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Dronabinol (CID 16078) - Compound BioActivity Data
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BioActivity Outcomes:
Active(69)
 
 
Inactive(43)
 
 
Inconclusive(25)
 
 
Unspecified(169)
 
 
Top Targets:
7TM GPCR Srsx(14)
 
 
 
 
NR LBD AR(7)
 
 
 
NR LBD ER(7)
 
 
 
NR LBD GR(4)
 
 
NR LBD TR(3)
 
 
 
BioAssay Types:
Literature(222)
 
 
 
 
 
Confirmatory(48)
 
 
 
 
Summary(15)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Potency(61)
 
 
 
 
Ki(37)
 
 
IC50(7)
 
 
EC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 306    Data Row: 306   Total Pages: 7   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103167825]
EC50 0.0015Agonist activity at cloned human CB2 receptor in Sf9 cells assessed as stimulation of [35S]GTPgammaS binding assay [AID406792, Type: Literature]Cannabinoid receptor 2 [gi:461697]
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2
[SID103167825]
IC50 0.0028Displacement of [3H]CP55940 from human recombinant CB1 receptor expressed in HEK293 cells after 90 mins [AID636834, Type: Literature]Cannabinoid receptor 1 [gi:115562]
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3
[SID103167825]
Ki 0.0029Displacement of [3H]CP-55940 from human CB1 receptor [AID406791, Type: Literature]Cannabinoid receptor 1 [gi:115562]
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4
[SID103167825]
Ki 0.0033Binding affinity to human CB2 receptor [AID299499, Type: Literature]Cannabinoid receptor 2 [gi:461697]
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5
[SID103167825]
IC50 0.004In vitro inhibition of electrically induced contractions in isolated mouse vas deferens (MVD) preparations. [AID132488, Type: other]
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6
[SID103167825]
IC50 0.004Concentration required to inhibit electrically induced contractions in isolated mouse vas deferens preparation in vitro [AID138344, Type: Literature]
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7
[SID103167825]
IC50 0.0058Concentration of compound required to inhibit 50% of [3H]WIN-55212 binding to Cannabinoid receptor 1 in rat cerebellum membranes. [AID49481, Type: Literature]
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8
[SID103167825]
IC50 0.0058Compound was evaluated for the inhibition of [3H]WIN-55212-2 binding in rat cerebellum membranes [AID48997, Type: other]
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9
[SID103167825]
Ki 0.0092Binding affinity to mouse CB2 receptor [AID299503, Type: Literature]Cannabinoid receptor 2 [gi:1345700]
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10
[SID103167825]
IC50 0.0095Displacement of [3H]CP55940 from human recombinant CB2 receptor expressed in HEK293 cells after 90 mins [AID636835, Type: Literature]Cannabinoid receptor 2 [gi:461697]
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11
[SID103167825]
Ki 0.01Displacement of [3H]-CP55,940 from human CB1 receptor expressed in HEK293 cells [AID646621, Type: Literature]Cannabinoid receptor 1 [gi:115562]
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12
[SID103167825]
EC50 0.011Effective concentration for inhibition of Cannabinoid receptor 1-mediated adenylylcyclase activity using African green monkey (COS-7) cells transfected with the cDNA of rat CB1 receptor [AID49474, Type: Literature]
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13
[SID103167825]
EC50 0.017Agonist activity at human CB1 receptor expressed in HEK293 EBNA cells by [35S]GTPgamma binding assay [AID646622, Type: Literature]Cannabinoid receptor 1 [gi:115562]
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14
[SID103167825]
Ki 0.017Binding affinity to human CB1 receptor [AID299500, Type: Literature]Cannabinoid receptor 1 [gi:115562]
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15
[SID103167825]
Ki 0.02Binding affinity for cannabinoid receptor 2 [AID238321, Type: Literature]
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16
[SID103167825]
Ki 0.024Binding affinity to human CB2 receptor [AID646624, Type: Literature]Cannabinoid receptor 2 [gi:461697]
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17
[SID103167825]
Ki 0.025Binding affinity towards Cannabinoid receptor 2 using CP-55940 as radioligand in HEK293 EBNA cells [AID49845, Type: Literature]
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18
[SID103167825]
Ki 0.0285Binding affinity towards Cannabinoid receptor 1 using CP-55940 as radioligand in HEK293 EBNA cells [AID49314, Type: Literature]
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19
[SID103167825]
Ki 0.0322Binding affinity to Cannabinoid receptor 2 using African green monkey (COS-7) cells Chinese hamster ovary(CHO) cells transfected with the cDNA of human CB2 [AID49843, Type: Literature]
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20
[SID103167825]
Ki 0.036Binding affinity was determined for Cannabinoid receptor 2 [AID49846, Type: Literature]
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21
[SID103167825]
Ki 0.036Ability to bind with Cannabinoid receptor 2 using [H]CP-55940 as radioligand from cloned human receptor preparation [AID49832, Type: Literature]
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22
[SID103167825]
Ki 0.036Binding affinity to human CB2 receptor by filtration assay [AID714692, Type: Literature]Cannabinoid receptor 2 [gi:461697]
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23
[SID103167825]
Ki 0.036Binding affinity to displace [3H]CP-55940 from cloned human CB2 receptor [AID238759, Type: Literature]Cannabinoid receptor 2 [gi:461697]
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24
[SID103167825]
