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2,4-Dinitrophenol (CID 1493) - Compound BioActivity Data
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BioActivity Outcomes:
Active(42)
 
 
Inactive(718)
 
 
Inconclusive(107)
 
 
Unspecified(20)
 
 
Top Targets:
NR LBD PPAR(21)
 
 
 
 
NR LBD ER(16)
 
 
 
NR LBD AR(16)
 
 
 
 
7TM GPCR Srx(14)
 
 
 
NR LBD TR(12)
 
 
 
BioAssay Types:
Confirmatory(418)
 
 
 
 
 
Screening(365)
 
 
 
 
Summary(48)
 
 
 
 
Literature(29)
 
 
 
 
BioActivity Types:
Potency(395)
 
 
 
 
 
IC50(18)
 
 
 
 
EC50(5)
 
 
 
Ki(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 723    Data Row: 887   Total Pages: 18   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144210350]
Potency-Replicate_1 0.0977qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway - cell viability counter screen [AID743194, Type: confirmatory]
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2
[SID144210350]
Potency-Replicate_1 0.5448qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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3
[SID144208660]
Potency-Replicate_1 0.6887qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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4
[SID144210350]
Ratio Potency (uM) 1.00676qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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5
[SID144208660]
Potency-Replicate_1 1.386qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743218, Type: confirmatory]
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6
[SID47193722]
Potency 2.3053qHTS of small molecules that selectively kill Giardia lamblia: Hit Validation. [AID588397, Type: confirmatory]
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7
[SID144208660]
Ratio Potency (uM) 2.96043qHTS assay for small molecule disruptors of the mitochondrial membrane potential: Summary [AID720637, Type: summary]
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8
[SID17389906]
Potency 6.6824qHTS assay for small molecule antagonists of the retinoid-related orphan receptor gamma (ROR-gamma) signaling pathway [AID651802, Type: confirmatory]Nuclear receptor ROR-gamma [gi:49066040]
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9
[SID144210350]
Potency-Replicate_1 10.8707qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
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10
[SID144208660]
Potency-Replicate_1 10.915qHTS assay for small molecule disruptors of the mitochondrial membrane potential - cell viability [AID720634, Type: confirmatory]
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11
[SID103173306]
IC50 15.851Cytotoxicity against human MIA PaCa2 cells after 4 hrs by MTT assay [AID303043, Type: Literature]
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12
[SID17389906]
Potency 21.1317qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 1 hr assay [AID651754, Type: confirmatory]
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13
[SID144210350]
Ratio Potency (uM) 21.6899qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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14
[SID103173306]
IC50 22.101Cytotoxicity against human MIA PaCa2 cells after 72 hrs by MTT assay [AID303044, Type: Literature]
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15
[SID17389906]
Potency 22.3872VP16 counterscreen qHTS for inhibitors of ROR gamma transcriptional activity [AID2546, Type: confirmatory]nuclear receptor ROR-gamma [Mus musculus] [gi:188536040]
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16
[SID144208660]
Potency-Replicate_1 24.4355qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway [AID743085, Type: confirmatory]aryl hydrocarbon receptor [Homo sapiens] [gi:51095037]
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17
[SID144210350]
Potency-Replicate_1 27.306qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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18
[SID144208660]
Potency-Replicate_1 27.4171qHTS assay for small molecules that induce genotoxicity in human embryonic kidney cells expressing luciferase-tagged ATAD5 - cell viability [AID651634, Type: confirmatory]
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19
[SID144210350]
Potency-Replicate_1 30.6379qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID743202, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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20
[SID144210350]
Potency-Replicate_1 30.6379qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line - cell viability counter screen [AID743081, Type: confirmatory]
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21
[SID144208660]
Potency-Replicate_1 30.7625qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line - cell viability counter screen [AID743041, Type: confirmatory]
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22
[SID144208660]
Potency-Replicate_1 30.7625qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line - cell viability counter screen [AID743081, Type: confirmatory]
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23
[SID17389906]
Potency 37.578qHTS assay for small molecule disruptors of the mitochondrial membrane potential - 5 hr assay [AID651755, Type: confirmatory]
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24
