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1-(4-hexylphenyl)prop-2-en-1-one (CID 14899645) - Compound BioActivity Data
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BioActivity Outcomes:
Active(12)
 
 
Inactive(82)
 
 
Inconclusive(9)
 
 
Unspecified(2)
 
 
Top Targets:
NR LBD TR(4)
 
 
 
Pyr redox dim(4)
 
 
 
7TM GPCR Srx(4)
 
 
 
PIKKc TOR(4)
 
 
Hexokinase 2(3)
 
 
BioAssay Types:
Confirmatory(90)
 
 
 
 
Literature(10)
 
 
 
 
Screening(5)
 
 
BioActivity Types:
Potency(91)
 
 
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 90    Data Row: 105   Total Pages: 3   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103541168]
IC50 1.5Displacement of labeled SRC2-2 from human TRbeta expressed in BL21 (DE3) cells FP assay [AID302460, Type: Literature]Thyroid hormone receptor beta [gi:586092]
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2
[SID90341136]
Potency 2.6679Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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3
[SID29217563]
Potency 4.4668Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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4
[SID103541168]
LD50 4.5Cytotoxicity against human ARO cells after 48 hrs by MTS assay [AID302462, Type: Literature]
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5
[SID103541168]
LD50 10.1Cytotoxicity against human U2OS cells after 48 hrs by MTS assay [AID302463, Type: Literature]
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6
[SID90341136]
Potency 11.2202qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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7
[SID90341136]
Potency 12.5893qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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8
[SID90341136]
Potency 15.003qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) [AID488773, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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9
[SID103541168]
IC50 28.1Displacement of labeled SRC2-2 from human TRalpha by FP assay [AID302459, Type: Literature]Thyroid hormone receptor alpha [gi:135705]
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10
[SID90341136]
Potency 39.8107Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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11
[SID90341136]
Potency 56.2341Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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12
[SID103541168]
Solubility in PBS [AID302464, Type: Literature]
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13
[SID103541168]
Permeability across artificial membrane at pH 7.4 by PAMPA assay [AID302465, Type: Literature]
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14
[SID103541168]
Selectivity ratio of IC50 for TRBeta to IC50 for TRalpha [AID302461, Type: Literature]
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15
[SID90341136]
Potency 5.6234qHTS for Inhibitors of Glutaminase (GLS): LOPAC Validation [AID624146, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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16
[SID90341136]
Potency 7.9433qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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17
[SID90341136]
Potency 16.3601qHTS for compounds that reverse cellular toxicity of Amyloid beta (A-beta) peptide in yeast: LOPAC Validation Assay [AID720559, Type: confirmatory]Amyloid beta A4 protein [gi:112927]
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18
[SID90341136]
Potency 29.0929qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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19
[SID90341136]
Potency qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay [AID588349, Type: confirmatory]
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20
[SID29217563]
Potency qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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21
[SID29217563]
Potency qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia [AID1477, Type: confirmatory]
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22
[SID90341136]
Potency Nrf2 qHTS screen for inhibitors: Validation [AID493153, Type: confirmatory] [geneid:4780]
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23
[SID29217563]
Potency qHTS for Inhibitors of binding or entry into cells for Marburg Virus [AID720532, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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24
[SID90341136]
Potency qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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25
[SID29217563]
Potency qHTS for inhibitors of binding or entry into cells for Marburg Virus [AID540276, Type: confirmatory]gene 4 small orf - Marburg virus [gi:420597]
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26
[SID29217563]
Potency qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease [AID2101, Type: confirmatory]glucocerebrosidase [Homo sapiens] [gi:496369]
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27
[SID90341136]
Potency qHTS of alpha-syn Inhibitors [AID652106, Type: confirmatory]Alpha-synuclein [gi:586067]
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28
[SID90341136]
