Bookmark and Share
alpha-Tocopherol (CID 14985) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(80)
 
 
Inactive(839)
 
 
Inconclusive(52)
 
 
Unspecified(360)
 
 
Top Targets:
7TM GPCR Srx(31)
 
 
 
7TM GPCR Srsx(28)
 
 
 
NR LBD ER(23)
 
 
 
 
NR LBD AR(22)
 
 
 
 
p450(17)
 
 
 
BioAssay Types:
Literature(398)
 
 
 
 
 
Confirmatory(389)
 
 
 
 
Screening(345)
 
 
Summary(54)
 
 
 
BioActivity Types:
Potency(408)
 
 
 
 
IC50(194)
 
 
 
 
EC50(10)
 
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1019    Data Row: 1331   Total Pages: 27   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103166767]
EC50 0.2Neuroprotective activity against glutamate-mediated oxidative stress-induced cell death in mouse HT22 cells assessed as survival after 24 hrs by MTT assay [AID464438, Type: Literature]
View
2
[SID103166767]
EC50 0.234Cytoprotective activity against BSO-induced human FRDA primary patient fibroblasts compound pretreated 12 hrs prior to BSO-induction measured after 48 hrs by calcein-AM-based cell viability assay [AID642426, Type: Literature]
View
3
[SID103166767]
IC50 0.9Antioxidant activity in rat liver microsomes assessed as inhibition of ferrous-cystine-induced lipid peroxidation after 15 mins [AID287012, Type: Literature]
View
4
[SID103166767]
IC50 1.5inhibitory concentration against auto-oxidative lipid peroxidationin canine brain homogenate [AID248417, Type: Literature]
View
5
[SID103166767]
IC50 1.5Concentration of the test compound required to inhibit the auto oxidative lipid peroxidations in canine brain homogenates by 50% was determined [AID48968, Type: Literature]
View
6
[SID103166767]
IC50 2.3Inhibition of DPPH radical scavenging activity [AID290179, Type: Literature]
View
7
[SID103166767]
Kd 2.42Displacement of NBD-Toc from human recombinant alphaTTP [AID454510, Type: Literature]
View
8
[SID103166767]
IC50 3.4Antioxidant activity assessed as superoxide radical anion scavenging activity [AID287996, Type: Literature]
View
9
[SID103166767]
IC50 4Antioxidant activity assessed as inhibition of endothelial cell-induced human LDL oxidation [AID360575, Type: Literature]
View
10
[SID103166767]
IC50 4.68Inhibition of lipid peroxidation in Sprague-Dawley rat brain after 30 mins by TBARS assay [AID314540, Type: Literature]
View
11
[SID103166767]
IC50 4.68Inhibitory concentration against lipid peroxidation in rat [AID247699, Type: Literature]
View
12
[SID103166767]
IC50 4.68Compound was tested for its inhibitory concentration against formation of lipid peroxides in rat brain homogenates by thiobarbituric acid reactive substances (TBARS) assay according to the method of Stocks. [AID195714, Type: Literature]
View
13
[SID103166767]
IC50 5.9Inhibitory activity against lipid peroxidation of egg-phosphatidylcholine (PC) liposome caused by lipid-soluble radical initiator [2,2'-azobis(2,4- dimethylvaleronitrile] (AMVN) [AID68460, Type: Literature]
View
14
[SID103166767]
IC50 6Antioxidant activity assessed as ABTS radical scavenging activity after 12 hrs by ELISA [AID380089, Type: Literature]
View
15
[SID103166767]
IC50 6.78Antioxidant activity in Wistar rat brain homogenates assessed as inhibition of lipid peroxidation by spectrophotometry based TBARS assay [AID678024, Type: Literature]
View
16
[SID103166767]
IC50 8.2Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins [AID494206, Type: Literature]
View
17
[SID103166767]
IC50 8.3Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins [AID356135, Type: Literature]
View
18
[SID103166767]
IC50 8.3Antioxidant activity assessed as DPPH free radical scavenging activity [AID356427, Type: Literature]
View
19
[SID103166767]
IC50 8.8ABTS radical scavenging activity [AID276002, Type: Literature]
View
20
[SID103166767]
IC50 9Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins [AID647574, Type: Literature]
View
21
[SID103166767]
IC50 9.89DPPH radical scavenging activity after 30 mins [AID309192, Type: Literature]
View
22
[SID103166767]
IC50 10Compound was evaluated for the inhibition of human LDL oxidation mediated by copper(II). [AID88961, Type: other]
View
23
[SID103166767]
IC50 11.4Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins by spectrophotometry [AID650645, Type: Literature]
View
24
[SID103166767]