[SID144208660]
Potency-Replicate_1 38.7277qHTS assay to identify small molecule that activate the aryl hydrocarbon receptor (AhR) signaling pathway - cell viability counter screen [AID743086, Type: confirmatory]
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25
[SID144208660]
Potency-Replicate_1 48.7553qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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26
[SID144208660]
Potency-Replicate_1 48.7553qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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27
[SID144210350]
Potency-Replicate_1 54.4827qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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28
[SID144208660]
Potency-Replicate_1 54.7044qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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29
[SID144208660]
Potency-Replicate_1 54.7044qHTS assay to identify aromatase inhibitors - cell viability counter screen [AID743084, Type: confirmatory]
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30
[SID144208660]
Potency-Replicate_1 55.1764qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway [AID743191, Type: confirmatory]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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31
[SID144210350]
Potency-Replicate_1 61.1306qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line - cell viability counter screen [AID743041, Type: confirmatory]
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32
[SID144210350]
Potency-Replicate_1 61.1306qHTS assay to identify small molecule antagonists of the thyroid receptor (TR) signaling pathway - cell viability counter screen [AID743064, Type: confirmatory]
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33
[SID144210350]
Potency-Replicate_1 61.1306qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line [AID743042, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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34
[SID17389906]
Potency 66.8242qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway [AID651741, Type: confirmatory]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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35
[SID144210350]
Potency-Replicate_1 68.5896qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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36
[SID103173306]
Disruption of bacterial membrane permeability in Bacillus subtilis BD54 using DiSC3 fluorescent dye staining based fluorimetric assay [AID580626, Type: Literature]
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37
[SID103173306]
Inactivation of Pseudomonas putida PAW340 biofilms assessed as decrease in heat production at 0.5 mM by Chip calorimetry [AID584825, Type: Literature]
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38
[SID103173306]
Inactivation of Pseudomonas putida PAW340 biofilms assessed as decrease in ATP content at 0.5 mM by Chip calorimetry [AID584826, Type: Literature]
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39
[SID47193722]
Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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40
[SID48414898]
DSSTox (EPAFHM) EPA Fathead Minnow Acute Toxicity [AID1188, Type: other]
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41
[SID85787987]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of MITF [AID2240, Type: screening]microphthalmia-associated transcription factor isoform 1 [Homo sapiens] [gi:38156699]
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42
[SID47193722]
FRET-based cell-based primary high throughput screening assay to identify antagonists of the orexin 1 receptor (OX1R; HCRTR1) [AID485270, Type: screening]orexin receptor type 1 [Homo sapiens] [gi:222080095]
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43
[SID103173306]
Ki 50Inhibition of Escherichia coli HisG [AID390924, Type: Literature]
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44
[SID103173306]
IC50 98Antiproliferative activity against human HL60 cell line [AID267573, Type: Literature]
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45
[SID103173306]
EC50 200Cell death rescue in rat striatal neuron N548 mutant cells [AID329496, Type: Literature]
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46
[SID103173306]
EC50 700Cell death rescue of ASH neuronal cells in Caenorhabditis elegans Huntington's disease model [AID329499, Type: Literature]
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47
[SID103173306]
IC50 1000Uncoupler concentration that reduced the respiratory control index by 50% ofcoupled rat liver mitochondria [AID195261, Type: Literature]
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48
[SID103173306]
EC50 1250Cell death rescue of neuronal cells in drosophila Huntington's disease model [AID329522, Type: Literature]
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49
[SID103173306]
Toxicity in rat striatal neuronal N548 mutant cells [AID329523, Type: Literature]
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50
[SID103173306]
Cell death rescue in rat striatal neuron N548 mutant cells relative to rotenone [AID329524, Type: Literature]
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