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NVP-TAE684 (CID 16038120) - Compound BioActivity Data
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BioActivity Outcomes:
Active(819)
 
 
Inactive(67)
 
 
Inconclusive(2)
 
 
Unspecified(986)
 
 
Top Targets:
PKc(48)
 
 
 
PKc like(40)
 
 
 
STKc AGC(17)
 
 
PTKc Abl(16)
 
 
PTKc EGFR(12)
 
 
BioAssay Types:
Literature(1492)
 
 
 
 
 
Confirmatory(16)
 
 
 
 
BioActivity Types:
Kd(442)
 
 
 
IC50(423)
 
 
 
 
Potency(17)
 
 
 
 
EC50(16)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1726    Data Row: 1874   Total Pages: 38   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103583785]
IC50 6.03e-05SANGER: Inhibition of human SCC-3 cell growth in a cell viability assay. [AID741847, Type: other]
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2
[SID103583785]
Kd 0.00049Binding constant for ROS1 kinase domain [AID624899, Type: Literature]Proto-oncogene tyrosine-protein kinase ROS [gi:126302596]
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3
[SID103583785]
IC50 0.000564SANGER: Inhibition of human SF539 cell growth in a cell viability assay. [AID741855, Type: other]
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4
[SID103583785]
Kd 0.00083Binding constant for ULK1 kinase domain [AID624916, Type: Literature]Serine/threonine-protein kinase ULK1 [gi:317373288]
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5
[SID103583785]
Kd 0.00085Binding constant for BMPR1B kinase domain [AID624825, Type: Literature]Bone morphogenetic protein receptor type-1B [gi:6226778]
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6
[SID103583785]
Kd 0.00086Binding constant for LRRK2(G2019S) kinase domain [AID624741, Type: Literature]Leucine-rich repeat serine/threonine-protein kinase 2 [gi:294862450]
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7
[SID103583785]
IC50 0.000927SANGER: Inhibition of human DEL cell growth in a cell viability assay. [AID742112, Type: other]
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8
[SID103583785]
Kd 0.00093Binding constant for PLK4 kinase domain [AID625076, Type: Literature]Serine/threonine-protein kinase PLK4 [gi:160113150]
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9
[SID103583785]
Kd 0.00095Binding constant for LTK kinase domain [AID624743, Type: Literature]Leukocyte tyrosine kinase receptor [gi:143811416]
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10
[SID103583785]
IC50 0.001Cytotoxicity against mouse BAF3 cells expressing Tel-ALK after 48 hrs by CellTiter-Glo assay [AID642888, Type: Literature]
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11
[SID103583785]
Kd 0.0011Binding constant for ALK kinase domain [AID624944, Type: Literature]ALK tyrosine kinase receptor [gi:296439447]
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12
[SID103583785]
Kd 0.0011Binding constant for PYK2 kinase domain [AID624732, Type: Literature]Protein-tyrosine kinase 2-beta [gi:3183003]
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13
[SID103583785]
Kd 0.0011Binding constant for FAK kinase domain [AID624729, Type: Literature]Focal adhesion kinase 1 [gi:3183518]
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14
[SID103583785]
Kd 0.0012Binding constant for SNARK kinase domain [AID625139, Type: Literature]NUAK family SNF1-like kinase 2 [gi:74761376]
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15
[SID103583785]
Kd 0.0014Binding constant for FER kinase domain [AID625010, Type: Literature]Tyrosine-protein kinase Fer [gi:97536202]
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16
[SID103583785]
Kd 0.0014Binding constant for LRRK2 kinase domain [AID624740, Type: Literature]Leucine-rich repeat serine/threonine-protein kinase 2 [gi:294862450]
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17
[SID103583785]
IC50 0.00162SANGER: Inhibition of human NB1 cell growth in a cell viability assay. [AID742387, Type: other]
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18
[SID103583785]
Kd 0.0018Binding constant for ULK2 kinase domain [AID625085, Type: Literature]Serine/threonine-protein kinase ULK2 [gi:296453001]
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19
[SID103583785]
Kd 0.0018Binding constant for TNK1 kinase domain [AID624930, Type: Literature]Non-receptor tyrosine-protein kinase TNK1 [gi:116242821]
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20
[SID103583785]
Kd 0.002Binding constant for TNK2 kinase domain [AID624807, Type: Literature]Activated CDC42 kinase 1 [gi:229462980]
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21
[SID103583785]
Kd 0.002Binding constant for FLT3(D835Y) kinase domain [AID624936, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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22
[SID103583785]
IC50 0.002Antiproliferative activity against human Karpas299 cells assessed as luciferase expression after 72 hrs [AID360948, Type: Literature]
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23
[SID103583785]
IC50 0.002Antiproliferative activity against human SUDHL1 cells assessed as luciferase expression after 72 hrs [AID360949, Type: Literature]
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24
[SID103583785]
