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3,6-diamino-10-methylacridinium (CID 15558347) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(104)
 
 
Inactive(246)
 
 
Inconclusive(27)
 
 
Unspecified(7)
 
 
Top Targets:
7TM GPCR Srsx(12)
 
 
 
 
7TM GPCR Srx(12)
 
 
 
Troponin(6)
 
 
 
PP1c bdg(6)
 
 
 
 
ABCC CFTR1(5)
 
 
 
BioAssay Types:
Screening(244)
 
 
 
 
Confirmatory(115)
 
 
 
 
 
Literature(4)
 
 
 
BioActivity Types:
Potency(79)
 
 
 
 
 
IC50(20)
 
 
 
 
AC50(4)
 
 
EC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 341    Data Row: 384   Total Pages: 8   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID93576780]
AbsAC35_uM 0.0327Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (3D7 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-05_Inhibitor_Dose_CherryPick_Activity [AID652047, Type: confirmatory]
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2
[SID93576780]
AbsAC35_uM 0.0524Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (HB3 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-06_Inhibitor_Dose_CherryPick_Activity [AID652041, Type: confirmatory]
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3
[SID93576780]
AC50_uM 0.285C-LANA FP assay Measured in Biochemical System Using Plate Reader - 2117-01_Inhibitor_Dose_CherryPick_Activity [AID504725, Type: confirmatory]LANA [Human herpesvirus 8] [gi:312275222]
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4
[SID93576780]
AbsAC40_uM 0.297High Content Cell-Based Imaging Primary HTS to Identify Small Molecules Involved in X-Chromosome Reactivation and Reprogramming Measured in Cell-Based System Using Imaging - 7015-01_Activator_Dose_CherryPick_Activity [AID743394, Type: confirmatory]
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5
[SID93576780]
Potency 0.3359qHTS for Inhibitors of PLK1-PDB (polo-like kinase 1 - polo-box domain): Primary Screen [AID720504, Type: confirmatory]serine/threonine-protein kinase PLK1 [Homo sapiens] [gi:21359873]
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6
[SID93576780]
AbsAC35_uM 0.51Identification of Small Molecule Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Delta508 Mutation Function in Fischer Rat Thyroid (FRT) Cells. Measured in Cell-Based System Using Plate Reader - 7017-02_Other_Dose_CherryPick_Activity [AID743402, Type: confirmatory]
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7
[SID93576780]
AbsAC40_uM 0.522High Content Cell-Based Imaging Primary HTS to Identify autofluorescent compounds using cells not inducing Measured in Cell-Based System Using Imaging - 7015-02_Activator_Dose_CherryPick_Activity [AID743396, Type: confirmatory]
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8
[SID93576780]
IC50 0.945Fluorescence-based biochemical high throughput screening dose response assay to identify inhibitors of Crimean-Congo Hemorrhagic Fever (CCHF) viral ovarian tumor domain protease (vOTU): Pep-AMC substrate [AID720578, Type: confirmatory]putative polyprotein [Crimean-Congo hemorrhagic fever virus] [gi:76364066]
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9
[SID93576780]
Potency 1.1582qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID93576780]
AbsAC35_uM 1.17HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Other_Dose_CherryPick_Activity_Set2 [AID743395, Type: confirmatory]
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11
[SID93576780]
AC50_uM 1.661C-LANA Counter Screen: DNA intercalators Measured in Biochemical System Using Plate Reader - 2117-02_Inhibitor_Dose_CherryPick_Activity_Set2 [AID504727, Type: confirmatory]LANA [Human herpesvirus 8] [gi:312275222]
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12
[SID93576780]
AbsAC1000_uM 1.824In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_Dose_CherryPick_Activity [AID540271, Type: confirmatory]HSP40, subfamily A, putative [Plasmodium falciparum 3D7] [gi:124809271]
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13
[SID93576780]
Potency 2.0596qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID93576780]
Potency 3.1623qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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15
[SID93576780]
Potency 3.1623qHTS for Inhibitors of Polymerase Iota [AID588590, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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16
[SID93576780]
Potency 3.2643qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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17
[SID93576780]
AC50_uM 3.52Identification of Small Molecule Correctors of the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Delta508 Mutation Function in Human Bronchial Epithelial Cells. Measured in Cell-Based System Using Plate Reader - 7017-01_Other_Dose_CherryPick_Activity [AID743267, Type: confirmatory]cystic fibrosis transmembrane conductance regulator ATP-binding cassette sub-family C member 7 [Homo sapiens] [gi:89348172]
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18
[SID93576780]
Potency 3.6626Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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19
[SID93576780]
Potency 3.9811Inhibitors of USP1/UAF1: Primary Screen [AID743255, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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20
[SID93576780]
Potency 5.1735qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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21
[SID93576780]
IC50 5.39Counterscreen for inhibitors of Crimean-Congo Hemorrhagic Fever (CCHF) viral ovarian tumor domain protease (vOTU): Pep-AMC substrate: Fluorescence-based biochemical high throughput screening assay to identify inhibitors of Crimean-Congo Hemorrhagic Fever (CCHF) viral ovarian tumor domain protease (vOTU): Ub-AMC substrate [AID720577, Type: confirmatory]putative polyprotein [Crimean-Congo hemorrhagic fever virus] [gi:76364066]
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22
[SID93576780]
Potency 5.6234qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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23
[SID93576780]
AC50_uM 7.94224 hour HeLa Cytotox assay Measured in Cell-Based System Using Plate Reader - 2117-03_Inhibitor_Dose_CherryPick_Activity [AID504726, Type: confirmatory]LANA [Human herpesvirus 8] [gi:312275222]
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24
[SID93576780]
Potency 10.6213qHTS for Inhibitors of Polymerase Kappa: Confirmatory Assay for Cherry-picked Compounds [AID720501, Type: Literature]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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25
