2,4-Dinitrophenol (CID 1493) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(15)
 
 
Inactive(563)
 
 
Inconclusive(29)
 
 
Unspecified(19)
 
 
Top Targets:
7TM GPCR Srx(9)
 
 
NR LBD TR(6)
 
 
 
7TM GPCR Srsx(5)
 
 
NR LBD PPAR(5)
 
 
 
TRP 2(5)
 
 
BioAssay Types:
Screening(314)
 
 
 
 
Confirmatory(258)
 
 
 
 
 
Literature(28)
 
 
 
 
BioActivity Types:
Potency(203)
 
 
 
 
 
IC50(18)
 
 
 
 
EC50(5)
 
 
 
Ki(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 592    Data Row: 626   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID47193722]
Potency 2.3053qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. [AID588397, Type: confirmatory]
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2
[SID17389906]
Potency 6.6824qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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3
[SID17389906]
Potency 6.6824qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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4
[SID17389906]
Potency 6.6824qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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5
[SID17389906]
Potency 6.6824qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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6
[SID17389906]
Potency 6.6824qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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7
[SID103173306]
IC50 15.851Cytotoxicity against human MIA PaCa2 cells after 4 hrs by MTT assay [AID303043, Type: Literature]
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8
[SID17389906]
Potency 21.1317qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 1 hr assay [AID651754, Type: confirmatory]
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9
[SID103173306]
IC50 22.101Cytotoxicity against human MIA PaCa2 cells after 72 hrs by MTT assay [AID303044, Type: Literature]
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10
[SID17389906]
Potency 22.3872VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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11
[SID17389906]
Potency 37.578qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 5 hr assay [AID651755, Type: confirmatory]
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12
[SID17389906]
Potency 66.8242qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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13
[SID17389906]
Potency 66.8242qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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14
[SID17389906]
Potency 66.8242qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
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15
[SID17389906]
Potency 66.8242qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]NFE2L2 gene product [Homo sapiens] [gi:20149576]
View
16
[SID85787987]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of MITF [AID2240, Type: screening]microphthalmia-associated transcription factor isoform 1 [Homo sapiens] [gi:38156699]
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17
[SID85787987]
 Luminescence Cell-Based Primary HTS to Identify Inhibitors of MITF [AID2240, Type: screening]microphthalmia-associated transcription factor isoform 1 [Homo sapiens] [gi:38156699]
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18
[SID47193722]
 FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID485270, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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19
[SID47193722]
 FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID485270, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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20
[SID103173306]
 Disruption of bacterial membrane permeability in Bacillus subtilis BD54 using DiSC3 fluorescent dye staining based fluorimetric assay [AID580626, Type: Literature]
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21
[SID103173306]
 Inactivation of Pseudomonas putida PAW340 biofilms assessed as decrease in heat production at 0.5 mM by Chip calorimetry [AID584825, Type: Literature]
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22
[SID103173306]
 Inactivation of Pseudomonas putida PAW340 biofilms assessed as decrease in ATP content at 0.5 mM by Chip calorimetry [AID584826, Type: Literature]
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23
[SID48414898]
 DSSTox (EPAFHM) EPA Fathead Minnow Acute Toxicity [AID1188, Type: other]
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24
[SID47193722]
 Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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25
[SID103173306]
Ki 50Inhibition of Escherichia coli HisG [AID390924, Type: Literature]
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26
[SID103173306]
IC50 98Antiproliferative activity against human HL60 cell line [AID267573, Type: Literature]
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27
[SID103173306]
EC50 200Cell death rescue in rat striatal neuron N548 mutant cells [AID329496, Type: Literature]
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28
[SID103173306]
EC50 700Cell death rescue of ASH neuronal cells in Caenorhabditis elegans Huntington's disease model [AID329499, Type: Literature]
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29
[SID103173306]
IC50 1000Uncoupler concentration that reduced the respiratory control index by 50% ofcoupled rat liver mitochondria [AID195261, Type: Literature]
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30
[SID103173306]
EC50 1250Cell death rescue of neuronal cells in drosophila Huntington's disease model [AID329522, Type: Literature]
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31
[SID103173306]
 Toxicity in rat striatal neuronal N548 mutant cells [AID329523, Type: Literature]
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32
[SID103173306]
 Cell death rescue in rat striatal neuron N548 mutant cells relative to rotenone [AID329524, Type: Literature]
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33
[SID103173306]
 Activation of AMPKalpha in rat L6 cells assessed as ATP concentration per mg of protein at 5 mM after 10 mins in presence of 23 mM D-glucose [AID389779, Type: Literature]
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34
[SID103173306]
EC50 Toxicity in Caenorhabditis elegans Huntington's disease model [AID329497, Type: Literature]
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35
[SID103173306]
 Toxicity in drosophila Huntington's disease model [AID329498, Type: Literature]
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36
[SID103173306]
 Partition coefficient (logP) (HPLC) [AID19687, Type: Literature]
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37
[SID103173306]
 The pKa value in aqueous solution. [AID25078, Type: Literature]
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38
[SID103173306]
 Ability to bind to monoclonal antibody IgE (Lb4), expressed as association constant (LogKA) [AID127482, Type: Literature]
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39
[SID103173306]
 Inactivation of Pseudomonas putida PAW340 biofilms assessed as decrease in heat production at 0.5 mM within 1 hr by Chip calorimetry [AID584833, Type: Literature]
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40
[SID103173306]
 Literature-mined public compounds from Greene et al multi-species hepatotoxicity modelling dataset [AID588209, Type: Literature]
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41
[SID103173306]
 Human drug-induced liver injury (DILI) modelling dataset from Ekins et al [AID588210, Type: Literature]
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42
[SID17389906]
 qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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43
[SID47193722]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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44
[SID47193722]
Potency qHTS for Inhibitors of Human Acid Sphingomyelinase Assay: Native Substrate [AID624178, Type: confirmatory]acid sphingomyelinase [Homo sapiens] [gi:179095]
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45
[SID47193722]
Potency 0.2818A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]GMNN gene product [Homo sapiens] [gi:7705682]
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46
[SID17389906]
Potency 7.9433qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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47
[SID17389906]
Potency 7.9433qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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48
[SID17389906]
Potency 7.9433qHTS Assay for Agonists of the Thyroid Stimulating Hormone Receptor: Activators of Intracellular cAMP Concentrations in Parental HEK 293 [AID938, Type: confirmatory]thyroid stimulating hormone receptor [Homo sapiens] [gi:38016895]
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49
[SID26747391]
Potency 10qHTS Assay for Compounds that Induce Erasure of Genomic Imprints [AID1948, Type: confirmatory]
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50
[SID26747391]
Potency 11.2202qHTS Assay for Enhancers of SMN2 Splice Variant Expression [AID1458, Type: confirmatory]survival motor neuron protein isoform d [Homo sapiens] [gi:10937869]
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