Capsaicin (CID 1548943) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(47)
 
 
Inactive(772)
 
 
Inconclusive(68)
 
 
Unspecified(174)
 
 
Top Targets:
7TM GPCR Srx(27)
 
 
 
ANK(27)
 
 
 
 
7TM GPCR Srsx(17)
 
 
 
NR LBD TR(16)
 
 
p450(11)
 
 
 
 
BioAssay Types:
Confirmatory(424)
 
 
 
 
 
Screening(288)
 
 
 
Literature(134)
 
 
 
 
 
BioActivity Types:
Potency(366)
 
 
 
 
 
IC50(130)
 
 
 
 
EC50(16)
 
 
Ki(9)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 797    Data Row: 1061   Total Pages: 22   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103248360]
EC50 0.0039Agonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry [AID644962, Type: Literature]Transient receptor potential cation channel subfamily V member 1 [gi:296452849]
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2
[SID103248360]
EC50 0.0039Agonist activity at human TRPV1 ion channel expressed in HEK293 cells assessed as calcium influx by fluo-4-Am-based fluorimetry [AID644962, Type: Literature]Transient receptor potential cation channel subfamily V member 1 [gi:296452849]
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3
[SID103248360]
Ki 0.006Binding affinity to human recombinant TRPV1 [AID538418, Type: Literature]Transient receptor potential cation channel subfamily V member 1 [gi:296452849]
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4
[SID103248360]
Ki 0.006Binding affinity to human recombinant TRPV1 [AID538418, Type: Literature]Transient receptor potential cation channel subfamily V member 1 [gi:296452849]
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5
[SID103248360]
IC50 0.019Binding affinity to rat TRPV1 [AID538419, Type: Literature]Transient receptor potential cation channel subfamily V member 1 [gi:71164787]
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6
[SID103248360]
EC50 0.02Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level [AID353804, Type: Literature]Transient receptor potential cation channel subfamily V member 1 [gi:296452849]
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7
[SID103248360]
EC50 0.02Agonist activity at human recombinant TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level [AID353804, Type: Literature]Transient receptor potential cation channel subfamily V member 1 [gi:296452849]
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8
[SID103248360]
EC50 0.03In vitro agonist activity, increased [Ca2+] influx, at vanilloid receptor of rat dorsal root ganglia [AID218163, Type: Literature]Transient receptor potential cation channel subfamily V member 4 [gi:62901120]
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9
[SID103248360]
EC50 0.04Agonist activity at human recombinant TRPV1 expressed in human HEK293 cells [AID292699, Type: Literature]Transient receptor potential cation channel subfamily V member 1 [gi:296452849]
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10
[SID103248360]
EC50 0.04Agonist activity at human recombinant TRPV1 expressed in human HEK293 cells [AID292699, Type: Literature]Transient receptor potential cation channel subfamily V member 1 [gi:296452849]
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11
[SID103248360]
EC50 0.04Agonist activity at human TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level [AID452447, Type: Literature]Transient receptor potential cation channel subfamily V member 1 [gi:296452849]
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12
[SID103248360]
EC50 0.04Agonist activity at human TRPV1 expressed in HEK293 cells assessed as increase in intracellular calcium level [AID452447, Type: Literature]Transient receptor potential cation channel subfamily V member 1 [gi:296452849]
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13
[SID103248360]
EC50 0.0448In vitro [Ca2+] influx relative to capsaicin by Rat Vanilloid receptor (VR1) expressing CHO cells [AID218314, Type: Literature]Transient receptor potential cation channel subfamily V member 1 [gi:71164787]
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14
[SID103248360]
EC50 0.0448Agonist activity at rat TRPV1 receptor expressed in CHO cells assessed as calcium uptake [AID345832, Type: Literature]Transient receptor potential cation channel subfamily V member 1 [gi:71164787]
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15
[SID124890089]
Potency 0.0912qHTS Assay for Compounds that Act as Agonists of the Vanilloid Receptor 1: Hit Validation in Parental Cell Line Calcium Assay [AID623960, Type: confirmatory]TRPV1 gene product [Homo sapiens] [gi:74315350]
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16
[SID124890089]
Potency 0.0912qHTS Assay for Compounds that Act as Agonists of the Vanilloid Receptor 1: Hit Validation in Parental Cell Line Calcium Assay [AID623960, Type: confirmatory]TRPV1 gene product [Homo sapiens] [gi:74315350]
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17
[SID103248360]
EC50 0.26In vitro effective dose for contraction of guinea pig ileum [AID73731, Type: Literature]
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18
[SID103248360]
EC50 0.26Effective concentration for guinea pig ileum contraction in an in vitro assay [AID73732, Type: Literature]
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19
[SID103248360]
EC50 0.26In vitro contraction in guinea pig ileum equivalent to 50% capsaicin response [AID73895, Type: Literature]
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20
[SID103248360]
EC50 0.3Compound tested in vitro for [Ca2+] influx into neonatal rat dorsal root ganglia (DRG) [AID175476, Type: Literature]
