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Glycyrrhizic Acid (CID 14982) - Compound BioActivity Data
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BioActivity Outcomes:
Active(11)
 
 
Inactive(188)
 
 
Inconclusive(30)
 
 
Unspecified(208)
 
 
Top Targets:
NR LBD ER(23)
 
 
 
 
NR LBD AR(22)
 
 
 
 
 
7TM GPCR Srsx(19)
 
 
 
7TM GPCR Srx(17)
 
 
p450(14)
 
 
 
 
BioAssay Types:
Confirmatory(164)
 
 
 
 
Literature(69)
 
 
 
Summary(54)
 
 
 
 
Screening(4)
 
 
BioActivity Types:
Potency(205)
 
 
 
 
IC50(125)
 
 
 
Ki(5)
 
 
AC50(3)
 
 
EC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 313    Data Row: 437   Total Pages: 9   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID160703999]
IC50 0.001Inhibition of human microsomal 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay [AID433139, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 2 [gi:30316367]
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2
[SID160703999]
EC50 0.001Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA [AID657950, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 2 [gi:30316367]
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3
[SID160703999]
IC50 0.008Inhibition of mouse microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay [AID433138, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:1706408]
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4
[SID160703999]
EC50 0.008Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA [AID657949, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:1706408]
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5
[SID160703999]
EC50 0.01Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA [AID657948, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:118569]
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6
[SID160703999]
IC50 0.01Inhibition of human microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay [AID433137, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:118569]
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7
[SID160703999]
IC50 0.015Inhibition of mouse liver microsome 11betaHSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay [AID431046, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:1706408]
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8
[SID144206976]
Potency-Replicate_1 6.6824qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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9
[SID144205073]
Potency-Replicate_1 13.3332qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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10
[SID144205073]
Potency-Replicate_1 15.089qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway [AID720691, Type: confirmatory]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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11
[SID144205073]
Ratio Potency (uM) 17.9333qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720719, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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12
[SID160703999]
Ki 0.84TP_TRANSPORTER: inhibition of DNP-SG uptake in bile canalicular membrane vesicles from SD rat [AID681175, Type: other]Canalicular multispecific organic anion transporter 1 [gi:3219824]
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13
[SID160703999]
Ki 1.91TP_TRANSPORTER: inhibition of SN-38 uptake in bile canalicular membrane vesicles from SD rat [AID679806, Type: other]Canalicular multispecific organic anion transporter 1 [gi:3219824]
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14
[SID160703999]
Ki 6.1TP_TRANSPORTER: inhibition of E1S uptake in Xenopus laevis oocytes [AID681650, Type: other]Solute carrier organic anion transporter family member 1B2 [gi:317373278]
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15
[SID160703999]
Ki 12.5TP_TRANSPORTER: inhibition of BSP uptake in Xenopus laevis oocytes [AID680384, Type: other]Solute carrier organic anion transporter family member 1B3 [gi:27734563]
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16
[SID160703999]
Ki 15.9TP_TRANSPORTER: inhibition of E1S uptake in Xenopus laevis oocytes [AID680745, Type: other]Solute carrier organic anion transporter family member 1B1 [gi:12643959]
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17
[SID160703999]
ED50 70Inhibition of HMGB1 in mouse RAW264.7 cells assessed as LPS-induced TNFalpha release treated for 2 hrs prior to LPS-challenge measured after 16 hrs by ELISA [AID723646, Type: Literature]High mobility group protein B1 [gi:52783747]
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18
[SID160703999]
IC50 82.4Hepatoprotective activity in mouse hepatocytes assessed inhibition of D-galactosamine/TNFalpha-induced cell death dosed administered before 30 mins of TNFalpha challenge measured after 18 hrs [AID359488, Type: Literature]
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19
[SID160703999]
IC50 100Inhibition of human recombinant PTP1B [AID265377, Type: Literature]Tyrosine-protein phosphatase non-receptor type 1 [gi:131467]
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20
[SID160703999]
Kd 150Binding affinity to HMGB1 (unknown origin) [AID723645, Type: Literature]High mobility group protein B1 [gi:123369]
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21
[SID160703999]
IC50 200Hepatoprotective activity against D-galactosamine/TNFalpha-induced cell death in primary cultured mouse hepatocytes treated for 30 mins before TNFalpha challenge measured after 18 hrs by MTT assay [AID359156, Type: Literature]
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22
[SID160703999]
IC50 381Inhibition of TPA-induced EBV-early antigen activation in human Raji cells after 48hrs by indirect immunofluorescence technique [AID348191, Type: Literature]
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23
[SID160703999]
IC50 822Inhibition of rabbit muscle glycogen phosphorylase A assessed as phosphate release from glucose-1-phosphate [AID404873, Type: Literature]Glycogen phosphorylase, muscle form [gi:6093713]
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24
[SID160703999]
