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5-hydroxyindole (CID 16054) - Compound BioActivity Data
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BioActivity Outcomes:
Active(9)
 
 
Inactive(813)
 
 
Inconclusive(14)
 
 
Unspecified(11)
 
 
Top Targets:
7TM GPCR Srx(26)
 
 
 
7TM GPCR Srsx(21)
 
 
alkPPc(16)
 
 
Bcl-2 like(12)
 
 
Tryp SPc(11)
 
 
BioAssay Types:
Screening(553)
 
 
 
 
 
Confirmatory(260)
 
 
 
 
 
Literature(16)
 
 
 
 
 
BioActivity Types:
Potency(171)
 
 
 
 
 
IC50(60)
 
 
 
 
 
EC50(10)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 779    Data Row: 847   Total Pages: 17   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID865950]
IC50 2.23A biochemical assay using the ADP-Hunter methodology, purified TAg, and ATP to identify compounds that inhibit the ATPase activity of Tag - Counter Screen [AID2501, Type: confirmatory]
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2
[SID865950]
Potency 8.1995A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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3
[SID103578866]
IC50 13Antimelanogenic activity in mouse B16 cells assessed as inhibition of intracellular melanin accumulation after 2 days [AID428335, Type: Literature]
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4
[SID865950]
Potency 14.1254qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase Cleavage of Glycogen [AID2100, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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5
[SID865950]
IC50 80.22Identification of SV40 T antigen inhibitors: A route to novel anti-viral reagents [AID1903, Type: confirmatory]large T antigen [Simian virus 40] [gi:297591903]
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6
[SID865950]
qHTS Assay for Tau Filament Binding [AID596, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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7
[SID865950]
Antagonist of Human D 1 Dopamine Receptor: qHTS [AID504652, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
View
8
[SID865950]
Counter Screen for Glucose-6-Phosphate Dehydrogenase-based Primary Assay [AID1020, Type: screening]glucose-6-phosphate dehydrogenase [Leuconostoc mesenteroides] [gi:149631]
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9
[SID865950]
Leishmania major promastigote HTS [AID1063, Type: screening]
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10
[SID103578866]
IC50 68Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation [AID428332, Type: Literature]Tyrosinase [gi:152060989]
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11
[SID103578866]
IC50 1000Inhibition of peptidase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE [AID420374, Type: Literature]Leukotriene A-4 hydrolase [gi:126353]
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12
[SID103578866]
EC50 1000Activity at human alpha-7 nACh receptor expressed in Xenopus laevis oocyte assessed as increase in acetylcholine-induced current [AID321284, Type: Literature]Neuronal acetylcholine receptor subunit alpha-7 [gi:2506127]
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13
[SID103578866]
IC50 2000Inhibition of hydrolase activity of human recombinant LTA4H expressed in Escherichia coli BL21-AI/pRARE assessed as LTB4 formation by tandem quadrupole mass spectrometry [AID420375, Type: Literature]Leukotriene A-4 hydrolase [gi:126353]
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14
[SID865950]
Assay for HTS of Gi/Go-linked GPCRs using mGluR8: Primary Screening [AID488969, Type: screening]metabotropic glutamate receptor 8 [Rattus norvegicus] [gi:1575471]
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15
[SID865950]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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16
[SID103578866]
Inhibition of catecholase activity of tyrosinase in human HMVII cells assessed as dopachrome formation at 100 uM [AID428334, Type: Literature]Tyrosinase [gi:401235]
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17
[SID103578866]
Inhibition of electric eel AChE using acetylcholine iodide as substrate at 10'-4 M measured every 5 sec for 2 mins by Ellman's method [AID656681, Type: Literature]Acetylcholinesterase [gi:14916521]
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18
[SID103578866]
Inhibition of catecholase activity of tyrosinase in mouse B16 cells assessed as dopachrome formation at 100 uM [AID428333, Type: Literature]Tyrosinase [gi:152060989]
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19
[SID103578866]
Solubility in methanol [AID420373, Type: Literature]
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20
[SID103578866]
Cytotoxicity against mouse B16 cells assessed as cell viability at 20 uM after 2 days by tetrazolium reduction assay [AID428336, Type: Literature]
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21
[SID865950]
Potency 7.9433qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a [AID927, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
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22
[SID865950]
Potency 18.526Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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23
[SID24724302]
IC50 50Tumor Hsp90 Inhibitors Dose Response Confirmation [AID712, Type: confirmatory]heat shock protein HSP 90-alpha isoform 2 [Homo sapiens] [gi:154146191]
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24
[SID24724302]
IC50 50Tumor Hsp90 Inhibitors Dose Response Confirmation [AID712, Type: confirmatory]90-kda heat shock protein beta HSP90 beta [Homo sapiens] [gi:4261762]
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25
[SID865950]
