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Ethidium (CID 14710) - Compound BioActivity Data
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BioActivity Outcomes:
Active(567)
 
 
Inactive(500)
 
 
Inconclusive(209)
 
 
Unspecified(372)
 
 
Top Targets:
NR LBD AR(23)
 
 
 
 
NR LBD PPAR(23)
 
 
 
 
NR LBD ER(23)
 
 
 
 
NR LBD TR(15)
 
 
 
 
7TM GPCR Srsx(15)
 
 
 
BioAssay Types:
Confirmatory(598)
 
 
 
 
 
Literature(515)
 
 
 
 
 
Screening(237)
 
 
 
 
Summary(63)
 
 
 
 
BioActivity Types:
Potency(524)
 
 
 
 
 
IC50(31)
 
 
 
 
 
AC50(9)
 
 
 
Kd(3)
 
 
EC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 1088    Data Row: 1648   Total Pages: 33   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID26748838]
Potency 0.003Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504834, Type: confirmatory]
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2
[SID17389015]
Potency 0.019Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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3
[SID26748838]
Potency 0.0282Confirmation screen for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation [AID504848, Type: confirmatory]
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4
[SID26748838]
Potency 0.0478Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504832, Type: confirmatory]
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5
[SID144209709]
Potency-Replicate_1 0.0859qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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6
[SID144209709]
Potency-Replicate_1 0.0964qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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7
[SID103207558]
IC50 0.1Concentration required to inhibit 50% of human carcinoma A2780 cell lines [AID248000, Type: Literature]
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8
[SID92764758]
Potency 0.1458qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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9
[SID92764758]
Potency 0.1636qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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10
[SID144209709]
Potency-Replicate_1 0.1714qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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11
[SID144204674]
Potency-Replicate_1 0.2113qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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12
[SID144204674]
Potency 0.2371qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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13
[SID144204674]
Potency 0.2661qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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14
[SID144204674]
Potency-Replicate_1 0.2985qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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15
[SID144204963]
Potency 0.3264qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in absence of CPT [AID686978, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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16
[SID144204674]
Potency-Replicate_1 0.3758qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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17
[SID103207558]
IC50 0.4Concentration required to inhibit 50% of human carcinoma CH1 cell lines [AID247965, Type: Literature]
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18
[SID17389015]
Potency 0.4992qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation [AID504374, Type: confirmatory]core-binding factor subunit beta isoform 2 [Homo sapiens] [gi:13124873]
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19
[SID17389015]
Potency 0.4992qHTS Assay for Compounds Blocking the Interaction Between CBF-beta and RUNX1 for the Treatment of Acute Myeloid Leukemia: Hit Validation [AID504374, Type: confirmatory]runt-related transcription factor 1 isoform AML1b [Homo sapiens] [gi:49574546]
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20
[SID144204963]
Potency 0.5174qHTS for Inhibitors of human tyrosyl-DNA phosphodiesterase 1 (TDP1): qHTS in cells in presence of CPT [AID686979, Type: confirmatory]TDP1 protein [Homo sapiens] [gi:79154014]
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21
[SID144204963]
Potency-Replicate_1 0.5308qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - wild type cell line [AID743012, Type: confirmatory]
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22
[SID103207558]
EC50 0.6Antiviral activity against Hepatitis C virus H2B2 [AID472813, Type: Literature]
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23
[SID144209709]
Potency-Replicate_1 0.6137qHTS assay to identify small molecule agonists of the farnesoid-X-receptor (FXR) signaling pathway - cell viability counter screen [AID743218, Type: confirmatory]
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24
[SID103207558]
CC50 0.7Cytotoxicity against human HBI10A cells [AID472812, Type: Literature]
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25
[SID144204963]
Potency-Replicate_1 0.7498qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rad54/Ku70 mutant cell line [AID743015, Type: confirmatory]
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26
[SID103207558]
IC50 0.81Inhibition of HCV genotype 1b NS5B polymerase deltaC21 mutant [AID472809, Type: Literature]
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27
