AC1LSVR5 (CID 1472225) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(119)
 
 
Inactive(469)
 
 
Inconclusive(23)
 
 
Unspecified(1)
 
 
Top Targets:
7TM GPCR Srx(17)
 
 
 
alkPPc(12)
 
 
Bcl-2 like(10)
 
 
 
KCNQ channel(8)
 
 
 
Tryp SPc(6)
 
 
BioAssay Types:
Screening(432)
 
 
 
 
 
Confirmatory(167)
 
 
 
 
Literature(5)
 
 
BioActivity Types:
Potency(75)
 
 
 
 
IC50(56)
 
 
 
 
EC50(21)
 
 
 
 
AC50(3)
 
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 612    Data Row: 612   Total Pages: 13   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14729216]
CC50 1.12e-06Cytotoxicity counterscreen assay for transcriptional activators of heat shock protein 70 (Hsp70) [AID1259, Type: confirmatory]
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2
[SID14729216]
IC50 0.16Dose Response selectivity of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a 697B cell line using a luminescence assay [AID489033, Type: confirmatory]
View
3
[SID14729216]
IC50 0.2A High Throughput Confirmatory Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in the absence of Glycerol [AID449764, Type: confirmatory]
View
4
[SID14729216]
IC50 0.2High Throughput Screening Assay used to Identify Novel Compounds that Inhibit Mycobacterium Tuberculosis in 7H9 Media [AID449762, Type: confirmatory]
View
5
[SID14729216]
IC50 0.32Dose response confirmation of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay [AID489035, Type: confirmatory]
View
6
[SID14729216]
IC50 0.396Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4) [AID1692, Type: confirmatory]Sphingosine-1-phosphate receptor 4 [Homo sapiens] [gi:15929025]
View
7
[SID14729216]
IC50 0.396Fluorescence dose response cell-based high throughput screening assay for antagonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4) [AID1692, Type: confirmatory]Sphingosine-1-phosphate receptor 4 [Homo sapiens] [gi:15929025]
View
8
[SID14729216]
IC50 0.752Counterscreen for S1P2 Antagonists: Dose Response Cell-Based Screen to Identify Antagonists of CRE-BLA [AID856, Type: confirmatory]sphingosine 1-phosphate receptor 2 [Homo sapiens] [gi:134244587]
View
9
[SID14729216]
IC50 0.752Counterscreen for S1P2 Antagonists: Dose Response Cell-Based Screen to Identify Antagonists of CRE-BLA [AID856, Type: confirmatory]sphingosine 1-phosphate receptor 2 [Homo sapiens] [gi:134244587]
View
10
[SID14729216]
IC50 0.752Counterscreen for S1P2 Antagonists: Dose Response Cell-Based Screen to Identify Antagonists of CRE-BLA [AID856, Type: confirmatory]sphingosine 1-phosphate receptor 2 [Homo sapiens] [gi:134244587]
View
11
[SID14729216]
EC50 0.84E3 Ligase_Mutant_Dose Response [AID1442, Type: confirmatory]E3 ubiquitin-protein ligase Mdm2 isoform MDM2 [Homo sapiens] [gi:89993689]
View
12
[SID14729216]
EC50 0.84E3 Ligase_Mutant_Dose Response [AID1442, Type: confirmatory]E3 ubiquitin-protein ligase Mdm2 isoform MDM2 [Homo sapiens] [gi:89993689]
View
13
[SID14729216]
AC50 0.8547Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
View
14
[SID14729216]
IC50 0.87907Luminescence-based dose response cell-based high throughput screening assay for cytotoxic compounds using the IEC-6 intestinal epithelial cell line. [AID1972, Type: confirmatory]
View
15
[SID14729216]
EC50 0.96E3 Ligase dose-response_384 [AID1394, Type: confirmatory]E3 ubiquitin-protein ligase Mdm2 isoform MDM2 [Homo sapiens] [gi:89993689]
View
16
[SID14729216]
EC50 0.96E3 Ligase dose-response_384 [AID1394, Type: confirmatory]E3 ubiquitin-protein ligase Mdm2 isoform MDM2 [Homo sapiens] [gi:89993689]
View
17
[SID14729216]
IC50 0.967Dose Response Cell Based Assay for Antagonists of the S1P2 Receptor [AID851, Type: confirmatory]sphingosine 1-phosphate receptor 2 [Homo sapiens] [gi:134244587]
View
18
[SID14729216]
IC50 0.967Dose Response Cell Based Assay for Antagonists of the S1P2 Receptor [AID851, Type: confirmatory]sphingosine 1-phosphate receptor 2 [Homo sapiens] [gi:134244587]
View
19
[SID14729216]
IC50 0.967Dose Response Cell Based Assay for Antagonists of the S1P2 Receptor [AID851, Type: confirmatory]sphingosine 1-phosphate receptor 2 [Homo sapiens] [gi:134244587]
View
20
[SID14729216]
Potency 1qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1461, Type: confirmatory]NPSR1 gene product [Homo sapiens] [gi:46395496]
View
21
[SID14729216]
Potency 1qHTS Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1461, Type: confirmatory]NPSR1 gene product [Homo sapiens] [gi:46395496]
View
22
[SID14729216]
AC50 1.3ATP-based Luminescence in the Absence of Cytokines Measured in Cell-Based System Using Plate Reader - 2061-06_Inhibitor_Dose_CherryPick [AID463229, Type: confirmatory]
View
23
[SID14729216]
EC50 1.73E3 Ligase_WT_Dose Response [AID1444, Type: confirmatory]E3 ubiquitin-protein ligase Mdm2 isoform MDM2 [Homo sapiens] [gi:89993689]
View
24
[SID14729216]
EC50 1.73E3 Ligase_WT_Dose Response [AID1444, Type: confirmatory]E3 ubiquitin-protein ligase Mdm2 isoform MDM2 [Homo sapiens] [gi:89993689]
View
25
[SID14729216]
