Paraquat (CID 15938) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(6)
 
 
Inactive(1)
 
 
Unspecified(151)
 
 
Top Targets:
7TM GPCR Srx(12)
 
 
7TM GPCR Srsx(10)
 
 
p450(8)
 
 
SLC6sbd DAT1(3)
 
 
prostaglandin..(2)
 
 
BioAssay Types:
Literature(26)
 
 
 
 
BioActivity Types:
IC50(116)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 158    Data Row: 158   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103630533]
 Increase in ompX-lacZ expression in Escherichia coli JM109 assessed as ompX upregulation after 60 mins relative to control [AID369250, Type: Literature]
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2
[SID103630533]
 Increase in ompX-lacZ expression in Escherichia coli JM109 assessed as increase in beta-galactosidase activity after 60 mins relative to control [AID369251, Type: Literature]
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3
[SID103630533]
 Increase in ompX-lacZ expression in Enterobacter aerogenes ATCC 15038 assessed as ompX upregulation after 60 mins relative to control [AID369252, Type: Literature]
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4
[SID103630533]
 Increase in ompX-lacZ expression in Enterobacter aerogenes ATCC 15038 assessed as increase in beta-galactosidase activity after 60 mins relative to control [AID369253, Type: Literature]
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5
[SID103630533]
 Increase in ompX-lacZ expression in Escherichia coli deltaompX mutant assessed as increase in beta-galactosidase activity after 60 mins relative to control [AID369249, Type: Literature]
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6
[SID103630533]
 Phospholipidosis-positive literature compound observed in mouse [AID540238, Type: Literature]
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7
[SID103630533]
IC50 DRUGMATRIX: Nicotinic Acetylcholine radioligand binding (ligand: [125I] Epibatidine) [AID625158, Type: other]
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8
[SID103630533]
 Antibacterial activity against Escherichia coli KAM32 harboring plasmid pUC18 by CLSI broth microdilution method [AID571882, Type: Literature]
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9
[SID103630533]
 Induction of ompX transcription in SoxS-positive Escherichia coli K12 relative to control [AID369625, Type: Literature]
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10
[SID103630533]
 Antibacterial activity against Escherichia coli KAM32 harboring plasmid pUC18 by CLSI broth microdilution method in presence of 25 ug/ml efflux pump inhibitor CCCP [AID571883, Type: Literature]
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11
[SID103630533]
 Antibacterial activity against Escherichia coli KAM32 harboring recombinant plasmid pVBS1 encoding Acinetobacter baumannii abeS gene by CLSI broth microdilution method [AID571884, Type: Literature]
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12
[SID103630533]
 Antibacterial activity against Escherichia coli KAM32 harboring recombinant plasmid pVBS1 encoding Acinetobacter baumannii abeS gene by CLSI broth microdilution method in presence of 25 ug/ml efflux pump inhibitor CCCP [AID571885, Type: Literature]
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13
[SID103630533]
 Ratio of MIC for Escherichia coli KAM32 harboring plasmid pUC18 to MIC for Escherichia coli KAM32 harboring recombinant plasmid pVBS1 encoding Acinetobacter baumannii abeS gene [AID572058, Type: Literature]
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14
[SID103630533]
 Antibacterial activity against Acinetobacter baumannii AC0037 by CLSI broth microdilution method [AID572059, Type: Literature]
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15
[SID103630533]
 Antibacterial activity against abeS-deficient Acinetobacter baumannii AC0037 by CLSI broth microdilution method [AID572060, Type: Literature]
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16
[SID103630533]
 Ratio of MIC for Acinetobacter baumannii AC0037 to MIC for abeS-deficient Acinetobacter baumannii AC0037 [AID572061, Type: Literature]
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17
[SID103630533]
 Antibacterial activity against abeS sigma abeS-deficient Acinetobacter baumannii AC0037 by CLSI broth microdilution method [AID572062, Type: Literature]
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18
[SID103630533]
 Antimicrobial activity against AcrAB-deficient Escherichia coli AG100AX harboring pBADomeganorM plasmid containing Neisseria gonorrhoeae multidrug efflux pump NorM after 18 to 24 hrs by two fold dilution method [AID572147, Type: Literature]
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19
[SID103630533]
 Antimicrobial activity against AcrAB-deficient Escherichia coli AG100AX harboring pBAD plasmid after 18 to 24 hrs by two fold dilution method [AID572150, Type: Literature]
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20
[SID103630533]
 Antimicrobial activity against AcrAB-deficient Escherichia coli AG100AX harboring pBADomegaydhE plasmid containing Escherichia coli multidrug efflux pump YdhE after 18 to 24 hrs by two fold dilution method [AID572151, Type: Literature]
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21
[SID103630533]
 Literature-mined public compounds from Lowe et al phospholipidosis modelling dataset [AID588208, Type: Literature]
