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BIRB 796 (CID 156422) - Compound BioActivity Data
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BioActivity Outcomes:
Active(421)
 
 
Inactive(330)
 
 
Inconclusive(32)
 
 
Unspecified(1374)
 
 
Top Targets:
PKc(102)
 
 
 
 
PKc like(99)
 
 
 
 
STKc AGC(47)
 
 
 
PTKc Abl(38)
 
 
 
 
PTKc EGFR(28)
 
 
 
 
BioAssay Types:
Literature(1395)
 
 
 
 
Confirmatory(161)
 
 
 
 
Summary(24)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Kd(896)
 
 
 
 
IC50(782)
 
 
 
Potency(105)
 
 
 
 
EC50(6)
 
 
Ki(5)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1951    Data Row: 2157   Total Pages: 44   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103320031]
Kd 4.6e-05Kd value and murine Mitogen-activated protein kinase p38 alpha complex was calculated [AID127268, Type: Literature]
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2
[SID103320031]
Kd 4.6e-05Dissociation constant at Tref against human Mitogen-activated protein kinase p38 alpha [AID127252, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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3
[SID103320031]
Kd 9.7e-05Binding affinity against human Mitogen-activated protein kinase p38 kinase evaluated by exchange curve [AID127075, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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4
[SID103320031]
Kd 9.7e-05Binding affinity against human Mitogen-activated protein kinase p38 kinase evaluated by exchange curve [AID127075, Type: Literature]Mitogen-activated protein kinase 12 [gi:2851522]
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5
[SID103320031]
Kd 9.7e-05Binding affinity against human Mitogen-activated protein kinase p38 kinase evaluated by exchange curve [AID127075, Type: Literature]Mitogen-activated protein kinase 13 [gi:6685642]
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6
[SID103320031]
Kd 9.7e-05Binding affinity against human Mitogen-activated protein kinase p38 kinase evaluated by exchange curve [AID127075, Type: Literature]Mitogen-activated protein kinase 11 [gi:134047835]
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7
[SID103320031]
Ki 9.7e-05Inhibition of p38alpha [AID512564, Type: Literature]
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8
[SID103320031]
Kd 9.8e-05Binding affinity for Mitogen-activated protein kinase p38 alpha [AID127260, Type: Literature]
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9
[SID103320031]
Kd 9.8e-05Binding affinity to full-length GST-tagged p38alpha by surface plasmon resonance assay [AID516348, Type: Literature]
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10
[SID103320031]
Ki 0.0001Inhibition of p38V kinase stie 3 delta 296-301 mutant [AID513132, Type: Literature]
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11
[SID103320031]
Kd 0.0001Binding affinity to p38alpha by exchange curve binding kinetic analysis [AID353469, Type: Literature]
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12
[SID103320031]
Kd 0.0001Dissociation constant at Tm against human Mitogen-activated protein kinase p38 alpha (fluorescence exchange curve) [AID127251, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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13
[SID103320031]
Kd 0.00016Inhibition of p38alpha [AID501375, Type: Literature]
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14
[SID103320031]
Kd 0.00024Average Binding Constant for p38-alpha ; NA=Not Active at 10 uM [AID256656, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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15
[SID103320031]
Kd 0.00037Binding constant for full-length p38-alpha [AID435181, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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16
[SID103320031]
Kd 0.00045Binding constant for p38-alpha kinase domain [AID624714, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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17
[SID103320031]
Kd 0.001Binding affinity to p38alpha MAPK by surface plasmon resonance method [AID639673, Type: Literature]
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18
[SID103320031]
Kd 0.0013Dissociation constant at Tm against human Mitogen-activated protein kinase p38 alpha [AID127249, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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19
[SID103320031]
Kd 0.0019Binding constant for DDR1 kinase domain [AID624850, Type: Literature]Epithelial discoidin domain-containing receptor 1 [gi:729008]
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20
[SID103320031]
Kd 0.0019Binding constant for DDR1 kinase domain [AID435400, Type: Literature]Epithelial discoidin domain-containing receptor 1 [gi:729008]
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21
[SID103320031]
Kd 0.0029Binding constant for p38-gamma kinase domain [AID624766, Type: Literature]Mitogen-activated protein kinase 12 [gi:2851522]
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22
[SID103320031]
IC50 0.004Inhibition of human recombinant full-length N-terminal GST-tagged p38alpha expressed in Escherichia coli by radiometric kinase assay [AID497107, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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23
[SID103320031]
Kd 0.0046Binding affinity to JNK2 [AID501376, Type: Literature]
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24
[SID103320031]
