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MLS002702096 (CID 148870) - Compound BioActivity Data
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BioActivity Outcomes:
Active(80)
 
 
Inactive(297)
 
 
Inconclusive(22)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(12)
 
 
7TM GPCR Srsx(11)
 
 
SRC-1(5)
 
 
 
ABCC CFTR1(4)
 
 
RasGEF(4)
 
 
BioAssay Types:
Screening(220)
 
 
 
 
Confirmatory(155)
 
 
 
 
 
Literature(3)
 
 
BioActivity Types:
Potency(78)
 
 
 
 
 
IC50(11)
 
 
 
 
AC50(5)
 
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 369    Data Row: 400   Total Pages: 8   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID92764822]
Potency 0.1636qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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2
[SID92764822]
Potency 0.1636qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID92764822]
IC50 0.44268Luminescence-based cell-based high throughput dose response assay for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1) [AID602235, Type: confirmatory]nuclear receptor coactivator 1 isoform 1 [Homo sapiens] [gi:22538455]
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4
[SID92764822]
IC50 0.52517Counterscreen for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1) [AID602168, Type: confirmatory]nuclear receptor coactivator 1 isoform 1 [Homo sapiens] [gi:22538455]
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5
[SID92764822]
IC50 0.60521Luminescence-based cell-based high throughput dose response assay for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3) [AID602166, Type: confirmatory]nuclear receptor coactivator 3 isoform a [Homo sapiens] [gi:32307126]
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6
[SID92764822]
Potency 0.7079qHTS for Inhibitors of binding or entry into cells for Lassa Virus [AID540256, Type: confirmatory]
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7
[SID92764822]
IC50 1.008Counterscreen for inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1): Luminescence-based cell-based high throughput dose response assay to identify inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3) [AID602234, Type: confirmatory]nuclear receptor coactivator 3 isoform a [Homo sapiens] [gi:32307126]
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8
[SID92764822]
AC50_uM 1.03Shn3: Dual-Go Shn3RL cells Measured in Cell-Based System Using Plate Reader - 2134-02_Inhibitor_Dose_CherryPick_Activity [AID624133, Type: confirmatory]
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9
[SID92764822]
AC50_uM 3.15FRET-based HTS for detection of RAD52 Inhibitors Measured in Biochemical System Using Plate Reader - 7018-01_Inhibitor_Dose_CherryPick_Activity [AID652116, Type: confirmatory]DNA repair protein RAD52 homolog [Homo sapiens] [gi:109637798]
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10
[SID92764822]
EC50_MICROM 3.38Dose Response of Inhibitors of Lytic Granule Exocytosis with compounds from CherryPick01 [AID652101, Type: confirmatory]
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11
[SID92764822]
AC50_uM 3.39Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_Dose_CherryPick_Activity [AID624132, Type: confirmatory]
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12
[SID92764822]
Potency 7.3078A quantitative high throughput screen for small molecules that induce DNA re-replication in SW480 colon adenocarcinoma cells. [AID624297, Type: confirmatory]geminin [Homo sapiens] [gi:7705682]
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13
[SID92764822]
Potency 10qHTS for Inhibitors of TGF-b [AID588855, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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14
[SID92764822]
Potency 11.9173qHTS for Inhibitors of ATXN expression [AID651635, Type: confirmatory]ataxin-2 [Homo sapiens] [gi:171543895]
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15
[SID92764822]
Potency 12.9953qHTS for Inhibitors of TGF-b: CCL64 Cells Orthogonal Assay for Cherry Picks [AID720536, Type: confirmatory]Smad3 [Homo sapiens] [gi:18418623]
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16
[SID92764822]
Potency 14.581qHTS for Inhibitors of TGF-b: Cytotox Counterscreen for Cherry Picks [AID720535, Type: confirmatory]
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17
[SID92764822]
AC50_uM 20.08Shn3: Cytotox assay Measured in Cell-Based System Using Plate Reader - 2134-03_Inhibitor_Dose_CherryPick_Activity [AID624134, Type: confirmatory]
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18
[SID92764822]
Potency 39.8107qHTS Assay for Inhibitors of JMJD2A-Tudor Domain [AID504339, Type: confirmatory]Chain A, Jmjd2a Tandem Tudor Domains In Complex With A Trimethylated Histone H4-K20 Peptide [gi:162330054]
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19
[SID92764822]
Luminescence-based cell-based primary high throughput screening assay to identify inhibitors of the Steroid Receptor Coactivator 1 (SRC1; NCOA1) [AID588354, Type: screening]nuclear receptor coactivator 1 isoform 1 [Homo sapiens] [gi:22538455]
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20
[SID92764822]
Luminescence-based cell-based high throughput confirmation assay for inhibitors of the Steroid Receptor Coactivator 3 (SRC3; NCOA3) [AID588792, Type: screening]nuclear receptor coactivator 3 isoform a [Homo sapiens] [gi:32307126]
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21
[SID92764822]
Luminescence-based cell-based primary high throughput confirmation assay to identify activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM) [AID652260, Type: screening]SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, isoform CRA_a [Homo sapiens] [gi:119579215]