Schistosoma Mansoni Peroxiredoxins (Prx2) [AID448, Type: confirmatory]thioredoxin peroxidase [Schistosoma mansoni] [gi:4325211]
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26
[SID865950]
Potency qHTS assay of beta-arrestin-biased ligands of beta2-adrenergic receptor [AID492947, Type: confirmatory]beta-2 adrenergic receptor [Homo sapiens] [gi:4501969]
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27
[SID865950]
HTS for Beta-2AR agonists via FAP method [AID504454, Type: screening]beta-2 adrenergic receptor [Homo sapiens] [gi:4501969]
View
28
[SID865950]
Luminescence-based primary cell-based high throughput screening assay to identify activators of the Aryl Hydrocarbon Receptor (AHR) [AID2796, Type: screening]aryl hydrocarbon receptor precursor [Homo sapiens] [gi:4502003]
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29
[SID865950]
uHTS identification of inhibitors of cullin neddylation in a TR-FRET assay [AID651699, Type: screening]NEDD8-activating enzyme E1 regulatory subunit isoform a [Homo sapiens] [gi:4502169]
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30
[SID865950]
Counterscreen for Oxytocin Receptor (OXTR) agonists: Fluorescence-based primary cell-based high throughput assay to identify agonists of the vasopressin 1 receptor (V1R) [AID2797, Type: screening]vasopressin V1a receptor [Homo sapiens] [gi:4502331]
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31
[SID865950]
Complement factor C1s [AID538, Type: screening]complement C1s subcomponent precursor [Homo sapiens] [gi:4502495]
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32
[SID865950]
IC50 Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay [AID2073, Type: confirmatory]voltage-dependent N-type calcium channel subunit alpha-1B isoform 1 [Homo sapiens] [gi:4502523]
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33
[SID865950]
IC50_Mean High Throughput Imaging Assay for Beta-Catenin [AID1665, Type: confirmatory]catenin beta-1 [Homo sapiens] [gi:4503131]
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34
[SID865950]
Cathepsin L [AID460, Type: screening]cathepsin L1 isoform 1 preproprotein [Homo sapiens] [gi:4503155]
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35
[SID865950]
CYP2C19 Assay [AID778, Type: screening]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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36
[SID865950]
HTS Assay for Activators of Cytochrome P450 2A19 [AID1025, Type: screening]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
View
37
[SID865950]
uHTS identification of DNMT1 inhibitors in a Fluorescent Molecular Beacon assay [AID588458, Type: screening]DNA (cytosine-5)-methyltransferase 1 isoform b [Homo sapiens] [gi:4503351]
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38
[SID865950]
Potentiators of Human D1 Dopamine Receptor: qHTS [AID504651, Type: screening]D(1A) dopamine receptor [Homo sapiens] [gi:4503383]
View
39
[SID865950]
Primary biochemical high-throughput screening assay for inhibitors of the c-Jun N-Terminal Kinase 3 (JNK3) [AID746, Type: screening]Mitogen-activated protein kinase 10 [gi:2507196]
View
40
[SID865950]
IC50 Homogeneous Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay [AID2073, Type: confirmatory]Mint1 [Rattus norvegicus] [gi:2625023]
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41
[SID865950]
Potency qHTS Assay for Activators of ClpP [AID651965, Type: confirmatory]ClpP [Bacillus subtilis] [gi:2668494]
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42
[SID865950]
ARNT-TAC3: AlphaScreen HTS to detect disruption of ARNT/TAC3 interactions Measured in Biochemical System Using Plate Reader - 2158-01_Inhibitor_SinglePoint_HTS_Activity [AID623870, Type: screening]aryl hydrocarbon receptor nuclear translocator [Homo sapiens] [gi:2702319]
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43
[SID865950]
TRFRET-based biochemical primary high throughput screening assay to identify inhibitors of HIV-1 LEDGF/p75 DNA Integration [AID743269, Type: screening]integrase [Human immunodeficiency virus 1] [gi:2853980]
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44
[SID865950]
Primary cell-based high-throughput screening assay for identification of compounds that allosterically potentiate transient receptor potential cation channel C4 (TRPC4) [AID2227, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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45
[SID865950]
Primary cell-based screen for identification of compounds that activate transient receptor potential cation channel C4 (TRPC4). [AID2237, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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46
[SID865950]
Primary cell-based screen for identification of compounds that inhibit transient receptor potential cation channel C4 (TRPC4). [AID2247, Type: screening]alternatively spliced Trp4 [Mus musculus] [gi:2935630]
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47
[SID865950]
Potency A Quantitative High throughput Screen to Identify Chemical Modulators of PINK1 Expression [AID624263, Type: confirmatory]Parkin [Homo sapiens] [gi:3063388]
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48
[SID865950]
Primary biochemical high-throughput screening assay for inhibitors of Focal Adhesion Kinase (FAK) [AID727, Type: screening]Focal adhesion kinase 1 [gi:3183518]
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49
[SID865950]
qHTS Assay for Inhibitors of RGS12 GoLoco Motif Activity (Red Fluorophore) [AID880, Type: confirmatory]RGS12 [Homo sapiens] [gi:3290016]
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50
[SID865950]
Potency qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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