IC50 11.5DPPH radical scavenging activity [AID276004, Type: Literature]
View
25
[SID103166767]
IC50 11.6Antioxidant activity assessed as ABTS radical scavenging activity [AID287997, Type: Literature]
View
26
[SID103166767]
IC50 12Compound was evaluated for prevention of spontaneous lipid peroxidation in rat brain homogenate. [AID181705, Type: Literature]
View
27
[SID103166767]
IC50 12.5Antioxidant activity assessed as inhibition of lipid peroxidation [AID640885, Type: Literature]
View
28
[SID103166767]
IC50 13.2Compound was tested for [Ca2+] overload inhibitory activity in the veratridine-induced [Ca2+] overload model of rat cardiac myocytes. [AID196205, Type: Literature]
View
29
[SID103166767]
IC50 13.6Compound was evaluated for the inhibition of HUVEC-induced LDL oxidation [AID88960, Type: other]
View
30
[SID103166767]
IC50 14In vitro inhibition of lipid autoxidation (TBARS formation) of rat brain homogenate [AID195549, Type: Literature]
View
31
[SID103166767]
IC50 14The IC50 value was measured for inhibition of lipid autoxidation in rat brain homogenate. [AID195554, Type: Literature]
View
32
[SID103166767]
IC50 18.1Antioxidant activity assessed as DPPH free radical scavenging [AID406379, Type: Literature]
View
33
[SID103166767]
EC50 19Free radical scavenging assessed as 50% reduction in DPPH absorbance (516 nm) [AID228869, Type: Literature]
View
34
[SID103166767]
EC50 19.9Antioxidant activity assessed as DPPH free radical scavenging activity [AID377909, Type: Literature]
View
35
[SID103166767]
IC50 20.1Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins [AID333687, Type: Literature]
View
36
[SID103166767]
IC50 22.8Antioxidant activity assessed as DPPH radical scavenging activity [AID354424, Type: Literature]
View
37
[SID103166767]
IC50 23.25Antioxidant activity assessed as superoxide radical scavenging activity by phenazin methosulphate-NADH-NBT assay [AID422294, Type: Literature]
View
38
[SID103166767]
IC50 26.8Antioxidant activity assessed as inhibition of ABTS radical formation for 15 mins by spectrophotometric analysis [AID736486, Type: Literature]
View
39
[SID103166767]
ED50 27.21Antioxidant activity assessed as DPPH radical scavenging activity by ELISA [AID735840, Type: Literature]
View
40
[SID103166767]
IC50 28Antioxidant activity assessed as DPPH radicle scavenging activity after 30 mins by spectrometric analysis [AID633940, Type: Literature]
View
41
[SID103166767]
IC50 28Tested in vitro for the inhibition of iron-dependent lipid peroxidation against rat brain homogenates, by malondialdehyde (MDA) formation assay [AID180509, Type: Literature]
View
42
[SID103166767]
ED50 28.4Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins [AID464263, Type: Literature]
View
43
[SID103166767]
IC50 30Ability to inhibit iron-dependent lipid peroxidation in rat brain homogenate using MDA (malonyldialdehyde) formation assay [AID181514, Type: Literature]
View
44
[SID103166767]
IC50 31.1Antioxidant activity assessed as inhibition of DPPH radical formation measured every min for 45 mins by spectrophotometric analysis [AID736487, Type: Literature]
View
45
[SID103166767]
IC50 35.7Inhibition of Fe2+-induced lipid peroxidation in rat brain homogenate [AID312787, Type: Literature]
View
46
[SID103166767]
IC50 37.5Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins by multilabel counter [AID379523, Type: Literature]
View
47
[SID103166767]
IC50 40.3Inhibitory activity against lipid peroxidation of egg-phosphatidylcholine (PC) liposome caused by water-soluble radical initiator [2,2'-azobis(2-amidinopropane) dihydrochloride] (AAPH) [AID68587, Type: Literature]
View
48
[SID103166767]
The concentration producing 50% protection against L-HCA-mediated neurotoxicity in HT-22 hippocampal cell line. [AID85745, Type: Literature]
View
49
[SID103166767]
Compound was tested in vitro for its neuroprotective activity against L-homocysteic acid(L-HCA) cytotoxicity in murine HT-22 hippocampal cell culture monitored by MTT reduction assay [AID85737, Type: Literature]
View
50
[SID103166767]
Tested in vitro for its neuroprotective activity against L-homocysteic acid(L-HCA) cytotoxicity, in murine HT-22 hippocampal cell culture, monitored by LDH assay. [AID85738, Type: Literature]
View