Ki 0.036Displacement of [3H]CP-55940 from human cloned CB2 receptor [AID326577, Type: Literature]Cannabinoid receptor 2 [gi:461697]
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25
[SID103167825]
Ki 0.036Displacement of [3H]CP-55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrometry analysis [AID497599, Type: Literature]Cannabinoid receptor 2 [gi:461697]
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26
[SID103167825]
Ki 0.036Displacement of [3H]CP-55940 from human CB2 receptor expressed in CHO cells after 1 hr by liquid scintillation spectrophotometry [AID537504, Type: Literature]Cannabinoid receptor 2 [gi:461697]
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27
[SID103167825]
Ki 0.036Displacement of [3H]CP-55940 from CB2 receptor [AID459824, Type: Literature]
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28
[SID103167825]
Ki 0.037Binding affinity for cannabinoid receptor 1 [AID238320, Type: Literature]
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29
[SID103167825]
Ki 0.0393Compound was evaluated for its ability to displace specifically bound [3H]CP-55940 from a Cannabinoid receptor 2 enriched mouse spleen preparation. [AID49856, Type: Literature]
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30
[SID103167825]
Ki 0.04Displacement of [3H]CP-55940 from CB1 receptor [AID459553, Type: Literature]
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31
[SID103167825]
Ki 0.04Binding affinity to mouse CB1 receptor [AID299504, Type: Literature]Cannabinoid receptor 1 [gi:1345697]
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32
[SID103167825]
Ki 0.041Displacement of [3H]CP-55940 from human CB2 receptor [AID406790, Type: Literature]Cannabinoid receptor 2 [gi:461697]
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33
[SID103167825]
Ki 0.041Displacement of [3H]CP-55940 from CB1 receptor in Sprague-Dawley rat brain membrane [AID326576, Type: Literature]Cannabinoid receptor 1 [gi:115563]
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34
[SID103167825]
Ki 0.041Displacement of [3H]CP-55940 from CB1 receptor in Sprague-Dawley rat brain cortex membranes [AID497598, Type: Literature]Cannabinoid receptor 1 [gi:115563]
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35
[SID103167825]
Ki 0.041Displacement of [3H]CP-55940 from CB1 receptor in Sprague-Dawley rat brain membranes after 1 hr by liquid scintillation spectrophotometry [AID537503, Type: Literature]Cannabinoid receptor 1 [gi:115563]
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36
[SID103167825]
Ki 0.041Displacement of [3H]CP55940 from CB1 receptor [AID714693, Type: Literature]
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37
[SID103167825]
Ki 0.041Evaluated for its binding affinity towards Cannabinoid receptor 1 (CB1) [AID49684, Type: Literature]
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38
[SID103167825]
Ki 0.041Compound was evaluated for Pharmacological response in the Cannabinoid receptor 1 [AID49687, Type: Literature]
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39
[SID103167825]
Ki 0.041Binding affinity for Cannabinoid receptor 1 in absence of phenylmethylsulfonyl fluoride (PMSF) [AID49469, Type: Literature]
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40
[SID103167825]
Ki 0.041Binding affinity was determined for Cannabinoid receptor 1 [AID49315, Type: Literature]
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41
[SID103167825]
Ki 0.041Binding affinity was determined in vitro against cannabinoid receptor by ability to displace [3H]CP-55940 [AID49150, Type: other]
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42
[SID103167825]
Ki 0.041Binding affinity to displace [3H]CP-55940 from CB1 receptor of rat brain [AID238758, Type: Literature]
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43
[SID103167825]
Ki 0.046Compound was evaluated for the competitive inhibition of [3H]3-(1,1-Dimethyl-heptyl)-9-hydroxymethyl-6,6-dimethyl-6a,7,8,9,10,10a-hexahydro-6H-benzo[c]chromen-1-ol to cannabinoid receptor from synaptosomal membranes of rat whole brain [AID49144, Type: Literature]
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44
[SID103167825]
Ki 0.0476Compound was evaluated for its ability to displace specifically bound [3H]CP-55940 from a Cannabinoid receptor 1 enriched rat brain microsome preparation. [AID49663, Type: Literature]
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45
[SID103167825]
Ki 0.0665Binding affinity for Cannabinoid receptor 1 using African green monkey (COS-7) cells transfected with the cDNA of rat brain synaptosomal membrane preparations. [AID49492, Type: Literature]
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46
[SID103167825]
Ki 0.0803Binding to Cannabinoid receptor 1 using African green monkey (COS-7) cells transfected with the cDNA of rat CB1. [AID49662, Type: Literature]
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47
[SID103167825]
IC50 0.218The compound was tested in vitro for binding activity against THC cannabinoid receptor site, using 3H-CP-55940 as the radioligand [AID49003, Type: Literature]
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48
[SID103167825]
EC50 0.23Agonist activity at rat TRPA1 channel expressed in HEK293 cells assessed as increase in intracellular calcium influx [AID482146, Type: Literature]Transient receptor potential cation channel subfamily A member 1 [gi:56749669]
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49
[SID144206169]
Potency-Replicate_1 3.7578qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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50
[SID144206169]
Ratio Potency (uM) 4.98946qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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