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diquafosol (CID 148197) - Compound BioActivity Data
.
BioActivity Outcomes:
Active(17)
 
 
Inactive(2)
 
 
Unspecified(16)
 
 
BioAssay Types:
Literature(35)
 
 
 
 
BioActivity Types:
EC50(21)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 35    Data Row: 35   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103509241]
EC50 0.06Agonist activity at human P2Y purinoceptor 2 expressed in human 1321N1 cells assessed as increase in intracellular calcium concentration by spectrofluorimetry [AID647894, Type: Literature]P2Y purinoceptor 2 [gi:311033490]
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2
[SID103509241]
EC50 0.0945Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor Y114A mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level [AID350683, Type: Literature]
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3
[SID103509241]
EC50 0.1Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as calcium elevation by fura2/AM assay [AID460573, Type: Literature]P2Y purinoceptor 2 [gi:311033490]
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4
[SID103509241]
EC50 0.112Agonist activity at N-terminal HA epitope-tagged wild type 3 human P2Y2 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium level [AID350678, Type: Literature]P2Y purinoceptor 2 [gi:311033490]
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5
[SID103509241]
EC50 0.13Agonist activity at human recombinant P2Y4 receptor expressed in 1321N1 cells assessed as stimulation of phospholipase C [AID280298, Type: Literature]P2Y purinoceptor 4 [gi:1709524]
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6
[SID103509241]
EC50 0.13Agonist activity at human P2Y4 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assay [AID404834, Type: Literature]P2Y purinoceptor 4 [gi:1709524]
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7
[SID103509241]
EC50 0.145Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor Y118A mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level [AID350694, Type: Literature]
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8
[SID103509241]
EC50 0.179Agonist activity at N-terminal HA epitope-tagged wild type 4 human P2Y2 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium level [AID350679, Type: Literature]P2Y purinoceptor 2 [gi:311033490]
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9
[SID103509241]
EC50 0.21Agonist activity at human P2Y2 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assay [AID404832, Type: Literature]P2Y purinoceptor 2 [gi:311033490]
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10
[SID103509241]
EC50 0.21Agonist activity at human recombinant P2Y2 receptor expressed in 1321N1 cells assessed as stimulation of phospholipase C [AID280297, Type: Literature]P2Y purinoceptor 2 [gi:311033490]
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11
[SID103509241]
EC50 0.216Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor R194H mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level [AID350696, Type: Literature]
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12
[SID103509241]
EC50 0.231Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor Y198A mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level [AID350698, Type: Literature]
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13
[SID103509241]
EC50 0.394Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor R177A_R180A double mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level [AID350686, Type: Literature]
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14
[SID103509241]
EC50 0.419Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor R180A mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level [AID350690, Type: Literature]
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15
[SID103509241]
EC50 0.572Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor R177A mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level [AID350688, Type: Literature]
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16
[SID103509241]
EC50 1.16Agonist activity at human P2Y6 receptor expressed in human 1321N1 cells assessed as [3H]inositol phosphate accumulation by scintillation proximity assay [AID404830, Type: Literature]P2Y purinoceptor 6 [gi:2495018]
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17
[SID103509241]
EC50 20Agonist activity at human recombinant P2Y6 receptor expressed in 1321N1 cells assessed as intracellular calcium mobilization [AID280301, Type: Literature]P2Y purinoceptor 6 [gi:2495018]
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18
[SID103509241]
EC50 20Agonist activity at human cloned P2Y1 receptor expressed in human 1321N1 by FLIPR assay [AID304929, Type: Literature]P2Y purinoceptor 1 [gi:1352692]
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19
[SID103509241]
EC50 270Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor C278S mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level [AID350668, Type: Literature]
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20
[SID103509241]
EC50 300Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor S296A mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level [AID350672, Type: Literature]
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21
[SID103509241]
EC50 620Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor R272A mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level [AID350692, Type: Literature]
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22
[SID103509241]
Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor Y114A mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level relative to carbachol [AID350685, Type: Literature]
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23
[SID103509241]
Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor R180A mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level relative to carbachol [AID350691, Type: Literature]
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24
[SID103509241]
Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor R177A mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level relative to carbachol [AID350689, Type: Literature]
View
25
[SID103509241]
Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor R177A_R180A double mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level relative to carbachol [AID350687, Type: Literature]
View
26
[SID103509241]
Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor Y198A mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level relative to carbachol [AID350699, Type: Literature]
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27
[SID103509241]
Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor R194H mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level relative to carbachol [AID350697, Type: Literature]
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28
[SID103509241]
Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor Y118A mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level relative to carbachol [AID350918, Type: Literature]
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29
[SID103509241]
Ratio of EC50 for N-terminal HA epitope-tagged human P2Y2 receptor C278S mutant to EC50 for wild type 3 human P2Y2 receptor [AID350665, Type: Literature]
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30
[SID103509241]
Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor S296A mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level relative to carbachol [AID350671, Type: Literature]
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31
[SID103509241]
Stability of the compound assessed as human e-NPP1-mediated hydrolysis at pH 8.5 after 20 mins by HPLC analysis [AID644880, Type: Literature]
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32
[SID103509241]
Agonist activity at N-terminal HA epitope-tagged wild type 4 human P2Y2 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium level relative to carbachol [AID350684, Type: Literature]P2Y purinoceptor 2 [gi:311033490]
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33
[SID103509241]
Agonist activity at N-terminal HA epitope-tagged wild type 3 human P2Y2 receptor expressed in human 1321N1 cells assessed as increase in intracellular calcium level relative to carbachol [AID350673, Type: Literature]P2Y purinoceptor 2 [gi:311033490]
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34
[SID103509241]
Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor C278S mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level relative to carbachol [AID350708, Type: Literature]
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35
[SID103509241]
Agonist activity at N-terminal HA epitope-tagged human P2Y2 receptor R272A mutant expressed in human 1321N1 cells assessed as increase in intracellular calcium level up to 300 uM relative to carbachol [AID350712, Type: Literature]
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