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BioActivity Data for Compound Glycyrrhizic Acid (CID 14982)

BioActivity Outcomes:
Active(16)
 
 
Inactive(217)
 
 
Inconclusive(21)
 
 
Unspecified(211)
 
 
Top Targets:
7tm 4(34)
 
 
 
NR LBD ER(23)
 
 
 
 
NR LBD AR(22)
 
 
 
 
 
p450(14)
 
 
 
 
NR LBD GR(13)
 
 
 
 
 
BioAssay Types:
Confirmatory(288)
 
 
 
 
 
Literature(100)
 
 
 
 
Summary(56)
 
 
 
 
Screening(4)
 
 
BioAssay Categories:
In vitro(145)
 
 
In vivo(3)
 
 
Biochemical(168)
 
 
 
 
Toxicity(32)
 
 
 
ADME(13)
 
 
Cell-based(167)
 
 
 
 
BioActivity Types:
Potency(215)
 
 
 
 
IC50(133)
 
 
 
Ki(5)
 
 
AC50(3)
 
 
EC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 340    Data Row: 465   Total Pages: 24   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID160703999]
IC50 0.0004Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay [AID664592, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 2 [gi:30316367]
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2
[SID160703999]
IC50 0.0007Inhibition of human 11beta-HSD2 expressed in human HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay [AID634026, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 2 [gi:30316367]
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3
[SID160703999]
EC50 0.001Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA [AID657950, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 2 [gi:30316367]
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4
[SID160703999]
IC50 0.001Inhibition of human microsomal 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay [AID433139, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 2 [gi:30316367]
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5
[SID160703999]
IC50 0.003Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay [AID664591, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:1706408]
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6
[SID160703999]
IC50 0.006Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay [AID664590, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:118569]
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7
[SID160703999]
EC50 0.008Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA [AID657949, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:1706408]
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8
[SID160703999]
IC50 0.008Inhibition of mouse microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay [AID433138, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:1706408]
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9
[SID160703999]
EC50 0.01Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA [AID657948, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:118569]
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10
[SID160703999]
IC50 0.01Inhibition of human microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay [AID433137, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:118569]
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11
[SID160703999]
IC50 0.015Inhibition of mouse liver microsome 11betaHSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay [AID431046, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:1706408]
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12
[SID160703999]
IC50 0.0186Inhibition of human 11beta-HSD1 expressed in human HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay [AID634024, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:118569]
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13
[SID160703999]
IC50 0.0295Inhibition of mouse 11beta-HSD1 expressed in human HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay [AID634025, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:1706408]
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14
[SID144206976]
Potency-Replicate_1 13.3332qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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15
[SID144205073]
Potency-Replicate_1 13.3332qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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16
[SID144205073]
Ratio Potency (uM) 17.9333qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720719, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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17
[SID160703999]
Ki 0.84TP_TRANSPORTER: inhibition of DNP-SG uptake in bile canalicular membrane vesicles from SD rat [AID681175, Type: Literature]Canalicular multispecific organic anion transporter 1 [gi:3219824]
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18
[SID160703999]
Ki 1.91TP_TRANSPORTER: inhibition of SN-38 uptake in bile canalicular membrane vesicles from SD rat [AID679806, Type: Literature]Canalicular multispecific organic anion transporter 1 [gi:3219824]
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19
[SID160703999]
Ki 6.1TP_TRANSPORTER: inhibition of E1S uptake in Xenopus laevis oocytes [AID681650, Type: Literature]Solute carrier organic anion transporter family member 1B2 [gi:317373278]
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20
[SID160703999]
Ki 12.5TP_TRANSPORTER: inhibition of BSP uptake in Xenopus laevis oocytes [AID680384, Type: Literature]Solute carrier organic anion transporter family member 1B3 [gi:27734563]
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