Potency qHTS assay for inhibitors of recombinant human GCK-GKRP interaction: Diaphorase-coupled assay [AID743205, Type: confirmatory]glucokinase isoform 1 [Homo sapiens] [gi:4503951]
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29
[SID90341136]
Potency qHTS assay for inhibitors of recombinant human GCK-GKRP interaction: ADP-Glo assay [AID743206, Type: confirmatory]glucokinase isoform 1 [Homo sapiens] [gi:4503951]
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30
[SID90341136]
Potency qHTS assay for inhibitors of recombinant human GCK-GKRP interaction: HTRF assay [AID743207, Type: confirmatory]glucokinase isoform 1 [Homo sapiens] [gi:4503951]
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31
[SID29217563]
Potency qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein isoform 1 [Homo sapiens] [gi:4557365]
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32
[SID90341136]
Potency qHTS Validation Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1) [AID488816, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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33
[SID90341136]
Potency qHTS Assay for the Inhibitors of Human Flap endonuclease 1 (FEN1). [AID588795, Type: confirmatory]flap endonuclease 1 [Homo sapiens] [gi:4758356]
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34
[SID90341136]
Potency qHTS Assay for Rab9 Promoter Activators [AID485297, Type: confirmatory]ras-related protein Rab-9A [Homo sapiens] [gi:4759012]
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35
[SID90341136]
Potency Cytometric Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells [AID2660, Type: confirmatory]serine/threonine-protein kinase mTOR [Homo sapiens] [gi:4826730]
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36
[SID90341136]
Potency High Content Imaging Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF (Tsc2-/-, p53-/-) Cells [AID2666, Type: confirmatory]serine/threonine-protein kinase mTOR [Homo sapiens] [gi:4826730]
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37
[SID90341136]
Potency High Content Imaging Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF Cells [AID2667, Type: confirmatory]serine/threonine-protein kinase mTOR [Homo sapiens] [gi:4826730]
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38
[SID90341136]
Potency Cytometry Cell-Based qHTS for Inhibitors of the mTORC1 Signaling Pathway in MEF cells [AID2668, Type: confirmatory]serine/threonine-protein kinase mTOR [Homo sapiens] [gi:4826730]
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39
[SID90341136]
Potency qHTS Validation Assay to Find Inhibitors of Pin1 [AID504536, Type: confirmatory]peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 [Homo sapiens] [gi:5453898]
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40
[SID90341136]
Potency qHTS Validation Assay for Iinhibitors of HIV-1 Budding by Blocking the Interaction of PTAP/TSG101 [AID485342, Type: confirmatory]tumor susceptibility gene 101 protein [Homo sapiens] [gi:5454140]
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41
[SID90341136]
Potency qHTS for Inhibitors of Cell Surface uPA Generation: Validation Assay [AID493164, Type: confirmatory]urokinase-type plasminogen activator precursor [Mus musculus] [gi:6679377]
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42
[SID29217563]
Potency qHTS Assay for Inhibitors of the Human Apurinic/apyrimidinic Endonuclease 1 (APE1) [AID2517, Type: confirmatory]Chain A, Human Ape1 Endonuclease With Bound Abasic Dna And Mn2+ Ion [gi:6980812]
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43
[SID90341136]
Potency qHTS for Inhibitors of Cell Surface uPA Generation: Validation Assay [AID493164, Type: confirmatory]urokinase plasminogen activator surface receptor precursor [Mus musculus] [gi:7242179]
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44
[SID29217563]
qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia: Coupling assay counterscreen [AID2472, Type: screening]glyceraldehyde-3-phosphate dehydrogenase isoform 1 [Homo sapiens] [gi:7669492]
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45
[SID29217563]
Potency qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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46
[SID90341136]
Potency qHTS for Inhibitors of Polymerase Kappa [AID588579, Type: confirmatory]DNA polymerase kappa [Homo sapiens] [gi:7705344]
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47
[SID90341136]
Potency qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) [AID488772, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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48
[SID29217563]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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49
[SID29217563]
Potency qHTS Assay for Inhibitors of Fructose-1,6-bisphosphate Aldolase from Giardia Lamblia [AID2451, Type: confirmatory]Chain A, Structure Of Giardia Fructose-1,6-biphosphate Aldolase In Complex With Phosphoglycolohydroxamate [gi:122920737]
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50
[SID29217563]
Potency qHTS Assay for Inhibitors of GCN5L2 [AID504327, Type: confirmatory]histone acetyltransferase KAT2A [Homo sapiens] [gi:153791535]
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