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22
[SID103630533]
 Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset [AID588209, Type: Literature]
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23
[SID103630533]
 Human drug-induced liver injury (DILI) modelling dataset from Ekins et al [AID588210, Type: Literature]
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24
[SID103630533]
 Literature-mined public compounds from Kruhlak et al phospholipidosis modelling dataset [AID588220, Type: Literature]
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25
[SID103630533]
 DRUGMATRIX: Phorbol Ester radioligand binding (ligand: [3H] PDBu) [AID625164, Type: other]
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26
[SID103630533]
IC50 DRUGMATRIX: Phosphodiesterase PDE3 enzyme inhibition (substrate: [3H]cAMP + cAMP) [AID625165, Type: other]
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27
[SID103630533]
IC50 DRUGMATRIX: Phosphodiesterase PDE4 enzyme inhibition (substrate: [3H]cAMP + cAMP) [AID625166, Type: other]
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28
[SID103630533]
 DRUGMATRIX: Platelet-Derived Growth Factor (PDGF) radioligand binding (ligand: [125I] PDGF) [AID625169, Type: other]
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29
[SID103630533]
IC50 DRUGMATRIX: Potassium Channel [KATP] radioligand binding (ligand: [3H] Glyburide) [AID625170, Type: other]
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30
[SID103630533]
 DRUGMATRIX: Purinergic P2X radioligand binding (ligand: [3H] alpha, beta-Methylene-ATP) [AID625189, Type: other]
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31
[SID103630533]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) [AID625190, Type: other]
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32
[SID103630533]
IC50 DRUGMATRIX: Sodium/nucleoside co-transporter radioligand binding (ligand: nitrobenzylthioinosine) [AID625197, Type: other]
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33
[SID103630533]
IC50 DRUGMATRIX: ATPase, Na+/K+ enzyme inhibition (substrate: ATP) [AID625210, Type: other]
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34
[SID103630533]
 DRUGMATRIX: Atrial Natriuretic Factor (ANF) radioligand binding (ligand: [125I] ANF (rat)) [AID625211, Type: other]
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35
[SID103630533]
IC50 DRUGMATRIX: beta-Lactamase enzyme inhibition (substrate: Nitrocefin) [AID625212, Type: other]
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36
[SID103630533]
IC50 DRUGMATRIX: Calcium Channel Type L, Benzothiazepine radioligand binding (ligand: [3H] Diltiazem) [AID625215, Type: other]
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37
[SID103630533]
IC50 DRUGMATRIX: Calcium Channel Type L, Dihydropyridine radioligand binding (ligand: [3H] Nitrendipine) [AID625216, Type: other]
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38
[SID103630533]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT3 radioligand binding (ligand: [3H] GR-65630) [AID625219, Type: other]
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39
[SID103630533]
IC50 DRUGMATRIX: Sigma2 radioligand binding (ligand: [3H] Ifenprodil) [AID625224, Type: other]
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40
[SID103630533]
IC50 DRUGMATRIX: Sodium Channel, Site 2 radioligand binding (ligand: [3H] Batrachotoxin) [AID625225, Type: other]
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41
[SID103630533]
 DRUGMATRIX: Tumor Necrosis Factor (TNF), Non-Selective radioligand binding (ligand: [125I] TNF-alpha) [AID625230, Type: other]
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42
[SID103630533]
IC50 DRUGMATRIX: Calcium Channel Type L, Phenylalkylamine radioligand binding (ligand: [3H] (-)-Desmethoxyverapamil (D-888)) [AID625234, Type: other]
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43
[SID103630533]
IC50 DRUGMATRIX: GABAA, Muscimol, Central radioligand binding (ligand: [3H] Muscimol) [AID625260, Type: other]
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44
[SID103630533]
IC50 DRUGMATRIX: GABAA, Flunitrazepam, Central radioligand binding (ligand: [3H] Flunitrazepam) [AID625261, Type: other]
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45
[SID103630533]
IC50 DRUGMATRIX: GABAA, Chloride Channel, TBOB radioligand binding (ligand: [3H] TBOB) [AID625262, Type: other]
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46
[SID103630533]
IC50 DRUGMATRIX: Glutamate, AMPA radioligand binding (ligand: [3H] AMPA) [AID625264, Type: other]
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47
[SID103630533]
 DRUGMATRIX: Glutamate, Kainate radioligand binding (ligand: [3H] Kainic acid) [AID625265, Type: other]
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48
[SID103630533]
IC50 DRUGMATRIX: Glutamate, NMDA, Agonism radioligand binding (ligand: [3H] CGP-39653) [AID625266, Type: other]
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49
[SID103630533]
IC50 DRUGMATRIX: Glutamate, NMDA, Phencyclidine radioligand binding (ligand: [3H] TCP) [AID625267, Type: other]
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50
[SID103630533]
IC50 DRUGMATRIX: Glycine, Strychnine-Sensitive radioligand binding (ligand: [3H] Strychnine) [AID625268, Type: other]
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