Kd 0.0056Average Binding Constant for JNK2 ; NA=Not Active at 10 uM [AID256637, Type: Literature]Mitogen-activated protein kinase 9 [gi:85700366]
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25
[SID103320031]
IC50 0.006Inhibition of JNK2a [AID319703, Type: Literature]
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26
[SID103320031]
IC50 0.006Inhibition of Jnk2alpha2 [AID277018, Type: Literature]
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27
[SID103320031]
Ki 0.0064Displacement of rhodamine-green labeled (2-(6-amino-3-imino-3H-xanthen-9-yl)-5-{[({4-[4-(4-Cl-3-hydroxyphenyl)-5-(4-pyridinyl)-1H-imidazol-2yl]phenyl}methyl)amino]carbonyl}benzoic acid from human p38alpha by fluorescence polarization [AID341049, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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28
[SID103320031]
IC50 0.007Inhibition of P38beta2 [AID636480, Type: Literature]
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29
[SID103320031]
Kd 0.0071Average Binding Constant for STK10 ; NA=Not Active at 10 uM [AID256604, Type: Literature]Serine/threonine-protein kinase 10 [gi:12643358]
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30
[SID103320031]
Kd 0.0072Binding constant for p38-beta kinase domain [AID624890, Type: Literature]Mitogen-activated protein kinase 11 [gi:134047835]
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31
[SID103320031]
Kd 0.0073Binding constant for full-length JNK2 [AID435409, Type: Literature]Mitogen-activated protein kinase 9 [gi:85700366]
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32
[SID103320031]
Kd 0.0073Binding constant for JNK2 kinase domain [AID624717, Type: Literature]Mitogen-activated protein kinase 9 [gi:85700366]
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33
[SID103320031]
Kd 0.0075Binding affinity to N-terminus His-tagged human p38alpha expressed in Escherichia coli BL21 DE3 after 5 hrs by fluorescence analysis [AID639971, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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34
[SID103320031]
IC50 0.008Inhibition of N-terminus His-tagged human p38alpha expressed in Escherichia coli BL21 DE3 using GST-tagged ATF2 as substrate after 90 mins by HTRF assay [AID639972, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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35
[SID103320031]
Kd 0.0083Binding constant for TIE1 kinase domain [AID625017, Type: Literature]Tyrosine-protein kinase receptor Tie-1 [gi:549081]
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36
[SID103320031]
Kd 0.0083Binding constant for TIE1 kinase domain [AID435198, Type: Literature]Tyrosine-protein kinase receptor Tie-1 [gi:549081]
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37
[SID103320031]
IC50 0.009Inhibition of MAPK p38 [AID292892, Type: Literature]
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38
[SID103320031]
Kd 0.0099Average Binding Constant for TNIK ; NA=Not Active at 10 uM [AID256566, Type: Literature]TRAF2 and NCK-interacting protein kinase [gi:29840818]
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39
[SID103320031]
IC50 0.01Inhibition of human recombinant P38alpha-mediated ATF2 phosphorylation after 1 hr [AID673366, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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40
[SID103320031]
IC50 0.01Inhibition of JNK2alpha2 [AID636461, Type: Literature]
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41
[SID103320031]
Kd 0.011Average Binding Constant for TEK ; NA=Not Active at 10 uM [AID256617, Type: Literature]Angiopoietin-1 receptor [gi:218511853]
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42
[SID103320031]
Kd 0.012Binding affinity to p38alpha MAP kinase (unknown origin) by FLiK assay [AID721303, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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43
[SID103320031]
Kd 0.012Binding constant for LOK kinase domain [AID625030, Type: Literature]Serine/threonine-protein kinase 10 [gi:12643358]
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44
[SID103320031]
Kd 0.012Binding constant for LOK kinase domain [AID435677, Type: Literature]Serine/threonine-protein kinase 10 [gi:12643358]
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45
[SID103320031]
IC50 0.013Inhibition of LPS-induced TNFalpha production in human THP1 cells [AID322017, Type: Literature]
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46
[SID103320031]
Kd 0.014Average Binding Constant for p38-gamma ; NA=Not Active at 10 uM [AID256615, Type: Literature]Mitogen-activated protein kinase 12 [gi:2851522]
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47
[SID103320031]
IC50 0.015Antiinflammatory activity in LPS-stimulated human isolated PBMC assessed as inhibition of TNFalpha production preincubated for 1 hr prior to LPS-challenge by ELISA [AID639674, Type: Literature]
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48
[SID103320031]
IC50 0.017Inhibition of phospho-p38 alpha activity by ELISA [AID495022, Type: Literature]
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49
[SID103320031]
IC50 0.017Inhibition of human p38-alpha kinase phosphorylation [AID322019, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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50
[SID103320031]
EC50 0.018Inhibition of LPS-induced tumor necrosis factor-alpha (TNF-alpha) production in THP-1 cells [AID209191, Type: Literature]Mitogen-activated protein kinase 14 [gi:2499600]
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