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1-(4-hexylphenyl)prop-2-en-1-one (CID 14899645) - Compound BioActivity Data
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BioActivity Outcomes:
Active(12)
 
 
Inactive(83)
 
 
Inconclusive(9)
 
 
Unspecified(2)
 
 
Top Targets:
NR LBD TR(4)
 
 
 
Pyr redox dim(4)
 
 
 
7TM GPCR Srx(4)
 
 
 
PIKKc TOR(4)
 
 
Hexokinase 2(3)
 
 
BioAssay Types:
Confirmatory(91)
 
 
 
 
Literature(10)
 
 
 
 
Screening(5)
 
 
BioActivity Types:
Potency(92)
 
 
 
 
IC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 91    Data Row: 106   Total Pages: 6   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103541168]
IC50 1.5Displacement of labeled SRC2-2 from human TRbeta expressed in BL21 (DE3) cells FP assay [AID302460, Type: Literature]Thyroid hormone receptor beta [gi:586092]
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2
[SID90341136]
Potency 2.6679Inhibitors of Regulator of G Protein Signaling (RGS) 4: qHTS [AID504845, Type: confirmatory]regulator of G-protein signaling 4 [Homo sapiens] [gi:86301163]
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3
[SID29217563]
Potency 4.4668Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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4
[SID103541168]
LD50 4.5Cytotoxicity against human ARO cells after 48 hrs by MTS assay [AID302462, Type: Literature]
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5
[SID103541168]
LD50 10.1Cytotoxicity against human U2OS cells after 48 hrs by MTS assay [AID302463, Type: Literature]
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6
[SID90341136]
Potency 11.2202qHTS Assay for Inhibitors of Histone Lysine Methyltransferase G9a [AID504332, Type: confirmatory]euchromatic histone-lysine N-methyltransferase 2 [Homo sapiens] [gi:168985070]
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7
[SID90341136]
Potency 12.5893qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588453, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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8
[SID90341136]
Potency 15.003qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1) [AID488773, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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9
[SID103541168]
IC50 28.1Displacement of labeled SRC2-2 from human TRalpha by FP assay [AID302459, Type: Literature]Thyroid hormone receptor alpha [gi:135705]
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10
[SID90341136]
Potency 39.8107Inhibitors of the vitamin D receptor (VDR): qHTS [AID504847, Type: confirmatory]vitamin D3 receptor isoform VDRA [Homo sapiens] [gi:63054845]
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11
[SID90341136]
Potency 56.2341Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein [Homo sapiens] [gi:118600387]
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12
[SID103541168]
Solubility in PBS [AID302464, Type: Literature]
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13
[SID103541168]
Permeability across artificial membrane at pH 7.4 by PAMPA assay [AID302465, Type: Literature]
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14
[SID103541168]
Selectivity ratio of IC50 for TRBeta to IC50 for TRalpha [AID302461, Type: Literature]
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15
[SID90341136]
Potency 5.6234qHTS for Inhibitors of Glutaminase (GLS): LOPAC Validation [AID624146, Type: confirmatory]GLS protein [Homo sapiens] [gi:71051501]
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16
[SID90341136]
Potency 7.9433qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS [AID588456, Type: confirmatory]thioredoxin reductase [Rattus norvegicus] [gi:8659577]
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17
[SID90341136]
Potency 16.3601qHTS for compounds that reverse cellular toxicity of Amyloid beta (A-beta) peptide in yeast: LOPAC Validation Assay [AID720559, Type: confirmatory]Amyloid beta A4 protein [gi:112927]
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18
[SID90341136]
Potency 29.0929qHTS Assay for Small Molecule Inhibitors of Mitochondrial Division or Activators of Mitochondrial Fusion [AID485298, Type: confirmatory]
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19
[SID90341136]
Potency qHTS for Inhibitors of ATXN expression: Validation of Cytotoxic Assay [AID588349, Type: confirmatory]
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20
[SID29217563]
Potency qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID720533, Type: confirmatory]
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