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10K-356S (CID 1472216) - Compound BioActivity Data
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BioActivity Outcomes:
Active(201)
 
 
Inactive(642)
 
 
Inconclusive(28)
 
 
Unspecified(9)
 
 
Top Targets:
7TM GPCR Srx(27)
 
 
 
 
7TM GPCR Srsx(21)
 
 
 
 
Bcl-2 like(17)
 
 
alkPPc(12)
 
 
RGS RGS4(9)
 
 
 
 
BioAssay Types:
Screening(556)
 
 
 
 
 
Confirmatory(297)
 
 
 
 
 
Literature(11)
 
 
BioActivity Types:
Potency(160)
 
 
 
 
 
IC50(78)
 
 
 
 
 
EC50(37)
 
 
 
AC50(11)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 796    Data Row: 880   Total Pages: 44   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID14729238]
CC50 1.75e-06Cytotoxicity counterscreen assay for transcriptional activators of heat shock protein 70 (Hsp70) [AID1259, Type: confirmatory]
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2
[SID14729238]
Potency 0.0184qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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3
[SID14729238]
Potency 0.0206qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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4
[SID14729238]
EC50 0.185High Throughput Screen to Identify Compounds that Suppress the Growth of Human Colon Tumor Cells Lacking Oncogenic Beta Catenin Expression - Dose Response [AID1045, Type: confirmatory]
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5
[SID14729238]
EC50 0.197High Throughput Screen to Identify Compounds that Suppress the Growth of Cells with a Deletion of the PTEN Tumor Suppressor - Dose Response [AID1047, Type: confirmatory]
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6
[SID14729238]
IC50_Mean 0.26Dose response confirmation of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a Jurkat cell line using a luminescence assay [AID489035, Type: confirmatory]
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7
[SID14729238]
AC50_uM 0.26Schnurri-3 Inhibitors: specific inducers of adult bone formation Measured in Cell-Based System Using Plate Reader - 2134-01_Inhibitor_Dose_CherryPick_Activity [AID624132, Type: confirmatory]
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8
[SID14729238]
AC50_uM 0.26Shn3: Dual-Go Shn3RL cells Measured in Cell-Based System Using Plate Reader - 2134-02_Inhibitor_Dose_CherryPick_Activity [AID624133, Type: confirmatory]
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9
[SID14729238]
Potency 0.3162qHTS Assay for the Inhibitors of Schistosoma Mansoni Peroxiredoxins [AID485364, Type: confirmatory]thioredoxin glutathione reductase [Schistosoma mansoni] [gi:15149312]
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10
[SID14729238]
IC50 0.45344Counterscreen for inhibitors of TLR9-MyD88 binding: Luminescence-based cell-based high throughput dose response assay to identify cytotoxic compounds using TLR9-MyD88 CHO cells [AID588339, Type: confirmatory]
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11
[SID14729238]
IC50_Mean 0.6Dose Response selectivity of uHTS chemical inhibitors of T-cell specific antigen receptor-induced NF-kB activation in a 697B cell line using a luminescence assay [AID489033, Type: confirmatory]
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12
[SID14729238]
Potency 0.7943qHTS Assay for Inhibitors of Hepatitis C Virus (HCV) [AID651820, Type: confirmatory]
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13
[SID14729238]
IC50 0.92Luminescence-based cell-based high throughput dose response assay for agonists of nuclear receptor subfamily 2, group E, member 3 (NR2E3) [AID624394, Type: confirmatory]photoreceptor-specific nuclear receptor [Homo sapiens] [gi:216409728]
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14
[SID14729238]
IC50 0.942Dose Response Cell Based Assay for Antagonists of the S1P2 Receptor [AID851, Type: confirmatory]sphingosine 1-phosphate receptor 2 [Homo sapiens] [gi:134244587]
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15
[SID14729238]
EC50 0.998Luminescence Cell-Based Dose Response HTS to Identify Inhibitors of 5'UTR Stem-Loop Driven Prion Protein mRNA Translation in H4 Neuroglioblastoma Cells [AID1994, Type: confirmatory]
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16
[SID14729238]
Potency 1qHTS for inhibitors of ROR gamma transcriptional activity [AID2551, Type: confirmatory]nuclear receptor ROR-gamma isoform 1 [Mus musculus] [gi:188536040]
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17
[SID99494293]
IC50 1Biochemical assay for compounds that inhibit RGS4 stimulation of Galpha1 nucleotide hydrolysis under receptor-independent steady-state conditions [AID588552, Type: confirmatory]regulator of G-protein signaling 4 [Rattus norvegicus] [gi:8394183]
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18
[SID99494293]
IC50 1Biochemical assay for compounds that inhibit RGS4 stimulation of Galpha1 nucleotide hydrolysis under receptor-independent steady-state conditions [AID588552, Type: confirmatory] [geneid:29480]
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19
[SID14729238]
AC50_uM 1.104Luminescence Cell-Based Dose Retest to Confirm Inhibitors of Beta Cell Apoptosis [AID449756, Type: confirmatory]
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20
[SID14729238]
EC50 for replicate 3 1.11601High throughput discovery of novel modulators of ROMK K+ channel activity: Dose-Response Assay [AID2753, Type: confirmatory]Potassium inwardly-rectifying channel, subfamily J, member 1 [Homo sapiens] [gi:223460826]
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