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Glycyrrhizic Acid (CID 14982) - Compound BioActivity Data
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BioActivity Outcomes:
Active(10)
 
 
Inactive(198)
 
 
Inconclusive(23)
 
 
Unspecified(208)
 
 
Top Targets:
NR LBD ER(23)
 
 
 
 
NR LBD AR(22)
 
 
 
 
 
7TM GPCR Srsx(19)
 
 
 
7TM GPCR Srx(17)
 
 
p450(14)
 
 
 
 
BioAssay Types:
Confirmatory(282)
 
 
 
 
 
Literature(82)
 
 
 
Summary(54)
 
 
 
 
Screening(4)
 
 
BioActivity Types:
Potency(207)
 
 
 
 
IC50(125)
 
 
 
Ki(5)
 
 
AC50(3)
 
 
EC50(3)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 314    Data Row: 439   Total Pages: 22   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID160703999]
EC50 0.001Inhibition of human 11beta-HSD2 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA [AID657950, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 2 [gi:30316367]
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2
[SID160703999]
IC50 0.001Inhibition of human microsomal 11beta-HSD2 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay [AID433139, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 2 [gi:30316367]
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3
[SID160703999]
EC50 0.008Inhibition of mouse 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA [AID657949, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:1706408]
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4
[SID160703999]
IC50 0.008Inhibition of mouse microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay [AID433138, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:1706408]
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5
[SID160703999]
IC50 0.01Inhibition of human microsomal 11beta-HSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone to [3H]cortisol by scintillation proximity assay [AID433137, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:118569]
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6
[SID160703999]
EC50 0.01Inhibition of human 11beta-HSD1 expressed in HEK293 cells assessed as [3H]cortisol production after 60 mins by SPA [AID657948, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:118569]
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7
[SID160703999]
IC50 0.015Inhibition of mouse liver microsome 11betaHSD1 expressed in HEK293 cells assessed as conversion of [3H]cortisone into [3H]cortisol by scintillation proximity assay [AID431046, Type: Literature]Corticosteroid 11-beta-dehydrogenase isozyme 1 [gi:1706408]
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8
[SID144205073]
Potency-Replicate_1 13.3332qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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9
[SID144206976]
Potency-Replicate_1 13.3332qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743040, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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10
[SID144205073]
Ratio Potency (uM) 17.9333qHTS assay to identify small molecule agonists of the glucocorticoid receptor (GR) signaling pathway: Summary [AID720719, Type: summary]glucocorticoid receptor [Homo sapiens] [gi:311348376]
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11
[SID160703999]
Ki 0.84TP_TRANSPORTER: inhibition of DNP-SG uptake in bile canalicular membrane vesicles from SD rat [AID681175, Type: Literature]Canalicular multispecific organic anion transporter 1 [gi:3219824]
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12
[SID160703999]
Ki 1.91TP_TRANSPORTER: inhibition of SN-38 uptake in bile canalicular membrane vesicles from SD rat [AID679806, Type: Literature]Canalicular multispecific organic anion transporter 1 [gi:3219824]
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13
[SID160703999]
Ki 6.1TP_TRANSPORTER: inhibition of E1S uptake in Xenopus laevis oocytes [AID681650, Type: Literature]Solute carrier organic anion transporter family member 1B2 [gi:317373278]
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14
[SID160703999]
Ki 12.5TP_TRANSPORTER: inhibition of BSP uptake in Xenopus laevis oocytes [AID680384, Type: Literature]Solute carrier organic anion transporter family member 1B3 [gi:27734563]
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15
[SID160703999]
Ki 15.9TP_TRANSPORTER: inhibition of E1S uptake in Xenopus laevis oocytes [AID680745, Type: Literature]Solute carrier organic anion transporter family member 1B1 [gi:12643959]
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16
[SID160703999]
ED50 70Inhibition of HMGB1 in mouse RAW264.7 cells assessed as LPS-induced TNFalpha release treated for 2 hrs prior to LPS-challenge measured after 16 hrs by ELISA [AID723646, Type: Literature]High mobility group protein B1 [gi:52783747]
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17
[SID160703999]
IC50 82.4Hepatoprotective activity in mouse hepatocytes assessed inhibition of D-galactosamine/TNFalpha-induced cell death dosed administered before 30 mins of TNFalpha challenge measured after 18 hrs [AID359488, Type: Literature]
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18
[SID160703999]
IC50 100Inhibition of human recombinant PTP1B [AID265377, Type: Literature]Tyrosine-protein phosphatase non-receptor type 1 [gi:131467]
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19
[SID160703999]
Kd 150Binding affinity to HMGB1 (unknown origin) [AID723645, Type: Literature]High mobility group protein B1 [gi:123369]
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20
[SID160703999]
IC50 200Hepatoprotective activity against D-galactosamine/TNFalpha-induced cell death in primary cultured mouse hepatocytes treated for 30 mins before TNFalpha challenge measured after 18 hrs by MTT assay [AID359156, Type: Literature]
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