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ruboxistaurin (CID 153999) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(263)
 
 
Inactive(151)
 
 
Inconclusive(1)
 
 
Unspecified(650)
 
 
Top Targets:
PKc(106)
 
 
 
 
PKc like(104)
 
 
 
 
STKc AGC(50)
 
 
 
 
PTKc Abl(32)
 
 
 
PTKc EGFR(23)
 
 
 
 
BioAssay Types:
Literature(992)
 
 
 
 
 
Confirmatory(66)
 
 
 
Screening(1)
 
 
BioActivity Types:
Kd(881)
 
 
 
 
IC50(31)
 
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 988    Data Row: 1065   Total Pages: 22   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103298456]
Kd 0.0025Binding constant for PRKCQ kinase domain [AID625051, Type: Literature]Protein kinase C theta type [gi:20141582]
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2
[SID103298456]
Kd 0.0025Binding constant for PRKCQ kinase domain [AID435321, Type: Literature]Protein kinase C theta type [gi:20141582]
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3
[SID103298456]
Kd 0.0036Binding constant for PRKCD kinase domain [AID435553, Type: Literature]Protein kinase C delta type [gi:205371776]
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4
[SID103298456]
Kd 0.0036Binding constant for PRKCD kinase domain [AID625048, Type: Literature]Protein kinase C delta type [gi:205371776]
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5
[SID103298456]
IC50 0.0047Inhibitory concentration against recombinant human Protein kinase C beta 1 [AID241462, Type: Literature]Protein kinase C beta type [gi:20141488]
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6
[SID103298456]
IC50 0.0047Inhibition of Protein kinase C beta 1 [AID163197, Type: Literature]Protein kinase C beta type [gi:20141488]
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7
[SID103298456]
IC50 0.0059Inhibition of Protein kinase C beta 2 [AID163341, Type: Literature]Protein kinase C beta type [gi:20141488]
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8
[SID103298456]
IC50 0.0059Inhibitory concentration against recombinant human Protein kinase C beta 2 [AID241463, Type: Literature]Protein kinase C beta type [gi:20141488]
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9
[SID103298456]
IC50 0.006Inhibition of Protein kinase C beta 2 [AID163350, Type: Literature]Protein kinase C beta type [gi:20141488]
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10
[SID103298456]
Kd 0.011Binding constant for PRKCE kinase domain [AID435320, Type: Literature]Protein kinase C epsilon type [gi:400135]
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11
[SID103298456]
Kd 0.011Binding constant for PRKCE kinase domain [AID625014, Type: Literature]Protein kinase C epsilon type [gi:400135]
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12
[SID103298456]
Kd 0.012Binding constant for PIM3 kinase domain [AID624802, Type: Literature]Serine/threonine-protein kinase pim-3 [gi:215274221]
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13
[SID103298456]
Kd 0.012Binding constant for PIM3 kinase domain [AID435679, Type: Literature]Serine/threonine-protein kinase pim-3 [gi:215274221]
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14
[SID103298456]
Kd 0.048Binding constant for YSK4 kinase domain [AID625136, Type: Literature]Mitogen-activated protein kinase kinase kinase 19 [gi:74755104]
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15
[SID103298456]
Kd 0.05Competitive binding affinity to PIM1 in presence of ATP [AID706713, Type: Literature]
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16
[SID103298456]
IC50 0.052Inhibition of Protein kinase C eta [AID163855, Type: Literature]Protein kinase C eta type [gi:281185512]
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17
[SID103298456]
Kd 0.055Average Binding Constant for PIM1 ; NA=Not Active at 10 uM [AID256650, Type: Literature]Serine/threonine-protein kinase pim-1 [gi:83305339]
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18
[SID103298456]
Kd 0.077Binding constant for HIPK3 kinase domain [AID625023, Type: Literature]Homeodomain-interacting protein kinase 3 [gi:61213741]
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19
[SID103298456]
Kd 0.088Binding constant for ERK8 kinase domain [AID624715, Type: Literature]Mitogen-activated protein kinase 15 [gi:74760462]
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20
[SID103298456]
Kd 0.088Binding constant for ERK8 kinase domain [AID435405, Type: Literature]Mitogen-activated protein kinase 15 [gi:74760462]
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21
[SID103298456]
Kd 0.09Average Binding Constant for STK3_m ; NA=Not Active at 10 uM [AID256574, Type: Literature]Serine/threonine-protein kinase 3 [gi:46577548]
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22
[SID103298456]
Kd 0.097Binding constant for TAOK3 kinase domain [AID625101, Type: Literature]Serine/threonine-protein kinase TAO3 [gi:78099183]
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23
[SID103298456]
Kd 0.13Binding constant for FLT3(D835Y) kinase domain [AID624936, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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24
[SID103298456]
Kd 0.13Binding constant for FLT3(D835Y) kinase domain [AID435407, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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25