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21
[SID103248360]
EC50 0.3In vitro agonist activity against [Ca2+] uptake in neonatal rat cultured spinal sensory neurons [AID175840, Type: Literature]
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22
[SID103248360]
EC50 0.3In vitro effective concentration for [Ca2+] uptake and accumulation of [Ca2+] in neonatal rat cultured spinal sensory neurons [AID175843, Type: Literature]
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23
[SID103248360]
EC50 0.3In vitro effective concentration for [Ca2+] uptake into dorsal root ganglia neurones in culture [AID175848, Type: Literature]
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24
[SID103248360]
EC50 0.3Increased [Ca2+] influx into Dorsal Root Ganglion(DRG) neurons [AID65831, Type: Literature]
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25
[SID103248360]
EC50 0.3Effective concentration for [Ca2+] uptake into dorsal root ganglia neurones in rat cultured spinal sensory neurones [AID175668, Type: Literature]Transient receptor potential cation channel subfamily V member 4 [gi:62901120]
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26
[SID103248360]
IC50 1.551DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) [AID625243, Type: other]Prostaglandin G/H synthase 1 [gi:317373262]
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27
[SID103248360]
Ki 1.7In vitro binding to Rat Vanilloid receptor 1 (VR1) expressing CHO cells compared to capsacin [AID218326, Type: Literature]Transient receptor potential cation channel subfamily V member 1 [gi:71164787]
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28
[SID103248360]
Ki 1.8In vitro binding affinity towards Rat Vanilloid receptor 1 (VR1) by [3H]RTX displacement. [AID218324, Type: Literature]
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29
[SID103248360]
Ki 1.808Displacement of [3H]RTX form rat TRPV1 receptor expressed in CHO/VR1 cell system [AID348212, Type: Literature]Transient receptor potential cation channel subfamily V member 1 [gi:71164787]
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30
[SID50105473]
Potency 1.9953qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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31
[SID50105473]
Potency 1.9953qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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32
[SID103248360]
Ki 2Binding affinity against Vanilloid receptor in dorsal Root Ganglion (DRG) membranes using [3H]RTX binding assay. [AID218307, Type: Literature]
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33
[SID103248360]
Ki 2Displacement of [3H]RTX from Vanilloid receptor in Rat spinal cord membranes [AID218309, Type: Literature]Transient receptor potential cation channel subfamily V member 1 [gi:71164787]
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34
[SID17389996]
Potency 2.5119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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35
[SID17389996]
Potency 2.5119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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36
[SID17389996]
Potency 2.5119qHTS Assay for Inhibitors and Substrates of Cytochrome P450 3A4 [AID884, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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37
[SID103248360]
IC50 3DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625245, Type: other]Cytochrome P450 1A2 [gi:117144]
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38
[SID103248360]
IC50 3DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625245, Type: other]Cytochrome P450 1A2 [gi:117144]
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39
[SID103248360]
IC50 3DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625245, Type: other]Cytochrome P450 1A2 [gi:117144]
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40
[SID103248360]
IC50 3.8Inhibition of COX1 [AID403341, Type: Literature]
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41
[SID124883049]
Potency 8.9125qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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42
[SID124883049]
Potency 8.9125qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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43
[SID124883049]
Potency 8.9125qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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44
[SID104171351]
Potency 9.0743S16 Schwann cell PMP22 intronic element firefly luciferase assay [AID624032, Type: confirmatory]Pmp22 gene product [Rattus norvegicus] [gi:8393992]
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45
[SID124883049]
Potency 11.2202qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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46
[SID124883049]
Potency 11.2202qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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47
[SID124883049]
Potency 11.2202qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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48
[SID26752819]
Potency 15.8489qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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49
[SID26752819]
Potency 15.8489qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
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50
[SID124883047]
Potency 29.8554qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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