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Digoxigenin (CID 15478) - Compound BioActivity Data
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BioActivity Outcomes:
Active(72)
 
 
Inactive(430)
 
 
Inconclusive(11)
 
 
Unspecified(9)
 
 
Top Targets:
7TM GPCR Srx(21)
 
 
 
Death TRAILR..(12)
 
 
 
 
7TM GPCR Srsx(12)
 
 
 
B zip1(5)
 
 
 
ANK(5)
 
 
 
BioAssay Types:
Screening(363)
 
 
 
 
Confirmatory(134)
 
 
 
 
 
Literature(16)
 
 
 
BioActivity Types:
Potency(100)
 
 
 
 
 
IC50(16)
 
 
 
AC50(7)
 
 
 
 
Kd(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 468    Data Row: 522   Total Pages: 27   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID46392439]
Kd 0.0302Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Engineered Lipocalin Diga16 In Complex With Digoxigenin [gi:33357289]
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2
[SID46392439]
Kd 0.0302Experimentally measured binding affinity data (Kd) for protein-ligand complexes derived from PDB [AID977611, Type: Literature]Chain A, Engineered Lipocalin Diga16 In Complex With Digoxigenin [gi:33357289]
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3
[SID56463065]
IC50 0.05A Cell-Based Confirmatory Screen for Compounds that Inhibit VEEV, TC-83 [AID588727, Type: confirmatory]
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4
[SID56463065]
AbsAC35_uM 0.373HepG2 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-02_Inhibitor_Dose_CherryPick_Activity_Set3 [AID720589, Type: confirmatory]
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5
[SID56463065]
Potency 0.4611Nrf2 qHTS screen for inhibitors: Nrf2 A549 ARE-Fluc Confirmation Assay for Hit Validation [AID720524, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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6
[SID56463065]
Potency 0.4611Nrf2 qHTS screen for inhibitors [AID504444, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 2 [Homo sapiens] [gi:224028257]
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7
[SID56463065]
Potency 0.5623qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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8
[SID56463065]
IC50_Mean 0.58Dose response counterscreen of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a HEK-293T cell line using a luminescence assay [AID489041, Type: confirmatory]
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9
[SID56463065]
AC50_uM 0.654Dose Response HTS Screen to Identify Cytotoxic Compounds of HMLE_sh_eGFP [AID463074, Type: confirmatory]
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10
[SID56463065]
Potency 0.8199qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-IDH1KD cell line [AID686971, Type: confirmatory]
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11
[SID56463065]
AbsAC35_uM 1Luminescence Cell-Based Primary HTS to identify inhibitors of the oncoprotein EWS/Fli transcriptional activity Measured in Cell-Based System Using Plate Reader - 7014-01_Inhibitor_Dose_CherryPick_Activity [AID686920, Type: confirmatory]
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12
[SID56463065]
AbsAC35_uM 1.1Luminescence cell-based Retest at Dose assay to determine EWS/Fli1 dependent A673 mammalian cell cytotoxity Measured in Cell-Based System Using Plate Reader - 7014-03_Inhibitor_Dose_CherryPick_Activity [AID720587, Type: confirmatory]
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13
[SID56463065]
Potency 1.122qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: mCherry Reporter Primary qHTS [AID720579, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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14
[SID56463065]
Potency 1.122qHTS for Stage-Specific Inhibitors of Vaccinia Orthopoxvirus: Venus Reporter Primary qHTS [AID720580, Type: confirmatory]67.9K protein [Vaccinia virus] [gi:222762]
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15
[SID56463065]
AC50_uM 1.157Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Cancer Stem Cells [AID449748, Type: confirmatory]
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16
[SID56463065]
AbsAC35_uM 1.16HEK293 Cytotoxicity Assay Measured in Cell-Based System Using Plate Reader - 7071-01_Inhibitor_Dose_CherryPick_Activity_Set3 [AID720588, Type: confirmatory]
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17
[SID56463065]
IC50_Mean 1.6Dose Response selectivity of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a 697B cell line using a luminescence assay [AID489033, Type: confirmatory]
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18
[SID56463065]
Potency 2.0596qHTS for induction of synthetic lethality in tumor cells producing 2HG: qHTS for the HT-1080-NT fibrosarcoma cell line [AID686970, Type: confirmatory]IDH1 [Homo sapiens] [gi:49168486]
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19
[SID56463065]
CC50 2.1Vero 76 Cytoxicity Assay for VEEV Compounds [AID588719, Type: confirmatory]
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20
[SID56463065]
AC50_uM 2.35HTS for PAX8 inhibitors using PAX8 luciferase reporter gene assay in RMG-I cells Measured in Cell-Based System Using Plate Reader - 7054-01_Inhibitor_Dose_CherryPick_Activity [AID687027, Type: confirmatory]PAX8 [Homo sapiens] [gi:998701]
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