[SID93576780]
CC50 11.15Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - HeLa Cytotoxicity [AID624300, Type: confirmatory]
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26
[SID93576780]
Potency 15.003qHTS for Inhibitors of Polymerase Iota: Confirmatory Assay for Cherry-picked Compounds [AID720496, Type: confirmatory]DNA polymerase iota [Homo sapiens] [gi:154350220]
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27
[SID93576780]
Potency 15.8489qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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28
[SID93576780]
Potency 19.1821qHTS for Inhibitors of WRN Helicase: Confirmatory Assay for Cherry-picked Compounds. [AID720497, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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29
[SID93576780]
Potency 19.1821qHTS for Inhibitors of WRN Helicase: BLM Helicase Counterscreen for WRN Inhibitors [AID720503, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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30
[SID93576780]
Potency 22.3872qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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31
[SID93576780]
Potency 35.4813qHTS for Inhibitors of Polymerase Eta [AID588591, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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32
[SID93576780]
Potency 35.4813qHTS for Small Molecule Inhibitors of the ERG Ets/DNA interaction [AID624246, Type: confirmatory]transcriptional regulator ERG isoform 3 [Homo sapiens] [gi:343478176]
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33
[SID93576780]
Potency 37.933qHTS for Inhibitors of Polymerase Eta: Confirmatory Assay for Cherry-picked Compounds [AID720502, Type: confirmatory]DNA polymerase eta [Homo sapiens] [gi:5729982]
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34
[SID93576780]
Potency 63.0957qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 3 (EPAC1): primary screen [AID720707, Type: confirmatory]Rap guanine nucleotide exchange factor 3 [gi:317373593]
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35
[SID93576780]
IC50 97.47Discovery of small molecule inhibitors of the oncogenic and cytokinetic protein MgcRacGAP - Primary and Confirmatory Screens [AID624330, Type: confirmatory]rac GTPase-activating protein 1 [Homo sapiens] [gi:21361397]
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36
[SID93576780]
Potency 100qHTS for Agonist of cAMP-regulated guanine nucleotide exchange factor 4 (EPAC2): primary screen [AID720711, Type: confirmatory]Rap guanine nucleotide exchange factor 4 [gi:32171491]
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37
[SID93576780]
uHTS identification of agonists of the CRF-binding protein and CRF-R2 receptor complex [AID588473, Type: screening]corticotropin-releasing hormone receptor 2 [Homo sapiens] [gi:38349113]
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38
[SID93576780]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human cholinergic receptor, muscarinic 1 (CHRM1) [AID588814, Type: screening]muscarinic acetylcholine receptor M1 [Homo sapiens] [gi:37622910]
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39
[SID93576780]
Epi Absorbance-based biochemical primary high throughput screening assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2) [AID720702, Type: screening]tyrosyl-DNA phosphodiesterase 2 [Homo sapiens] [gi:23510348]
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40
[SID93576780]
Fluorescence polarization-based biochemical high throughput confirmation assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID687036, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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41
[SID93576780]
Primary biochemical fluorescence polarization-based high throughput screening assay to identify inhibitors of protein arginine methyltransferase 1 (PRMT1) [AID652257, Type: screening]PRMT1 protein [Homo sapiens] [gi:32425330]
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42
[SID93576780]
Epi Absorbance-based biochemical high throughput confirmation assay to identify inhibitors of human tyrosyl-DNA phosphodiesterase 2 (TDP2) [AID743263, Type: screening]tyrosyl-DNA phosphodiesterase 2 [Homo sapiens] [gi:23510348]
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43
[SID93576780]
uHTS identification of small molecule inhibitors of Plasmodium falciparum Glucose-6-phosphate dehydrogenase via a fluorescence intensity assay [AID504690, Type: screening]glucose-6-phosphate dehydrogenase-6-phosphogluconolactonase [Plasmodium berghei] [gi:12381848]
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44
[SID93576780]
uHTS identification of inhibitors of NadD in a Colorimetric assay [AID602399, Type: screening]hypothetical protein SA1422 [Staphylococcus aureus subsp. aureus N315] [gi:15927174]
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45
[SID93576780]
qHTS for Agonists of the Human Mucolipin Transient Receptor Potential 1 (TRPML1) [AID624414, Type: screening]mucolipin-1 [Homo sapiens] [gi:10092597]
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46
[SID93576780]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
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47
[SID93576780]
Counterscreen for inverse agonists of the liver receptor homolog-1 (LRH-1; NR5A2): Luminescence-based cell-based high throughput assay to identify inverse agonists of the Steroidogenic Factor 1 Nuclear Receptor (SF1; NR5A1) [AID651614, Type: screening]steroidogenic factor 1 [Homo sapiens] [gi:20070193]
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48
[SID93576780]
Fluorescence-based cell-based primary high throughput confirmation assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) [AID651783, Type: screening]trace amine-associated receptor 1 [Homo sapiens] [gi:21264324]
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49
[SID93576780]
Fluorescence-based cell-based primary high throughput screening assay to identify agonists of the human trace amine associated receptor 1 (TAAR1) [AID624467, Type: screening]trace amine-associated receptor 1 [Homo sapiens] [gi:21264324]
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50
[SID93576780]
Fluorescence Intensity-based biochemical primary high throughput confirmation assay to identify activators of kallikrein-7 (K7) zymogen [AID686949, Type: screening]kallikrein-7 isoform 1 preproprotein [Homo sapiens] [gi:21327705]
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