[SID144204963]
Potency-Replicate_1 0.8413qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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28
[SID144209709]
Potency-Replicate_1 0.9727qHTS assay to identify small molecule antagonists of the vitamin D receptor (VDR) signaling pathway - cell viability counter screen [AID743225, Type: confirmatory]
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29
[SID26748838]
Potency 1Confirmation screen for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation [AID504850, Type: confirmatory]
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30
[SID92764758]
IC50 1.558Fluorescence-based biochemical high throughput screening dose response assay to identify inhibitors of Crimean-Congo Hemorrhagic Fever (CCHF) viral ovarian tumor domain protease (vOTU): Pep-AMC substrate [AID720578, Type: confirmatory]putative polyprotein [Crimean-Congo hemorrhagic fever virus] [gi:76364066]
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31
[SID170466062]
Ratio Potency (uM) 1.9948qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway: Summary [AID743219, Type: summary]nuclear factor erythroid 2-related factor 2 isoform 1 [Homo sapiens] [gi:20149576]
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32
[SID103207558]
IC50 2Inhibition of HIV-1 reverse transcriptase using Poly(rA).p(dT) (12 to 18) as substrate after 30 mins by single point PCR assay [AID695925, Type: Literature]
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33
[SID144209709]
Potency-Replicate_1 2.158qHTS assay for small molecule agonists of the p53 signaling pathway [AID651631, Type: confirmatory]Cellular tumor antigen p53 [gi:269849759]
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34
[SID144209709]
Ratio Potency (uM) 2.17761qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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35
[SID144204963]
Potency-Replicate_1 2.2095qHTS assay for small molecule disruptors of the mitochondrial membrane potential [AID720635, Type: confirmatory]
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36
[SID144209709]
Ratio Potency (uM) 2.24239qHTS assay for small molecule agonists of the p53 signaling pathway: Summary [AID720552, Type: summary]Cellular tumor antigen p53 [gi:269849759]
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37
[SID103207558]
IC50 2.39Inhibition of telomerase-mediated supercoiling activity in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA assay [AID725721, Type: Literature]Telomerase reverse transcriptase [gi:6226780]
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38
[SID92764758]
AC50_uM 2.42MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set3 [AID493073, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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39
[SID92764758]
AC50_uM 2.42MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set4 [AID493102, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
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40
[SID92764758]
AC50_uM 2.42MITF Measured in Cell-Based System Using Plate Reader - 2084-01_Inhibitor_DoseNoFile_CherryPick_Activity_Set2 [AID493177, Type: confirmatory]Microphthalmia-associated transcription factor [Homo sapiens] [gi:40807040]
View
41
[SID103207558]
IC50 2.47Inhibition of telomerase supercoiling activity in human MGC803 cells after 24 hrs by TRAP-PCR-ELISA assay [AID653484, Type: Literature]Telomerase reverse transcriptase [gi:6226780]
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42
[SID103207558]
IC50 2.5Inhibition of telomerase in human SGC7901 cells by TRAP assay [AID516696, Type: Literature]Telomerase reverse transcriptase [gi:6226780]
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43
[SID103207558]
IC50 2.5Inhibition of telomerase in human SGC7901 cells by TRAP assay [AID537601, Type: Literature]Telomerase reverse transcriptase [gi:6226780]
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44
[SID26748838]
Potency 2.5119qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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45
[SID103207558]
IC50 2.6Inhibition of telomerase in human SGC7901 cells by TRAP assay [AID735444, Type: Literature]Telomerase reverse transcriptase [gi:6226780]
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46
[SID103207558]
IC50 2.6Inhibition of telomerase activity expressed in human SGC7901 cells by SYBER green dye based TRAP [AID594636, Type: Literature]
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47
[SID144209709]
Potency-Replicate_1 2.7414qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway [AID743036, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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48
[SID144204674]
Ratio Potency (uM) 2.78822qHTS assay to identify small molecule agonists of the androgen receptor (AR) signaling pathway: Summary [AID743053, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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49
[SID92764758]
Potency 2.9935qHTS for Inhibitors of WRN Helicase [AID651768, Type: confirmatory]WRN [Homo sapiens] [gi:3719421]
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50
[SID103207558]
IC50 3.13Tested for the binding of [3H]dizocilpine to DEPC (diethylpyrocarbonate) membranes of rat [AID144987, Type: other]
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