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N-Methyl-3,4-methylenedioxyamphetamine (CID 1615) - Compound BioActivity Data
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BioActivity Outcomes:
Active(22)
 
 
Inactive(5)
 
 
Unspecified(42)
 
 
Top Targets:
p450(10)
 
 
 
SLC6sbd SERT(8)
 
 
 
SLC6sbd NET(3)
 
 
SLC6sbd DAT1(3)
 
 
Glutaminase(1)
 
 
BioAssay Types:
Literature(63)
 
 
 
Confirmatory(5)
 
 
BioActivity Types:
EC50(12)
 
 
 
IC50(12)
 
 
Potency(5)
 
 
Ki(4)
 
 
 
Kd(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 69    Data Row: 69   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103225016]
Kd 0.000123Binding affinity was determined towards serotonin uptake site in presence of [3H]paroxetine radioligand in rat brain cortical homogenate [AID51042, Type: Literature]
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2
[SID103225016]
Kd 0.000195Binding affinity was determined towards serotonin uptake site in presence of [3H]paroxetine radioligand in rat hippocampal homogenate [AID51043, Type: Literature]
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3
[SID103225016]
Ki 0.00073Displacement of [3H]citalopram from human SERT expressed in HEK293 cells [AID408801, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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4
[SID103225016]
Ki 0.00203Displacement of [3H]paroxetine from human SERT expressed in HEK293 cells [AID408802, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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5
[SID103225016]
IC50 0.405Inhibition of human noradrenaline transporter [AID471667, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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6
[SID103225016]
IC50 0.405Binding affinity to human NET [AID488693, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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7
[SID103225016]
IC50 0.425Inhibition of [3H]5-HT uptake at SERT [AID471666, Type: Literature]
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8
[SID103225016]
IC50 0.425Binding affinity to human SERT [AID488692, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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9
[SID103225016]
IC50 1.06Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation counting [AID471630, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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10
[SID103225016]
IC50 1.1Inhibition of [3H]-serotonin reuptake at human SERT expressed in HEK293 cells after 15 to 20 mins by fluorescence neurotransmitter transporter assay [AID576813, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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11
[SID103225016]
IC50 1.442Inhibition of human dopamine transporter [AID471668, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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12
[SID103225016]
IC50 1.442Binding affinity to human DAT [AID488694, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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13
[SID103225016]
EC50 1.7Activation of rat TAAR1 expressed in HEK293 cells assessed as accumulation of [3H]cAMP after 1 hr by competitive binding assay [AID635290, Type: Literature]Trace amine-associated receptor 1 [gi:38258290]
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14
[SID103225016]
Km 1.9Michaelis-Menten constant for oxidation to 3,4-OH-MA by cytochrome P450 2D6 (wild type pSP19T7LT) [AID254565, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
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15
[SID103225016]
IC50 1.99526Inhibition of [3H]norepinephrine uptake at human NET expressed in HEK293 cells preincubated for 10 mins prior to substrate addition measured after 4 mins by FLIPR assay [AID752492, Type: Literature]Sodium-dependent noradrenaline transporter [gi:128616]
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16
[SID103225016]
IC50 2.39883Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cells preincubated for 10 mins prior to substrate addition measured after 4 mins by FLIPR assay [AID752493, Type: Literature]Sodium-dependent dopamine transporter [gi:266667]
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17
[SID103225016]
IC50 2.75423Inhibition of [3H]5-HT uptake at human SERT expressed in HEK293 cells preincubated for 10 mins prior to substrate addition measured after 4 mins by FLIPR assay [AID752491, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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18
[SID103225016]
Km 11.2Michaelis-Menten constant for oxidation to N-OH-MDMA by cytochrome P450 2D6 (Phe120Ala mutant) [AID256546, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
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19
[SID103225016]
Km 11.8Michaelis-Menten constant for oxidation to 3,4-OH-MA by cytochrome P450 2D6 (Phe120Ala mutant) [AID256545, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
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20
[SID103225016]
Km 14.5Michaelis-Menten constant for oxidation to MDA by cytochrome P450 2D6 (Phe120Ala mutant) [AID256544, Type: Literature]Cytochrome P450 2D6 [gi:84028191]
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