Bookmark and Share
Idazoxan (CID 154494) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(27)
 
 
Inactive(898)
 
 
Inconclusive(40)
 
 
Unspecified(6)
 
 
Top Targets:
7TM GPCR Srx(29)
 
 
 
7TM GPCR Srsx(23)
 
 
 
 
alkPPc(14)
 
 
Bcl-2 like(12)
 
 
Tryp SPc(12)
 
 
 
BioAssay Types:
Screening(612)
 
 
 
 
 
Confirmatory(299)
 
 
 
 
 
Literature(30)
 
 
 
 
 
Summary(1)
 
 
BioActivity Types:
Potency(225)
 
 
 
 
 
IC50(50)
 
 
 
EC50(11)
 
 
Kd(8)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 844    Data Row: 971   Total Pages: 20   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103674322]
Kd 0.01047Alpha-2 adrenergic receptor agonist activity in mouse vas deferens assay compared to clonidine [AID36495, Type: Literature]Alpha-2A adrenergic receptor [gi:231460]
View
2
[SID103674322]
Kd 0.01047Alpha-2 adrenergic receptor agonist activity in mouse vas deferens assay compared to clonidine [AID36495, Type: Literature]Alpha-2C adrenergic receptor [gi:231463]
View
3
[SID103674322]
Kd 0.01047Alpha-2 adrenergic receptor agonist activity in mouse vas deferens assay compared to clonidine [AID36495, Type: Literature]Alpha-2B adrenergic receptor [gi:68067981]
View
4
[SID103674322]
Kd 0.01585Antagonistic activity against Alpha-2 adrenergic receptor in the prostatic portion of the rat vas deferens [AID35359, Type: Literature]
View
5
[SID103674322]
Kd 0.50119Alpha-1 adrenergic receptor agonist activity in rat anococcygeus assay [AID36173, Type: Literature]Alpha-1B adrenergic receptor [gi:543734]
View
6
[SID103674322]
Kd 0.50119Alpha-1 adrenergic receptor agonist activity in rat anococcygeus assay [AID36173, Type: Literature]Alpha-1D adrenergic receptor [gi:1168244]
View
7
[SID103674322]
Kd 0.50119Alpha-1 adrenergic receptor agonist activity in rat anococcygeus assay [AID36173, Type: Literature]Alpha-1A adrenergic receptor [gi:1168247]
View
8
[SID103674322]
Kd 1.58489Agonistic activity against aAlpha-1 adrenergic receptor in the epidermal portion of the rat vas deferens; Compound contracture of vas at conc. grater than 10E-6 [AID35718, Type: Literature]
View
9
[SID50106461]
Potency 7.9433Validation screen for small molecules that induce DNA re-replication in MCF 10A normal breast cells [AID463097, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
View
10
[SID50106461]
Potency 8.9125qHTS for differential inhibitors of proliferation of Plasmodium falciparum line 7G8 [AID1815, Type: confirmatory]
View
11
[SID103674322]
IC50 10Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay [AID524791, Type: Literature]
View
12
[SID103674322]
IC50 10Antiplasmodial activity against Plasmodium falciparum HB3 after 72 hrs by SYBR green assay [AID524795, Type: Literature]
View
13
[SID103674322]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay [AID524796, Type: Literature]
View
14
[SID103674322]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay [AID524794, Type: Literature]
View
15
[SID103674322]
IC50 12.5892Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay [AID524790, Type: Literature]
View
16
[SID50106461]
Potency 12.5893qHTS for differential inhibitors of proliferation of Plasmodium falciparum line W2 [AID1883, Type: confirmatory]
View
17
[SID56422421]
Potency 12.9953qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
18
[SID56422421]
Potency 18.3564A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
View
19
[SID50106461]
Potency 19.9526Validation screen for inhibitors of Lassa infection [AID463096, Type: confirmatory]
View
20
[SID50106461]
Potency 19.9526qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
View
21
[SID56422421]
Potency 23.1093qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
View
22
[SID50106461]
Potency 28.1838qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
View
23
[SID855744]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]protein Mdm4 isoform 1 [Homo sapiens] [gi:88702791]
View
24
[SID855744]
uHTS for identification of Inhibitors of Mdm2/MdmX interaction in luminescent format. [AID485346, Type: screening]E3 ubiquitin-protein ligase Mdm2 isoform a [Homo sapiens] [gi:89993689]
