ZINC01432451 (CID 1511959) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(52)
 
 
Inactive(538)
 
 
Inconclusive(29)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(19)
 
 
 
Bcl-2 like(10)
 
 
alkPPc(10)
 
 
 
7TM GPCR Srsx(8)
 
 
Tryp SPc(6)
 
 
 
BioAssay Types:
Screening(411)
 
 
 
 
Confirmatory(194)
 
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(126)
 
 
 
 
 
IC50(41)
 
 
 
EC50(16)
 
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 620    Data Row: 620   Total Pages: 13   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID24812198]
AbsAC35_uM 0.59Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (HB3 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-06_Inhibitor_Dose_CherryPick_Activity [AID652041, Type: confirmatory]
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2
[SID24812198]
AbsAC35_uM 0.836Cell-based secondary assay to test the inhibitory activity of small molecule on Plasmodium flaciparum (3D7 strain) survival in red blood cells Measured in Cell-Based System Using Plate Reader - 2120-05_Inhibitor_Dose_CherryPick_Activity [AID652047, Type: confirmatory]
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3
[SID24812198]
IC50 1.27Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2784, Type: confirmatory]APLNR gene product [Homo sapiens] [gi:4885057]
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4
[SID24812198]
IC50 1.27Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2784, Type: confirmatory]APLNR gene product [Homo sapiens] [gi:4885057]
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5
[SID24812198]
Potency 1.8356qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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6
[SID24812198]
Potency 1.8356qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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7
[SID24812198]
Potency 1.8356qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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8
[SID24812198]
IC50 2.473Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-1 (PLIN1) [AID651672, Type: confirmatory]PLIN1 gene product [Homo sapiens] [gi:223718203]
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9
[SID24812198]
AbsAC1000_uM 2.702In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_Dose_CherryPick_Activity [AID540271, Type: confirmatory]HSP40, subfamily A, putative [Plasmodium falciparum 3D7] [gi:124809271]
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10
[SID24812198]
IC50 2.856Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID651677, Type: confirmatory]ABHD5 gene product [Homo sapiens] [gi:31542303]
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11
[SID24812198]
Potency 3.1623qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): Confirmation of Cherrypicks [AID624002, Type: confirmatory]isocitrate dehydrogenase 1 [Homo sapiens] [gi:89573979]
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12
[SID24812198]
Potency 3.1623qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): Confirmation of Cherrypicks [AID624002, Type: confirmatory]isocitrate dehydrogenase 1 [Homo sapiens] [gi:89573979]
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13
[SID24812198]
Potency 3.1623qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): Confirmation of Cherrypicks [AID624002, Type: confirmatory]isocitrate dehydrogenase 1 [Homo sapiens] [gi:89573979]
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14
[SID24812198]
Potency 3.5481qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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15
[SID24812198]
Potency 3.5481qHTS for Inhibitors of Tau Fibril Formation, Thioflavin T Binding [AID1460, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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16
[SID24812198]
IC50 4.266Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization [AID651720, Type: confirmatory]HNF4A gene product [Homo sapiens] [gi:31077205]
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17
[SID24812198]
IC50 4.266Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization [AID651720, Type: confirmatory]HNF4A gene product [Homo sapiens] [gi:31077205]
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18
[SID24812198]
IC50 4.266Counterscreen for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5): Luminescence-based biochemical high throughput dose response assay to identify inhibitors of Hepatocyte nuclear factor 4 (HNF4) dimerization [AID651720, Type: confirmatory]HNF4A gene product [Homo sapiens] [gi:31077205]
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19
[SID24812198]
IC50 4.299Luminescence-based biochemical high throughput dose response assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) produced in HEK293T cells [AID651733, Type: confirmatory]ABHD5 gene product [Homo sapiens] [gi:31542303]
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20
[SID24812198]
Potency 4.6109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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21
[SID24812198]
Potency 4.6109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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22
[SID24812198]
Potency 4.6109qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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23
[SID24812198]
Potency 5.0119qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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24
[SID24812198]
EC50 6.54Dose Response confirmation of activators of hexokinase domain containing I (HKDC1) in the hexokinase 1 selectivity assay [AID504762, Type: confirmatory]hexokinase-1 isoform HKI [Homo sapiens] [gi:188497754]
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25
[SID24812198]