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22
[SID92764822]
Luminescence-based cell-based primary high throughput screening assay to identify activators of the function of SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, BRM) [AID652017, Type: screening]SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2, isoform CRA_a [Homo sapiens] [gi:119579215]
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23
[SID92764822]
Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_SinglePoint_HTS_Activity_Set2 [AID588674, Type: screening]
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24
[SID92764822]
Inhibition of granule serine esterase secretion with compounds from CherryPick01 [AID720662, Type: screening]
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25
[SID92764822]
Inhibition of Exocytosis of Lytic Granulocytes as measured by LAMP-1 externalization with compounds from CherryPick01 [AID720663, Type: screening]
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26
[SID92764822]
Inhibition of Calcium signaling with compounds from CherryPick01 [AID720670, Type: screening]
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27
[SID92764822]
Flow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with MLPCN Compound Library [AID651702, Type: screening]
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28
[SID135644]
NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line [AID1, Type: confirmatory]
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29
[SID135644]
NCI human tumor cell line growth inhibition assay. Data for the NCI-H460 Non-Small Cell Lung cell line [AID7, Type: confirmatory]
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30
[SID135644]
NCI human tumor cell line growth inhibition assay. Data for the HOP-62 Non-Small Cell Lung cell line [AID9, Type: confirmatory]
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31
[SID135644]
NCI human tumor cell line growth inhibition assay. Data for the LOX IMVI Melanoma cell line [AID23, Type: confirmatory]
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32
[SID135644]
NCI human tumor cell line growth inhibition assay. Data for the M14 Melanoma cell line [AID25, Type: confirmatory]
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33
[SID135644]
NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line [AID29, Type: confirmatory]
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34
[SID135644]
NCI human tumor cell line growth inhibition assay. Data for the UACC-62 Melanoma cell line [AID31, Type: confirmatory]
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35
[SID135644]
NCI human tumor cell line growth inhibition assay. Data for the NCI-H522 Non-Small Cell Lung cell line [AID15, Type: confirmatory]
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36
[SID135644]
NCI human tumor cell line growth inhibition assay. Data for the A549/ATCC Non-Small Cell Lung cell line [AID19, Type: confirmatory]
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37
[SID135644]
NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-28 Melanoma cell line [AID39, Type: confirmatory]
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38
[SID135644]
NCI human tumor cell line growth inhibition assay. Data for the SNB-19 Central Nervous System cell line [AID53, Type: confirmatory]
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39
[SID135644]
NCI human tumor cell line growth inhibition assay. Data for the SNB-75 Central Nervous System cell line [AID55, Type: confirmatory]
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40
[SID135644]
NCI human tumor cell line growth inhibition assay. Data for the U251 Central Nervous System cell line [AID59, Type: confirmatory]
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41
[SID135644]
NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line [AID43, Type: confirmatory]
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42
[SID135644]
NCI human tumor cell line growth inhibition assay. Data for the SF-268 Central Nervous System cell line [AID45, Type: confirmatory]
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43
[SID135644]
NCI human tumor cell line growth inhibition assay. Data for the SF-295 Central Nervous System cell line [AID47, Type: confirmatory]
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44
[SID135644]
NCI human tumor cell line growth inhibition assay. Data for the MCF7 Breast cell line [AID83, Type: confirmatory]
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45
[SID135644]
NCI human tumor cell line growth inhibition assay. Data for the 786-0 Renal cell line [AID137, Type: confirmatory]
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46
[SID135644]
NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line [AID139, Type: confirmatory]
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47
[SID135644]
NCI Yeast Anticancer Drug Screen. Data for the sgs1 mgt1 strain [AID161, Type: other]
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48
[SID135644]
NCI Yeast Anticancer Drug Screen. Data for the cln2 rad14 strain [AID165, Type: other]
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49
[SID135644]
NCI Yeast Anticancer Drug Screen. Data for the bub3 strain [AID167, Type: other]
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50
[SID92764822]
Flow Cytometric HTS Screening for Inhibitors of Lytic Granule Exocytosis with compounds from Cherry Pick01 [AID651954, Type: screening]
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