Kd 0.0024Binding constant for INSR kinase domain [AID624784, Type: Literature]Insulin receptor [gi:308153655]
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25
[SID103583785]
Kd 0.0027Binding constant for IGF1R kinase domain [AID624800, Type: Literature]Insulin-like growth factor 1 receptor [gi:124240]
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26
[SID103583785]
IC50 0.00277SANGER: Inhibition of human SR cell growth in a cell viability assay. [AID741894, Type: other]
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27
[SID103583785]
IC50 0.003Antiproliferative activity against mouse Ba/F3 NPM-ALK cells assessed as luciferase expression after 2 to 3 days [AID360946, Type: Literature]
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28
[SID103583785]
IC50 0.003Induction of apoptosis in human Karpas299 cells by annexin V assay [AID360999, Type: Literature]
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29
[SID103583785]
EC50 0.003Inhibition of ALK by cellular assay [AID383109, Type: Literature]
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30
[SID103583785]
IC50 0.003Inhibition of FLT3 [AID383105, Type: Literature]
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31
[SID103583785]
IC50 0.003Cytotoxicity against mouse BAF3 cells expressing NPM-ALK after 48 hrs by CellTiter-Glo assay [AID642889, Type: Literature]
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32
[SID103583785]
Kd 0.0032Binding constant for STK33 kinase domain [AID625138, Type: Literature]Serine/threonine-protein kinase 33 [gi:74761329]
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33
[SID103583785]
Kd 0.0034Binding constant for EGFR(L858R,T790M) kinase domain [AID625004, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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34
[SID103583785]
IC50 0.004Inhibition of Tel-fused ALK kinase-mediated mouse BaF3 cell proliferation [AID360969, Type: Literature]
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35
[SID103583785]
Kd 0.0048Binding constant for FES kinase domain [AID624852, Type: Literature]Tyrosine-protein kinase Fes/Fps [gi:115502390]
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36
[SID103583785]
Kd 0.0049Binding constant for FLT3(D835H) kinase domain [AID624935, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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37
[SID103583785]
Kd 0.0049Binding constant for DCAMKL1 kinase domain [AID624966, Type: Literature]Serine/threonine-protein kinase DCLK1 [gi:6225242]
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38
[SID103583785]
Kd 0.0053Binding constant for GAK kinase domain [AID625012, Type: Literature]Cyclin-G-associated kinase [gi:17375734]
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39
[SID103583785]
Kd 0.0054Binding constant for ABL1(T315I)-phosphorylated kinase domain [AID624989, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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40
[SID124947877]
Potency 0.0055qHTS for small molecule inhibitors of Yes1 kinase: Primary Screen [AID686947, Type: Literature]tyrosine-protein kinase Yes [Homo sapiens] [gi:4885661]
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41
[SID103583785]
IC50 0.0061Inhibition of LRRK2 G2019S mutant expressed in HEK293 cells using nictide and ATP as substrate [AID653134, Type: Literature]
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42
[SID103583785]
Kd 0.0062Binding constant for INSRR kinase domain [AID625075, Type: Literature]Insulin receptor-related protein [gi:12644000]
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43
[SID103583785]
Kd 0.0071Binding constant for EGFR(T790M) kinase domain [AID625007, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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44
[SID103583785]
IC50 0.0078Inhibition of wild-type LRRK2 expressed in HEK293 cells using nictide and [gamma32]ATP as substrate [AID653133, Type: Literature]
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45
[SID103583785]
Kd 0.0082Binding constant for FLT3(K663Q) kinase domain [AID624938, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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46
[SID103583785]
Kd 0.0086Binding constant for FLT3(ITD) kinase domain [AID624937, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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47
[SID103583785]
IC50 0.01Decrease in ALK phosphorylation in human Karpas299 cells after 4 hrs [AID360953, Type: Literature]ALK tyrosine kinase receptor [gi:296439447]
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48
[SID103583785]
IC50 0.01Decrease in ALK phosphorylation in human SUDHL1 cells after 4 hrs [AID360954, Type: Literature]ALK tyrosine kinase receptor [gi:296439447]
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49
[SID103583785]
IC50 0.01Decrease in ALK phosphorylation in mouse Ba/F3 NPM-ALK cells after 4 hrs [AID360955, Type: Literature]ALK tyrosine kinase receptor [gi:341940209]
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50
[SID103583785]
Kd 0.011Binding constant for CAMKK2 kinase domain [AID625060, Type: Literature]Calcium/calmodulin-dependent protein kinase kinase 2 [gi:317373374]
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