EC50 8.32Dose Response confirmation of activators of hexokinase domain containing I (HKDC1) [AID504730, Type: confirmatory]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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26
[SID24812198]
IC50 8.724Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor [AID463214, Type: confirmatory]type-1 angiotensin II receptor [Homo sapiens] [gi:4501997]
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27
[SID24812198]
IC50 8.724Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor [AID463214, Type: confirmatory]type-1 angiotensin II receptor [Homo sapiens] [gi:4501997]
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28
[SID24812198]
Potency 10qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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29
[SID24812198]
Potency 11.2202qHTS for Inhibitors of TGF-b: Cytotox Counterscreen [AID588856, Type: confirmatory]
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30
[SID24812198]
Potency 11.2202qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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31
[SID24812198]
Potency 11.2202qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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32
[SID24812198]
EC50 14.959HTS Dose response counterscreen for assays utilizing the enzyme, beta-galactosidase - Set 2 [AID485352, Type: confirmatory]LacZ protein [Escherichia coli] [gi:18073591]
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33
[SID24812198]
Potency 20.7491qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS [AID602179, Type: confirmatory]isocitrate dehydrogenase 1 [Homo sapiens] [gi:89573979]
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34
[SID24812198]
Potency 20.7491qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS [AID602179, Type: confirmatory]isocitrate dehydrogenase 1 [Homo sapiens] [gi:89573979]
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35
[SID24812198]
Potency 20.7491qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS [AID602179, Type: confirmatory]isocitrate dehydrogenase 1 [Homo sapiens] [gi:89573979]
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36
[SID24812198]
Potency 22.3872qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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37
[SID24812198]
Potency 23.1093A quantitative high throughput screen for small molecules that induce DNA re-replication in MCF 10a normal breast cells. [AID624296, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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38
[SID24812198]
CC50 24.35Vero 76 Cytoxicity Assay for VEEV Compounds [AID588719, Type: confirmatory]
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39
[SID24812198]
EC50 44.236Fluorescent Polarization Homogeneous Dose Response HTS to Indentify Inhibitors of POS-1 Binding to mex-3-RNA [AID1964, Type: confirmatory]POsterior Segregation family member (pos-1) [Caenorhabditis elegans] [gi:17562800]
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40
[SID24812198]
 uHTS Fluorescent assay for identification of activators of hexokinase domain containing I (HKDC1) [AID493187, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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41
[SID24812198]
 MLPCN maternal gene expression-MEX-5 TCR-2 binding assay-Primary Screen [AID1832, Type: screening]Zinc finger protein mex- [gi:55976631]
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42
[SID24812198]
 MLPCN maternal gene expression-MEX-5 TCR-2 binding assay-Primary Screen [AID1832, Type: screening]Zinc finger protein mex- [gi:55976631]
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43
[SID24812198]
 In vivo-based yeast HTS to detect compounds rescuing yeast growth/survival of Plasmodium Falciparum HSP40-mediated toxicity Measured in Whole Organism System Using Plate Reader - 2120-01_Inhibitor_SinglePoint_HTS_Activity [AID504582, Type: screening]HSP40, subfamily A, putative [Plasmodium falciparum 3D7] [gi:124809271]
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44
[SID24812198]
 Luminescence-based biochemical high throughput confirmation assay for inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID651612, Type: screening]ABHD5 gene product [Homo sapiens] [gi:31542303]
View
45
[SID24812198]
 Luminescence-based biochemical primary high throughput screening assay to identify inhibitors of the interaction of the lipase co-activator protein, abhydrolase domain containing 5 (ABHD5) with perilipin-5 (MLDP; PLIN5) [AID602281, Type: screening]ABHD5 gene product [Homo sapiens] [gi:31542303]
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46
[SID24812198]
 Single concentration confirmation of activators of hexokinase domain containing I (HKDC1) [AID504708, Type: screening]putative hexokinase HKDC1 [Homo sapiens] [gi:156151420]
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47
[SID24812198]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4) (1536 HTS) [AID485272, Type: screening]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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48
[SID24812198]
 Fluorescence polarization-based primary biochemical high throughput screening assay to identify inhibitors of Protein Arginine Deiminase 4 (PAD4) (1536 HTS) [AID485272, Type: screening]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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49
[SID24812198]
 Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of Protein Arginine Deiminase 4 (PAD4) [AID488796, Type: screening]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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50
[SID24812198]
 Fluorescence polarization-based biochemical high throughput confirmation assay for inhibitors of Protein Arginine Deiminase 4 (PAD4) [AID488796, Type: screening]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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