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33
[SID103225016]
Compounds were evaluated for binding of [3H]paroxetine to rat hippocampal homogenate and number of binding sites (Bmax) for serotonin [AID88606, Type: Literature]
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34
[SID103225016]
Percentage of animals disrupted was determined in groups of MDMA trained rats at a dose of 0.95 (umol/kg),(no of animals = 8) [AID175193, Type: Literature]
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35
[SID103225016]
Percentage of animals disrupted was determined in groups of MDMA trained rats at a dose of 1.90 (umol/kg),(no of animals = 8) [AID175194, Type: Literature]
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36
[SID103225016]
Percentage of animals disrupted was determined in groups of MDMA trained rats at a dose of 3.81 (umol/kg),(no of animals = 8) [AID175195, Type: Literature]
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37
[SID103225016]
Percentage of animals disrupted was determined in groups of MDMA trained rats at a dose of 7.62 (umol/kg),(no of animals = 8) [AID175196, Type: Literature]
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38
[SID103225016]
Inhibitory activity was determined MDMA trained rats [AID176238, Type: Literature]
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39
[SID103225016]
Effective dose was evaluated for drug discrimination in I-trained rats [AID178743, Type: Literature]
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40
[SID103225016]
Monoamine levels in at hippocampus were evaluated after subcutaneous administration of 40 mg/kg for NE [AID184513, Type: Literature]
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41
[SID103225016]
Monoamine levels in rat brain were evaluated after subcutaneous administration of 40 mg/kg for 5-HIAA [AID184514, Type: Literature]
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42
[SID103225016]
Monoamine levels in rat brain were evaluated after subcutaneous administration of 40 mg/kg for 5-HT [AID184515, Type: Literature]
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43
[SID103225016]
Monoamine levels in rat brain were evaluated after subcutaneous administration of 40 mg/kg for DA [AID184516, Type: Literature]
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44
[SID103225016]
Monoamine levels in rat brain were evaluated after subcutaneous administration of 40 mg/kg for DOPAC [AID184517, Type: Literature]
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45
[SID103225016]
Monoamine levels in rat brain were evaluated after subcutaneous administration of 40 mg/kg for HVA [AID184518, Type: Literature]
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46
[SID103225016]
Monoamine levels in rat brain were evaluated after subcutaneous administration of 40 mg/kg for NE [AID184519, Type: Literature]
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47
[SID103225016]
Monoamine levels in rat hippocampus were evaluated after subcutaneous administration of 40 mg/kg for 5-HIAA [AID184520, Type: Literature]
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48
[SID103225016]
Monoamine levels in rat hippocampus were evaluated after subcutaneous administration of 40 mg/kg for 5-HT [AID184521, Type: Literature]
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49
[SID103225016]
Tested for stimulus generation in rats trained to discriminate MDMA from saline at a dose 1.90 (umol/kg) (number of animals = 8) [AID190256, Type: Literature]
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50
[SID103225016]
Tested for stimulus generation in rats trained to discriminate MDMA from saline at a dose 3.81 (umol/kg),(number of animals = 8) [AID190257, Type: Literature]
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