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NVP-TAE684 (CID 16038120) - Compound BioActivity Data
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BioActivity Outcomes:
Active(828)
 
 
Inactive(73)
 
 
Inconclusive(2)
 
 
Unspecified(989)
 
 
Top Targets:
PTKc Abl(16)
 
 
PTKc EGFR(12)
 
 
PI3Kc IA alph..(10)
 
 
PKc like(9)
 
 
 
STAT bind(8)
 
 
BioAssay Types:
Literature(1506)
 
 
 
 
 
Confirmatory(381)
 
 
 
 
 
BioActivity Types:
Kd(444)
 
 
 
IC50(429)
 
 
 
 
Potency(21)
 
 
 
 
EC50(16)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1744    Data Row: 1892   Total Pages: 95   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103583785]
IC50 6.03e-05SANGER: Inhibition of human SCC-3 cell growth in a cell viability assay. [AID741847, Type: confirmatory]
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2
[SID103583785]
Kd 0.00049Binding constant for ROS1 kinase domain [AID624899, Type: Literature]Proto-oncogene tyrosine-protein kinase ROS [gi:126302596]
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3
[SID103583785]
IC50 0.000564SANGER: Inhibition of human SF539 cell growth in a cell viability assay. [AID741855, Type: confirmatory]
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4
[SID103583785]
Kd 0.00083Binding constant for ULK1 kinase domain [AID624916, Type: Literature]Serine/threonine-protein kinase ULK1 [gi:317373288]
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5
[SID103583785]
Kd 0.00085Binding constant for BMPR1B kinase domain [AID624825, Type: Literature]Bone morphogenetic protein receptor type-1B [gi:6226778]
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6
[SID103583785]
Kd 0.00086Binding constant for LRRK2(G2019S) kinase domain [AID624741, Type: Literature]Leucine-rich repeat serine/threonine-protein kinase 2 [gi:294862450]
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7
[SID103583785]
IC50 0.000927SANGER: Inhibition of human DEL cell growth in a cell viability assay. [AID742112, Type: confirmatory]
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8
[SID103583785]
Kd 0.00093Binding constant for PLK4 kinase domain [AID625076, Type: Literature]Serine/threonine-protein kinase PLK4 [gi:160113150]
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9
[SID103583785]
Kd 0.00095Binding constant for LTK kinase domain [AID624743, Type: Literature]Leukocyte tyrosine kinase receptor [gi:143811416]
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10
[SID103583785]
IC50 0.001Cytotoxicity against mouse BAF3 cells expressing Tel-ALK after 48 hrs by CellTiter-Glo assay [AID642888, Type: Literature]
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11
[SID103583785]
Kd 0.0011Binding constant for PYK2 kinase domain [AID624732, Type: Literature]Protein-tyrosine kinase 2-beta [gi:3183003]
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12
[SID103583785]
Kd 0.0011Binding constant for FAK kinase domain [AID624729, Type: Literature]Focal adhesion kinase 1 [gi:3183518]
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13
[SID103583785]
Kd 0.0011Binding constant for ALK kinase domain [AID624944, Type: Literature]ALK tyrosine kinase receptor [gi:296439447]
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14
[SID103583785]
Kd 0.0012Binding constant for SNARK kinase domain [AID625139, Type: Literature]NUAK family SNF1-like kinase 2 [gi:74761376]
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15
[SID103583785]
Kd 0.0014Binding constant for FER kinase domain [AID625010, Type: Literature]Tyrosine-protein kinase Fer [gi:97536202]
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16
[SID103583785]
Kd 0.0014Binding constant for LRRK2 kinase domain [AID624740, Type: Literature]Leucine-rich repeat serine/threonine-protein kinase 2 [gi:294862450]
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17
[SID103583785]
IC50 0.00162SANGER: Inhibition of human NB1 cell growth in a cell viability assay. [AID742387, Type: confirmatory]
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18
[SID103583785]
Kd 0.0018Binding constant for ULK2 kinase domain [AID625085, Type: Literature]Serine/threonine-protein kinase ULK2 [gi:296453001]
View
19
[SID103583785]
Kd 0.0018Binding constant for TNK1 kinase domain [AID624930, Type: Literature]Non-receptor tyrosine-protein kinase TNK1 [gi:116242821]
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20
[SID103583785]
Kd 0.002Binding constant for TNK2 kinase domain [AID624807, Type: Literature]Activated CDC42 kinase 1 [gi:229462980]
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