Idazoxan (CID 154494) - BioAssay Data Summary for Compound
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BioActivity Outcomes:
Active(21)
 
 
Top Targets:
Geminin(2)
 
 
7TM GPCR Srsx(1)
 
 
7TM GPCR Srx(1)
 
 
Aldo ket red(1)
 
 
SWIB(1)
 
 
BioAssay Types:
Literature(9)
 
 
Confirmatory(9)
 
 
Screening(2)
 
 
BioActivity Types:
Potency(9)
 
 
IC50(5)
 
 
Kd(4)
 
 
SAR
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 21    Data Row: 21   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103674322]
Kd 0.01047Alpha-2 adrenergic receptor agonist activity in mouse vas deferens assay compared to clonidine [AID36495, Type: Literature]Alpha-2A adrenergic receptor [gi:231460]
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2
[SID103674322]
Kd 0.01585Antagonistic activity against Alpha-2 adrenergic receptor in the prostatic portion of the rat vas deferens [AID35359, Type: Literature]
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3
[SID103674322]
Kd 0.50119Alpha-1 adrenergic receptor agonist activity in rat anococcygeus assay [AID36173, Type: Literature]Alpha-1B adrenergic receptor [gi:543734]
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4
[SID103674322]
Kd 0.50119Alpha-1 adrenergic receptor agonist activity in rat anococcygeus assay [AID36173, Type: Literature]Alpha-1B adrenergic receptor [gi:543734]
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5
[SID103674322]
Kd 1.58489Agonistic activity against aAlpha-1 adrenergic receptor in the epidermal portion of the rat vas deferens; Compound contracture of vas at conc. grater than 10E-6 [AID35718, Type: Literature]
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6
[SID50106461]
Potency 7.9433Validation screen for small molecules that induce DNA re-replication in MCF 10A normal breast cells [AID463097, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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7
[SID50106461]
Potency 8.9125qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
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8
[SID103674322]
IC50 10Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
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9
[SID103674322]
IC50 10Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
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10
[SID103674322]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
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11
[SID103674322]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
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12
[SID103674322]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
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13
[SID50106461]
Potency 12.5893qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
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14
[SID56422421]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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15
[SID56422421]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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16
[SID56422421]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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17
[SID56422421]
Potency 18.3564A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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18
[SID50106461]
Potency 19.9526Validation screen for inhibitors of Lassa infection [AID463096, Type: confirmatory]
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19
[SID50106461]
Potency 19.9526qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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20
[SID56422421]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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21
[SID56422421]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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22
[SID56422421]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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23
[SID50106461]
Potency 28.1838qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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24
[SID855744]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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25
[SID855744]
 Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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26
[SID855744]
 uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
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27
[SID855744]
 Voltage-Dependent Potassium Channel Beta Subunit (KvBeta) Negative Modulator Primary Screen [AID622, Type: screening]RCKbeta2 [Rattus norvegicus] [gi:499328]
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