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Canertinib (CID 156414) - Compound BioActivity Data
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BioActivity Outcomes:
Active(346)
 
 
Inactive(198)
 
 
Inconclusive(46)
 
 
Unspecified(542)
 
 
Top Targets:
PKc(98)
 
 
 
 
PKc like(79)
 
 
 
 
STKc AGC(45)
 
 
 
 
PTKc Abl(39)
 
 
 
PTKc EGFR(35)
 
 
BioAssay Types:
Literature(928)
 
 
 
 
Confirmatory(174)
 
 
 
 
Summary(24)
 
 
 
 
Screening(2)
 
 
BioActivity Types:
Kd(879)
 
 
 
 
Potency(103)
 
 
 
 
IC50(27)
 
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1040    Data Row: 1132   Total Pages: 23   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103202250]
Kd 0.0001Binding constant for EGFR(T790M) kinase domain [AID625007, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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2
[SID103202250]
Kd 0.00013Binding constant for EGFR(G719C) kinase domain [AID435157, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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3
[SID103202250]
Kd 0.00013Binding constant for EGFR(G719C) kinase domain [AID624998, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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4
[SID103202250]
Kd 0.00017Binding constant for EGFR(L747-E749del, A750P) kinase domain [AID625000, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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5
[SID103202250]
Kd 0.00017Binding constant for EGFR(L747-E749del, A750P) kinase domain [AID435652, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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6
[SID103202250]
Kd 0.00019Binding constant for EGFR(G719S) kinase domain [AID435402, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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7
[SID103202250]
Kd 0.00019Binding constant for EGFR(S752-I759del) kinase domain [AID435792, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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8
[SID103202250]
Kd 0.00019Binding constant for EGFR kinase domain [AID435156, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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9
[SID103202250]
Kd 0.00019Binding constant for EGFR(S752-I759del) kinase domain [AID625006, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View
10
[SID103202250]
Kd 0.00019Binding constant for EGFR(G719S) kinase domain [AID624999, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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11
[SID103202250]
Kd 0.00019Binding constant for EGFR kinase domain [AID624996, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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12
[SID103202250]
Kd 0.00022Binding constant for EGFR(L861Q) kinase domain [AID625005, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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13
[SID103202250]
Kd 0.00022Binding constant for EGFR(L861Q) kinase domain [AID435907, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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14
[SID103202250]
Kd 0.00024Binding constant for EGFR(L858R) kinase domain [AID435525, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View
15
[SID103202250]
Kd 0.00024Binding constant for EGFR(L858R) kinase domain [AID625003, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View
16
[SID103202250]
Kd 0.00026Binding constant for EGFR(L747-S752del, P753S) kinase domain [AID625001, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View
17
[SID103202250]
Kd 0.00026Binding constant for EGFR(L747-T751del,Sins) kinase domain [AID625002, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View
18
[SID103202250]
Kd 0.00026Binding constant for EGFR(E746-A750del) kinase domain [AID624997, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View
19
[SID103202250]
Kd 0.00026Binding constant for EGFR(L747-T751del,Sins) kinase domain [AID435906, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View
20
[SID103202250]
Kd 0.00026Binding constant for EGFR(E746-A750del) kinase domain [AID435791, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View
21
[SID103202250]
Kd 0.00026Binding constant for EGFR(L747-S752del, P753S) kinase domain [AID435653, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View
22
[SID103202250]
Kd 0.00028Binding constant for EGFR(L858R,T790M) kinase domain [AID625004, Type: Literature]Epidermal growth factor receptor [gi:2811086]
View
23
[SID103202250]
IC50 0.001Antiproliferative activity against human HCC827 cells harboring EGFR del E746-A750 mutant after 72 hrs by MTS assay [AID662596, Type: Literature]
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24
[SID103202250]
Kd 0.0014Average Binding Constant for EGFR ; NA=Not Active at 10 uM [AID256664, Type: Literature]Epidermal growth factor receptor [gi:2811086]
