Bookmark and Share

BioActivity Data for Compound GSK248233A (CID 16099859)

BioActivity Outcomes:
Active(3)
 
 
Inactive(11)
 
 
Inconclusive(1)
 
 
Unspecified(465)
 
 
Top Targets:
PTKc Abl(16)
 
 
PTKc EGFR(10)
 
 
PKc like(10)
 
 
STKc RSK N(8)
 
 
PTKc Kit(8)
 
 
BioAssay Types:
Literature(14)
 
 
 
 
Confirmatory(5)
 
 
 
 
BioAssay Categories:
In vitro(457)
 
 
 
In vivo(6)
 
 
Biochemical(460)
 
 
 
ADME(6)
 
 
Cell-based(1)
 
 
BioActivity Types:
Potency(7)
 
 
 
 
AC50(2)
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 480    Data Row: 480   Total Pages: 24   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103504607]
IC50 0.002Inhibition of human ROCK1 in Sf9 cells [AID275148, Type: Literature]Rho-associated protein kinase 1 [gi:47605999]
View
2
[SID103504607]
IC50 0.106Relaxation of phenylephrine contracted Sprague-Dawley rat aortic rings [AID275154, Type: Literature]
View
3
[SID124349910]
Potency 1.0312qHTS Assay for Inhibitors of Firefly Luciferase from the GSK Published Protein Kinase Inhibitor Set [AID652016, Type: confirmatory]Luciferase [Photinus pyralis] [gi:160794]
View
4
[SID103504607]
AC50 1.0312GSK_PKIS: Inhibition of Firefly Luciferase (Data from PubChem: AID 652016) [NIH NCATS] [AID720835, Type: Literature]Luciferin 4-monooxygenase [gi:126501]
View
5
[SID103504607]
AC50 GSK_PKIS: Inhibition of Sea Pansy Luciferase (Data from PubChem: AID 652015) [NIH NCATS] [AID720834, Type: Literature]Renilla-luciferin 2-monooxygenase [gi:126502]
View
6
[SID103504607]
GSK_PKIS: PDGFRB mean inhibition at 0.1 uM [Nanosyn] [AID651298, Type: other]Platelet-derived growth factor receptor beta [gi:129890]
View
7
[SID103504607]
GSK_PKIS: PDGFRB mean inhibition at 1 uM [Nanosyn] [AID651299, Type: other]Platelet-derived growth factor receptor beta [gi:129890]
View
8
[SID103504607]
GSK_PKIS: PDGFRA (D842V mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651292, Type: other]Platelet-derived growth factor receptor alpha [gi:129892]
View
9
[SID103504607]
GSK_PKIS: PDGFRA mean inhibition at 1 uM [Nanosyn] [AID651291, Type: other]Platelet-derived growth factor receptor alpha [gi:129892]
View
10
[SID103504607]
GSK_PKIS: PDGFRA (T674I mutant) mean inhibition at 1 uM [Nanosyn] [AID651295, Type: other]Platelet-derived growth factor receptor alpha [gi:129892]
View
11
[SID103504607]
GSK_PKIS: PDGFRA (D842V mutant) mean inhibition at 1 uM [Nanosyn] [AID651293, Type: other]Platelet-derived growth factor receptor alpha [gi:129892]
View
12
[SID103504607]
GSK_PKIS: PDGFRA (T674I mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651294, Type: other]Platelet-derived growth factor receptor alpha [gi:129892]
View
13
[SID103504607]
GSK_PKIS: PDGFRA (V561D mutant) mean inhibition at 0.1 uM [Nanosyn] [AID651296, Type: other]Platelet-derived growth factor receptor alpha [gi:129892]
View
14
[SID103504607]
GSK_PKIS: PDGFRA (V561D mutant) mean inhibition at 1 uM [Nanosyn] [AID651297, Type: other]Platelet-derived growth factor receptor alpha [gi:129892]
View
15
[SID103504607]
GSK_PKIS: PDGFRA mean inhibition at 0.1 uM [Nanosyn] [AID651290, Type: other]Platelet-derived growth factor receptor alpha [gi:129892]
View
16
[SID103504607]
Selectivity for ROCK1 over MSK1 [AID275151, Type: Literature]
View
17
[SID103504607]
Selectivity for ROCK1 over p70S6K [AID275150, Type: Literature]
View
18
[SID103504607]
Selectivity for ROCK1 over RSK1 [AID275149, Type: Literature]
View
19
[SID103504607]
Oral bioavailability in Sprague-Dawley rat at 2 mg/kg, po [AID275174, Type: Literature]
View
20
[SID103504607]
Volume of distribution in Sprague-Dawley rat at 0.85 mg/kg [AID275173, Type: Literature]
View