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ruboxistaurin (CID 153999) - Compound BioActivity Data
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BioActivity Outcomes:
Active(264)
 
 
Inactive(151)
 
 
Inconclusive(1)
 
 
Unspecified(650)
 
 
Top Targets:
PTKc Abl(32)
 
 
 
PTKc EGFR(23)
 
 
 
 
STKc RSK N(22)
 
 
 
 
ig(18)
 
 
 
PKc like(18)
 
 
 
 
BioAssay Types:
Literature(994)
 
 
 
 
 
Confirmatory(66)
 
 
 
Screening(1)
 
 
BioActivity Types:
Kd(881)
 
 
 
 
IC50(32)
 
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 989    Data Row: 1066   Total Pages: 54   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103298456]
Kd 0.0025Binding constant for PRKCQ kinase domain [AID435321, Type: Literature]Protein kinase C theta type [gi:20141582]
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2
[SID103298456]
Kd 0.0025Binding constant for PRKCQ kinase domain [AID625051, Type: Literature]Protein kinase C theta type [gi:20141582]
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3
[SID103298456]
Kd 0.0036Binding constant for PRKCD kinase domain [AID435553, Type: Literature]Protein kinase C delta type [gi:205371776]
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4
[SID103298456]
Kd 0.0036Binding constant for PRKCD kinase domain [AID625048, Type: Literature]Protein kinase C delta type [gi:205371776]
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5
[SID103298456]
IC50 0.0047Inhibition of Protein kinase C beta 1 [AID163197, Type: Literature]Protein kinase C beta type [gi:20141488]
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6
[SID103298456]
IC50 0.0047Inhibitory concentration against recombinant human Protein kinase C beta 1 [AID241462, Type: Literature]Protein kinase C beta type [gi:20141488]
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7
[SID103298456]
IC50 0.0059Inhibitory concentration against recombinant human Protein kinase C beta 2 [AID241463, Type: Literature]Protein kinase C beta type [gi:20141488]
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8
[SID103298456]
IC50 0.0059Inhibition of Protein kinase C beta 2 [AID163341, Type: Literature]Protein kinase C beta type [gi:20141488]
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9
[SID103298456]
IC50 0.006Inhibition of Protein kinase C beta 2 [AID163350, Type: Literature]Protein kinase C beta type [gi:20141488]
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10
[SID103298456]
Kd 0.011Binding constant for PRKCE kinase domain [AID435320, Type: Literature]Protein kinase C epsilon type [gi:400135]
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11
[SID103298456]
Kd 0.011Binding constant for PRKCE kinase domain [AID625014, Type: Literature]Protein kinase C epsilon type [gi:400135]
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12
[SID103298456]
Kd 0.012Binding constant for PIM3 kinase domain [AID435679, Type: Literature]Serine/threonine-protein kinase pim-3 [gi:215274221]
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13
[SID103298456]
Kd 0.012Binding constant for PIM3 kinase domain [AID624802, Type: Literature]Serine/threonine-protein kinase pim-3 [gi:215274221]
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14
[SID103298456]
Kd 0.048Binding constant for YSK4 kinase domain [AID625136, Type: Literature]Mitogen-activated protein kinase kinase kinase 19 [gi:74755104]
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15
[SID103298456]
Kd 0.05Competitive binding affinity to PIM1 in presence of ATP [AID706713, Type: Literature]
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16
[SID103298456]
IC50 0.052Inhibition of Protein kinase C eta [AID163855, Type: Literature]Protein kinase C eta type [gi:281185512]
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17
[SID103298456]
Kd 0.055Average Binding Constant for PIM1; NA=Not Active at 10 uM [AID256650, Type: Literature]Serine/threonine-protein kinase pim-1 [gi:83305339]
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18
[SID103298456]
Kd 0.077Binding constant for HIPK3 kinase domain [AID625023, Type: Literature]Homeodomain-interacting protein kinase 3 [gi:61213741]
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19
[SID103298456]
Kd 0.088Binding constant for ERK8 kinase domain [AID435405, Type: Literature]Mitogen-activated protein kinase 15 [gi:74760462]
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20
[SID103298456]
Kd 0.088Binding constant for ERK8 kinase domain [AID624715, Type: Literature]Mitogen-activated protein kinase 15 [gi:74760462]
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