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25
[SID103202250]
IC50 0.0015Inhibition of EGFR [AID719885, Type: Literature]
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26
[SID103202250]
IC50 0.0015Inhibition of phosphorylation of a polyglutamic acid/tyrosine random copolymer by EGFR enzyme prepared from human A431 carcinoma cell vesicles by immunoaffinity chromatography [AID67284, Type: Literature]
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27
[SID103202250]
IC50 0.0023Inhibition of EGFR [AID392129, Type: Literature]
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28
[SID103202250]
IC50 0.005Inhibition of EGFR by HTRF assay [AID410943, Type: Literature]
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29
[SID103202250]
IC50 0.005Inhibition of ErbB2 [AID719887, Type: Literature]
View
30
[SID103202250]
Kd 0.0065Binding constant for ERBB4 kinase domain [AID624815, Type: Literature]Receptor tyrosine-protein kinase erbB-4 [gi:3913590]
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31
[SID103202250]
IC50 0.0074Inhibition of EGF-stimulated autophosphorylation of EGFR enzyme in A431 cells detected by immunoblotting [AID67283, Type: Literature]
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32
[SID103202250]
Kd 0.0084Average Binding Constant for ERBB2 ; NA=Not Active at 10 uM [AID256662, Type: Literature]Receptor tyrosine-protein kinase erbB-2 [gi:119533]
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33
[SID103202250]
IC50 0.009Inhibition of autophosphorylation of ERBB2 receptor kinase in MDA-MB 453 cells [AID68098, Type: Literature]
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34
[SID103202250]
EC50 0.01Antiproliferative activity against human BT474 cells overexpressing ERBb2 after 3 days by methylene blue staining [AID410946, Type: Literature]
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35
[SID103202250]
IC50 0.01Inhibition of ErbB4 [AID719888, Type: Literature]
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36
[SID103202250]
IC50 0.014Inhibition of HER4 [AID392131, Type: Literature]
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37
[SID103202250]
Kd 0.022Binding constant for ABL1(Q252H)-phosphorylated kinase domain [AID624987, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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38
[SID103202250]
Kd 0.029Binding constant for ERBB4 kinase domain [AID435797, Type: Literature]Tubulin alpha-1A chain [gi:55977470]
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39
[SID103202250]
IC50 0.029Inhibition of Blk expressed in mouse BAF3 cells assessed as cytotoxicity [AID392139, Type: Literature]
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40
[SID103202250]
Kd 0.03Binding constant for ABL1-phosphorylated kinase domain [AID624992, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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41
[SID103202250]
Kd 0.03Binding constant for ABL1(E255K)-phosphorylated kinase domain [AID624978, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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42
[SID103202250]
Kd 0.038Binding constant for ABL1(M351T)-phosphorylated kinase domain [AID624985, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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43
[SID103202250]
Kd 0.042Binding constant for ABL1(Y253F)-phosphorylated kinase domain [AID624990, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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44
[SID103202250]
Kd 0.044Average Binding Constant for GAK ; NA=Not Active at 10 uM [AID256612, Type: Literature]Cyclin-G-associated kinase [gi:17375734]
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45
[SID103202250]
Kd 0.045Binding constant for BLK kinase domain [AID624841, Type: Literature]Tyrosine-protein kinase Blk [gi:158936749]
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46
[SID103202250]
Kd 0.045Binding constant for BLK kinase domain [AID435646, Type: Literature]Tyrosine-protein kinase Blk [gi:158936749]
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47
[SID103202250]
Kd 0.046Binding constant for ABL1(H396P)-nonphosphorylated kinase domain [AID624983, Type: Literature]Tyrosine-protein kinase ABL1 [gi:85681908]
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48
[SID103202250]
IC50 0.048Inhibition of HER2 [AID392130, Type: Literature]
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49
[SID103202250]
IC50 0.05Inhibition of Blk [AID392133, Type: Literature]
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50
[SID103202250]
EC50 0.05Antiproliferative activity against human HN5 cells overexpressing EGFR after 3 days by methylene blue staining [AID410945, Type: Literature]
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