View
25
[SID855744]
Voltage-Dependent Potassium Channel Beta Subunit (KvBeta) Negative Modulator Primary Screen [AID622, Type: screening]RCKbeta2 [Rattus norvegicus] [gi:499328]
View
26
[SID855744]
Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
View
27
[SID56422421]
qHTS for Inhibitors of Inflammasome Signaling: IL-1-beta AlphaLISA Primary Screen [AID743279, Type: screening]interleukin-1 beta proprotein [Homo sapiens] [gi:10835145]
View
28
[SID103674322]
Selectivity between alpha2 and alpha-1 adrenoceptors. [AID232492, Type: Literature]
View
29
[SID103674322]
Selectivity ratio is the ratio between pA2 values of alfa2 and alfa1 adrenoceptors [AID233434, Type: Literature]
View
30
[SID855744]
Multiplex HTS Screen of TOR pathway GFP-fusion proteins in Saccharomyes cerevisiae_specifically_CIT2 [AID1870, Type: screening]citrate synthase 2, partial [Saccharomyces cerevisiae] [gi:171229]
View
31
[SID56422421]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
View
32
[SID103674322]
Tested for the 1-Octanol distribution coefficient determined by HPLC method (pH 7.4) [AID26282, Type: Literature]
View
33
[SID50106461]
Potency qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding [AID2675, Type: confirmatory]muscleblind-like protein 1 isoform a [Homo sapiens] [gi:41281591]
View
34
[SID56422421]
Potency 12.5893qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
View
35
[SID56422421]
Potency 14.1254qHTS for Inhibitors of AMA1-RON; Towards Development of Antimalarial Drug Lead: Primary Screen [AID720542, Type: confirmatory]apical membrane antigen 1, AMA1 [Plasmodium falciparum 3D7] [gi:23496270]
View
36
[SID50106461]
Potency 50.1187qHTS Validation Assay for Inhibitors for MPP8 Chromodomain Interactions with Methylated Histone Tails [AID488949, Type: confirmatory]M-phase phosphoprotein 8 [Homo sapiens] [gi:41055989]
View
37
[SID56422421]
Potency 89.1251qHTS of PTHR Inhibitors: Primary Screen [AID743266, Type: confirmatory]parathyroid hormone/parathyroid hormone-related peptide receptor precursor [Homo sapiens] [gi:296080761]
View
38
[SID56422421]
Potency 100HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails [AID540317, Type: confirmatory]chromobox protein homolog 1 [Homo sapiens] [gi:187960037]
View
39
[SID56422421]
Identification of agents that induce E-selectin on human endothelial cells Measured in Cell-Based System Using Imaging - 2152-01_Activator_SinglePoint_HTS_Activity [AID686992, Type: screening]E-selectin precursor [Homo sapiens] [gi:187960042]
View
40
[SID855744]
Potency qHTS Assay for Inhibitors of Ubiquitin-specific Protease USP2a Using CHOP2 as the Reporter [AID463254, Type: confirmatory]ubiquitin carboxyl-terminal hydrolase 2 isoform a [Homo sapiens] [gi:188528692]
View
41
[SID855744]
Potency VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
View
42
[SID855744]
Potency qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
View
43
[SID50106461]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
View
44
[SID50106461]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
View
45
[SID855744]
Potency Total Fluorescence Counterscreen for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1479, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
View
46
[SID855744]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
View
47
[SID56422421]
Fluorescence-based cell-based primary high throughput screening assay to identify inhibitors of TLR9-MyD88 binding. [AID504734, Type: screening]toll-like receptor 9 [Homo sapiens] [gi:194068499]
View
48
[SID50106461]
Potency qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
View
49
[SID855744]
Potency qHTS Assay for Inhibitors of Influenza NS1 Protein Function [AID2326, Type: confirmatory]nonstructural protein 1 [Influenza A virus (A/WSN/1933(H1N1))] [gi:194352380]
View
50
[SID855744]
Primary cell-based high-throughput screening for identification of compounds that activate MrgX1 receptor signaling [AID588627, Type: screening]MAS-related GPR member X1 [Homo sapiens] [gi:195969650]
View