CC50 2.129A Cell Based Secondary Assay To Explore Cytotoxicity of Compounds that Inhibit Mycobacterium Tuberculosis [AID435019, Type: confirmatory]
View
26
[SID14729216]
Potency 2.2387Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1491, Type: confirmatory]NPSR1 gene product [Homo sapiens] [gi:46395496]
View
27
[SID14729216]
Potency 2.2387Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: cAMP Signal Transduction [AID1491, Type: confirmatory]NPSR1 gene product [Homo sapiens] [gi:46395496]
View
28
[SID14729216]
Potency 2.2387Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction [AID1489, Type: confirmatory]NPSR1 gene product [Homo sapiens] [gi:46395496]
View
29
[SID14729216]
Potency 2.2387Confirmation Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Calcium Signal Transduction [AID1489, Type: confirmatory]NPSR1 gene product [Homo sapiens] [gi:46395496]
View
30
[SID14729216]
IC50 2.255Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor [AID463214, Type: confirmatory]type-1 angiotensin II receptor [Homo sapiens] [gi:4501997]
View
31
[SID14729216]
IC50 2.255Dose Response screen for antagonists of Angiotensin II Receptor Type 1 to assess selectivity of uHTS small molecule antagonists hits of the APJ receptor [AID463214, Type: confirmatory]type-1 angiotensin II receptor [Homo sapiens] [gi:4501997]
View
32
[SID14729216]
IC50 3.76uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1778, Type: confirmatory]kappa-type opioid receptor [Homo sapiens] [gi:39725940]
View
33
[SID14729216]
IC50 3.76uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1778, Type: confirmatory]kappa-type opioid receptor [Homo sapiens] [gi:39725940]
View
34
[SID14729216]
IC50 3.76uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1778, Type: confirmatory]kappa-type opioid receptor [Homo sapiens] [gi:39725940]
View
35
[SID14729216]
IC50 3.76uHTS identification of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay [AID1778, Type: confirmatory]kappa-type opioid receptor [Homo sapiens] [gi:39725940]
View
36
[SID14729216]
IC50 4.24Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2784, Type: confirmatory]APLNR gene product [Homo sapiens] [gi:4885057]
View
37
[SID14729216]
IC50 4.24Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay [AID2784, Type: confirmatory]APLNR gene product [Homo sapiens] [gi:4885057]
View
38
[SID14729216]
IC50 4.455Fluorescence-based counterscreen assay for S1P4 antagonists: Cell-based dose response high throughput screening assay to identify antagonists of the Sphingosine 1-Phosphate Receptor 1 (S1P1) [AID1821, Type: confirmatory]S1PR1 gene product [Homo sapiens] [gi:13027636]
View
39
[SID14729216]
IC50 4.455Fluorescence-based counterscreen assay for S1P4 antagonists: Cell-based dose response high throughput screening assay to identify antagonists of the Sphingosine 1-Phosphate Receptor 1 (S1P1) [AID1821, Type: confirmatory]S1PR1 gene product [Homo sapiens] [gi:13027636]
View
40
[SID14729216]
IC50 4.706HTS Image-Based Screen for Selective Antagonists of the KOR Receptor [AID2136, Type: confirmatory]kappa-type opioid receptor [Homo sapiens] [gi:39725940]
View
41
[SID14729216]
IC50 4.706HTS Image-Based Screen for Selective Antagonists of the KOR Receptor [AID2136, Type: confirmatory]kappa-type opioid receptor [Homo sapiens] [gi:39725940]
View
42
[SID14729216]
IC50 4.706HTS Image-Based Screen for Selective Antagonists of the KOR Receptor [AID2136, Type: confirmatory]kappa-type opioid receptor [Homo sapiens] [gi:39725940]
View
43
[SID14729216]
IC50 4.706HTS Image-Based Screen for Selective Antagonists of the KOR Receptor [AID2136, Type: confirmatory]kappa-type opioid receptor [Homo sapiens] [gi:39725940]
View
44
[SID14729216]
Potency 5.0119qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
View
45
[SID14729216]
Potency 5.0119qHTS Assay for Inhibitors of Aldehyde Dehydrogenase 1 (ALDH1A1) [AID1030, Type: confirmatory]aldehyde dehydrogenase 1 family, member A1 [Homo sapiens] [gi:30582681]
View
46
[SID14729216]
IC50 5.5Dose response counterscreen of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a HEK-293T cell line using a luminescence assay [AID489041, Type: confirmatory]
View
47
[SID14729216]
EC50 5.743Luminescence Cell-Based Dose Confirmation HTS to Identify Inhibitors of Platelet Dense Granule Release [AID1889, Type: confirmatory]
View
48
[SID14729216]
Potency 10Counterscreen Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Muscarinic Receptor Calcium Signal Transduction. [AID1492, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
View
49
[SID14729216]
Potency 10Counterscreen Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Muscarinic Receptor Calcium Signal Transduction. [AID1492, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
View
50
[SID14729216]
Potency 10Counterscreen Concentration-Response Assay for Antagonists of the Neuropeptide S Receptor: Muscarinic Receptor Calcium Signal Transduction. [AID1492, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
View