IC50 DRUGMATRIX: Estrogen ERbeta radioligand binding (ligand: [3H] Estradiol) [AID625259, Type: other]Estrogen receptor beta [gi:6166154]
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25
[SID160703999]
IC50 DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT4 radioligand binding (ligand: [3H] GR-113808) [AID625220, Type: other]5-hydroxytryptamine receptor 4 [gi:6224984]
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26
[SID160703999]
IC50 DRUGMATRIX: CYP450, 2C9 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625248, Type: other]Cytochrome P450 2C9 [gi:6686268]
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27
[SID160703999]
Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake at 20 uM by scintillation counting [AID699539, Type: Literature]Solute carrier organic anion transporter family member 1B1 [gi:12643959]
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28
[SID160703999]
IC50 DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) [AID625203, Type: other]Alpha-2C adrenergic receptor [gi:20141211]
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29
[SID160703999]
Inhibition of human recombinant 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [1,2-3H]cortisone to cortisol at 1 uM after 10 mins by scintillation counting [AID456095, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:118569]
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30
[SID160703999]
TP_TRANSPORTER: inhibition of E1S uptake (E1S: 0.05 uM, GL: 100 uM) in Xenopus laevis oocytes [AID681842, Type: other]Solute carrier organic anion transporter family member 1A4 [gi:3914190]
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31
[SID160703999]
IC50 DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) [AID625244, Type: other]Prostaglandin G/H synthase 2 [gi:3915797]
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32
[SID160703999]
Inhibition of human liver OATP1B3 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E17-betaG uptake at 20 uM incubated for 5 mins by scintillation counting [AID699540, Type: Literature]Solute carrier organic anion transporter family member 1B3 [gi:27734563]
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33
[SID160703999]
TP_TRANSPORTER: inhibition of E1S uptake (E1S: 0.05 uM, GL: 100 uM) in Xenopus laevis oocytes [AID682244, Type: other]Solute carrier organic anion transporter family member 1A5 [gi:27735247]
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34
[SID160703999]
Inhibition of human recombinant 11beta-HSD2 expressed in HEK293 cells assessed as oxidation of [1,2,6,7-3H]cortisol to cortisone at 1 uM after 10 mins by scintillation counting [AID456097, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 2 [gi:30316367]
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35
[SID160703999]
IC50 DRUGMATRIX: Muscarinic M4 radioligand binding (ligand: [3H] N-Methylscopolamine) [AID625154, Type: other]Muscarinic acetylcholine receptor M4 [gi:23503039]
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36
[SID160703999]
TP_TRANSPORTER: inhibition of E1S uptake (E1S: 0.05 uM, GL: 100 uM) in Xenopus laevis oocytes [AID680383, Type: other]Solute carrier organic anion transporter family member 1B3 [gi:27734563]
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37
[SID160703999]
DRUGMATRIX: Protein Tyrosine Phosphatase, PTPRC (CD45) enzyme inhibition (substrate: DiFMUP) [AID625188, Type: other]Receptor-type tyrosine-protein phosphatase C [gi:33112650]
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38
[SID160703999]
IC50 DRUGMATRIX: Adrenergic beta1 radioligand binding (ligand: [125I] Cyanopindolol) [AID625204, Type: other]Beta-1 adrenergic receptor [gi:48429211]
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39
[SID160703999]
IC50 DRUGMATRIX: Melanocortin MC4 radioligand binding (ligand: [125I] NDP-alpha-MSH) [AID625148, Type: other]Melanocortin receptor 4 [gi:60392672]
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40
[SID160703999]
IC50 DRUGMATRIX: CYP450, 2C19 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625247, Type: other]Cytochrome P450 2C19 [gi:60416369]
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41
[SID160703999]
IC50 DRUGMATRIX: Sigma1 radioligand binding (ligand: [3H] Haloperidol) [AID625223, Type: other]Sigma non-opioid intracellular receptor 1 [gi:74752153]
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42
[SID160703999]
IC50 DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020) [AID625172, Type: other]Progesterone receptor [gi:75071465]
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43
[SID160703999]
IC50 DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) [AID625249, Type: other]Cytochrome P450 2D6 [gi:84028191]
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44
[SID160703999]
DRUGMATRIX: Chemokine CXCR1 (IL-8A) [AID625240, Type: other]C-X-C chemokine receptor type 1 [gi:108936015]
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45
[SID160703999]
IC50 DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) [AID625251, Type: other]Cytochrome P450 3A4 [gi:116241312]
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46
[SID160703999]
IC50 DRUGMATRIX: Opiate kappa (OP2, KOP) radioligand binding (ligand: [3H] Diprenorphine) [AID625162, Type: other]Kappa-type opioid receptor [gi:116242691]
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47
[SID160703999]
IC50 DRUGMATRIX: Insulin radioligand binding (ligand: [125I] Insulin) [AID625273, Type: other]Insulin receptor [gi:124531]
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48
[SID160703999]
IC50 DRUGMATRIX: Protein Tyrosine Kinase, Fyn enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625185, Type: other]Tyrosine-protein kinase Fyn [gi:125370]
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49
[SID160703999]
IC50 DRUGMATRIX: Protein Tyrosine Kinase, LCK enzyme inhibition (substrate: Poly(Glu:Tyr)) [AID625187, Type: other]Tyrosine-protein kinase Lck [gi:125474]
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50
[SID160703999]
IC50 DRUGMATRIX: Lipoxygenase 15-LO enzyme inhibition (substrate: Linoleic acid) [AID625146, Type: other]Arachidonate 15-lipoxygenase [gi:126397]
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