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alpha-Tocopherol (CID 14985) - Compound BioActivity Data
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BioActivity Outcomes:
Active(86)
 
 
Inactive(859)
 
 
Inconclusive(47)
 
 
Unspecified(412)
 
 
Top Targets:
7TM GPCR Srx(31)
 
 
 
7TM GPCR Srsx(28)
 
 
 
NR LBD ER(23)
 
 
 
 
NR LBD AR(22)
 
 
 
 
p450(17)
 
 
 
BioAssay Types:
Confirmatory(509)
 
 
 
 
 
Literature(451)
 
 
 
 
 
Screening(346)
 
 
Summary(54)
 
 
 
BioActivity Types:
Potency(410)
 
 
 
 
IC50(195)
 
 
 
 
EC50(12)
 
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1085    Data Row: 1404   Total Pages: 71   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103166767]
EC50 0.2Neuroprotective activity against glutamate-mediated oxidative stress-induced cell death in mouse HT22 cells assessed as survival after 24 hrs by MTT assay [AID464438, Type: Literature]
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2
[SID103166767]
EC50 0.234Cytoprotective activity against BSO-induced human FRDA primary patient fibroblasts compound pretreated 12 hrs prior to BSO-induction measured after 48 hrs by calcein-AM-based cell viability assay [AID642426, Type: Literature]
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3
[SID103166767]
IC50 0.9Antioxidant activity in rat liver microsomes assessed as inhibition of ferrous-cystine-induced lipid peroxidation after 15 mins [AID287012, Type: Literature]
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4
[SID103166767]
IC50 1.5inhibitory concentration against auto-oxidative lipid peroxidation in canine brain homogenate [AID248417, Type: Literature]
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5
[SID103166767]
IC50 1.5Concentration of the test compound required to inhibit the auto oxidative lipid peroxidations in canine brain homogenates by 50% was determined [AID48968, Type: Literature]
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6
[SID103166767]
IC50 2.3Inhibition of DPPH radical scavenging activity [AID290179, Type: Literature]
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7
[SID103166767]
Kd 2.42Displacement of NBD-Toc from human recombinant alphaTTP [AID454510, Type: Literature]
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8
[SID103166767]
IC50 3.4Antioxidant activity assessed as superoxide radical anion scavenging activity [AID287996, Type: Literature]
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9
[SID103166767]
IC50 4Antioxidant activity assessed as inhibition of endothelial cell-induced human LDL oxidation [AID360575, Type: Literature]
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10
[SID103166767]
IC50 4.68Inhibitory concentration against lipid peroxidation in rat [AID247699, Type: Literature]
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11
[SID103166767]
IC50 4.68Inhibition of lipid peroxidation in Sprague-Dawley rat brain after 30 mins by TBARS assay [AID314540, Type: Literature]
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12
[SID103166767]
IC50 4.68Compound was tested for its inhibitory concentration against formation of lipid peroxides in rat brain homogenates by thiobarbituric acid reactive substances (TBARS) assay according to the method of Stocks. [AID195714, Type: Literature]
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13
[SID103166767]
IC50 5.9Inhibitory activity against lipid peroxidation of egg-phosphatidylcholine (PC) liposome caused by lipid-soluble radical initiator [2,2'-azobis(2,4- dimethylvaleronitrile] (AMVN) [AID68460, Type: Literature]
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14
[SID103166767]
IC50 6Antioxidant activity assessed as ABTS radical scavenging activity after 12 hrs by ELISA [AID380089, Type: Literature]
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15
[SID103166767]
IC50 6.78Antioxidant activity in Wistar rat brain homogenates assessed as inhibition of lipid peroxidation by spectrophotometry based TBARS assay [AID678024, Type: Literature]
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16
[SID103166767]
IC50 8.2Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins [AID494206, Type: Literature]
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17
[SID103166767]
IC50 8.3Antioxidant activity assessed as DPPH radical scavenging activity after 30 mins [AID356135, Type: Literature]
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18
[SID103166767]
IC50 8.3Antioxidant activity assessed as DPPH free radical scavenging activity [AID356427, Type: Literature]
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19
[SID103166767]
IC50 8.8ABTS radical scavenging activity [AID276002, Type: Literature]
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20
[SID103166767]
IC50 9Antioxidant activity assessed as DPPH free radical scavenging activity after 30 mins [AID647574, Type: Literature]
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