[SID103298456]
Kd 0.13Average Binding Constant for PIM2 ; NA=Not Active at 10 uM [AID256570, Type: Literature]Serine/threonine-protein kinase pim-2 [gi:20139243]
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26
[SID103298456]
Kd 0.13Competitive binding affinity to PIM2 in presence of ATP [AID706712, Type: Literature]
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27
[SID103298456]
Kd 0.14Binding constant for HIPK2 kinase domain [AID625129, Type: Literature]Homeodomain-interacting protein kinase 2 [gi:21431782]
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28
[SID103298456]
Kd 0.17Binding constant for MAP3K3 kinase domain [AID624865, Type: Literature]Mitogen-activated protein kinase kinase kinase 3 [gi:160332306]
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29
[SID103298456]
IC50 0.2Inhibition of PIM1 expressed in Escherichia coli by thermal shift assay [AID325522, Type: Literature]
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30
[SID103298456]
EC50 0.21Effective concentration for 50% inhibition of plasminogen activator activity relative to control by beta-PDBu stimulation [AID67963, Type: Literature]
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31
[SID103298456]
Kd 0.21Binding constant for S6K1 kinase domain [AID624906, Type: Literature]Ribosomal protein S6 kinase beta-1 [gi:54041234]
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32
[SID103298456]
Kd 0.21Binding constant for FLT3(D835H) kinase domain [AID624935, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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33
[SID103298456]
Kd 0.21Binding constant for FLT3(D835H) kinase domain [AID435406, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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34
[SID103298456]
Kd 0.22Average Binding Constant for STK4 ; NA=Not Active at 10 uM [AID256586, Type: Literature]Serine/threonine-protein kinase 4 [gi:13124559]
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35
[SID103298456]
Kd 0.23Binding constant for HIPK1 kinase domain [AID624726, Type: Literature]Homeodomain-interacting protein kinase 1 [gi:34395641]
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36
[SID103298456]
Kd 0.24Binding constant for ICK kinase domain [AID625090, Type: Literature]Serine/threonine-protein kinase ICK [gi:48428273]
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37
[SID103298456]
Kd 0.25Binding constant for DYRK1A kinase domain [AID624712, Type: Literature]Dual specificity tyrosine-phosphorylation-regulated kinase 1A [gi:3219996]
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38
[SID103298456]
IC50 0.25Inhibition of Protein kinase C delta [AID163379, Type: Literature]Protein kinase C delta type [gi:205371776]
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39
[SID103298456]
Kd 0.27Average Binding Constant for FLT3 ; NA=Not Active at 10 uM [AID256620, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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40
[SID103298456]
Kd 0.27Binding constant for PIM1 kinase domain [AID435931, Type: Literature]Serine/threonine-protein kinase pim-1 [gi:83305339]
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41
[SID103298456]
Kd 0.27Binding constant for PIM1 kinase domain [AID624878, Type: Literature]Serine/threonine-protein kinase pim-1 [gi:83305339]
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42
[SID103298456]
Kd 0.28Binding constant for RSK3(Kin.Dom.1-N-terminal) kinase domain [AID625127, Type: Literature]Ribosomal protein S6 kinase alpha-2 [gi:90110031]
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43
[SID103298456]
Kd 0.28Binding constant for RPS6KA2(Kin.Dom.1 - N-terminal) kinase domain [AID436050, Type: Literature]Ribosomal protein S6 kinase alpha-2 [gi:90110031]
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44
[SID103298456]
Kd 0.28Binding constant for FLT3(ITD) kinase domain [AID624937, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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45
[SID103298456]
Kd 0.28Binding constant for FLT3(ITD) kinase domain [AID435310, Type: Literature]Receptor-type tyrosine-protein kinase FLT3 [gi:156630887]
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46
[SID103298456]
Kd 0.28Binding constant for DMPK kinase domain [AID624950, Type: Literature]Myotonin-protein kinase [gi:363548519]
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47
[SID103298456]
Kd 0.28Binding constant for DMPK kinase domain [AID435285, Type: Literature]Myotonin-protein kinase [gi:363548519]
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48
[SID103298456]
Kd 0.28Binding constant for CDK4-cyclinD1 kinase domain [AID624780, Type: Literature]Cyclin-dependent kinase 4 [gi:1168867]
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49
[SID103298456]
Kd 0.28Binding constant for CDK4-cyclinD3 kinase domain [AID624781, Type: Literature]Cyclin-dependent kinase 4 [gi:1168867]
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50
[SID103298456]
Kd 0.28Binding constant for LOK kinase domain [AID625030, Type: Literature]Serine/threonine-protein kinase 10 [gi:12643358]
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