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BioActivity Data for Compound Citalopram (CID 146570)

BioActivity Outcomes:
Active(13)
 
 
Inactive(158)
 
 
Inconclusive(25)
 
 
Unspecified(13)
 
 
Top Targets:
p450(18)
 
 
 
 
SLC6sbd SERT(9)
 
 
 
HSD10-like SD..(8)
 
 
GH27(5)
 
 
ampC(4)
 
 
BioAssay Types:
Confirmatory(156)
 
 
 
 
Literature(20)
 
 
 
 
Screening(9)
 
 
BioAssay Categories:
In vivo(1)
 
 
Biochemical(16)
 
 
 
 
Toxicity(4)
 
 
ADME(1)
 
 
Cell-based(15)
 
 
 
 
BioActivity Types:
Potency(114)
 
 
 
 
Ki(6)
 
 
IC50(2)
 
 
 
Kd(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 147    Data Row: 209   Total Pages: 11   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103558387]
Ki 0.00089Displacement of [3H]citalopram from SERT in rat brain stem by scintillation counting [AID499947, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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2
[SID103558387]
Ki 0.001Displacement of [3H]citalopram form human SRET by liquid scintillation counting [AID479241, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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3
[SID103558387]
Ki 0.001Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assay [AID448409, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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4
[SID103558387]
Kd 0.0026Binding affinity to human SERT expressed in African green monkey COS7 cells after 2 hrs by scintillation counting analysis [AID1156233, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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5
[SID103558387]
Ki 0.0074Inhibition of 5-hydroxy[3H]tryptamine uptake at human SERT expressed in African green monkey COS7 cells incubated for 10 mins prior to radioligand addition measured after 5 mins by scintillation counting analysis [AID1156227, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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6
[SID11114081]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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7
[SID11114081]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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8
[SID103558387]
IC50 4.6Allosteric modulation at wild-type human SERT site S2 expressed in african green monkey COS7 cells assessed as inhibition of [3H]citalopram dissociation at 30 uM by scintillation counting analysis [AID1058859, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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9
[SID103558387]
Ki 8.15Displacement of [3H]WIN-35428 from DAT in rat caudate-putamen by scintillation counting [AID499949, Type: Literature]Sodium-dependent dopamine transporter [gi:128613]
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10
[SID11110983]
Potency 10qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Measurement of IP-One Response [AID944, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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11
[SID103558387]
Ki 10.5Displacement of [3H]nisoxetine from NET in rat frontal cortex by scintillation counting [AID499948, Type: Literature]Norepinephrine transporter [gi:81890335]
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12
[SID11114081]
Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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13
[SID11114081]
Cytochrome panel assay with activity outcomes [AID1851_1, Type: other]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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14
[SID103558387]
IC50 1560Displacement of [3H]leucine from Leucine transporter [AID499952, Type: Literature]
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15
[SID103558387]
Selectivity ratio of Ki for DAT in rat caudate-putamen to Ki for SERT in rat brain stem [AID499951, Type: Literature]
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16
[SID103558387]
Selectivity ratio of Ki for NET in rat brain frontal cortex to Ki for SERT in rat brain stem [AID499950, Type: Literature]
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17
[SID103558387]
Octan-1-ol/water (pH7.4) distribution coefficent measured by a shake flask method described in J. Biomol. Screen. 2011, 16, 348-355. Experimental range -1.5 to 4.5 [AID1159387, Type: other]
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18
[SID103558387]
Antistress activity against chronic mild stress Sprague-Dawley rat model assessed as increase sucrose consumption at 5 mg/kg, ip bid measured after 4 weeks [AID620922, Type: Literature]
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19
[SID103558387]
Antidepression activity in sc dosed Harlan rat assessed as increase in extracellular 5HT level in ventral hippocampus region measured up to 180 mins by microdialysis method relative to vehicle-treated control [AID712468, Type: Literature]
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20
[SID103558387]
Allosteric modulation at wild-type human SERT site S2 expressed in african green monkey COS7 cells assessed as inhibition of [3H]citalopram dissociation by measuring half life at 30 uM at 24 degC by scintillation counting analysis [AID1058860, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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