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Citalopram (CID 146570) - Compound BioActivity Data
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BioActivity Outcomes:
Active(10)
 
 
Inactive(155)
 
 
Inconclusive(25)
 
 
Unspecified(9)
 
 
Top Targets:
p450(18)
 
 
 
 
HSD10-like SD..(8)
 
 
PLN02808(5)
 
 
BRCT(4)
 
 
Tubulin-bindi..(4)
 
 
 
BioAssay Types:
Confirmatory(155)
 
 
 
 
Literature(12)
 
 
 
Screening(9)
 
 
BioActivity Types:
Potency(113)
 
 
 
 
Ki(5)
 
 
IC50(1)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 137    Data Row: 199   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103558387]
Ki 0.00089Displacement of [3H]citalopram from SERT in rat brain stem by scintillation counting [AID499947, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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2
[SID103558387]
Ki 0.001Displacement of [3H]citalopram form human SRET by liquid scintillation counting [AID479241, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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3
[SID103558387]
Ki 0.001Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assay [AID448409, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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4
[SID11114081]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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5
[SID11114081]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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6
[SID103558387]
Ki 8.15Displacement of [3H]WIN-35428 from DAT in rat caudate-putamen by scintillation counting [AID499949, Type: Literature]Sodium-dependent dopamine transporter [gi:128613]
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7
[SID11110983]
Potency 10qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Measurement of IP-One Response [AID944, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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8
[SID103558387]
Ki 10.5Displacement of [3H]nisoxetine from NET in rat frontal cortex by scintillation counting [AID499948, Type: Literature]Norepinephrine transporter [gi:81890335]
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9
[SID11114081]
Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450 2C9 precursor [Homo sapiens] [gi:13699818]
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10
[SID11114081]
Cytochrome panel assay with activity outcomes [AID1851_1, Type: other]cytochrome P450 2C19 precursor [Homo sapiens] [gi:4503219]
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11
[SID103558387]
IC50 1560Displacement of [3H]leucine from Leucine transporter [AID499952, Type: Literature]
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12
[SID103558387]
Solubility of the compound in 0.1 M phosphate buffer at 600 uM at pH 7.4 after 24 hrs by LC/MS/MS analysis [AID539464, Type: Literature]
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13
[SID103558387]
Antistress activity against chronic mild stress Sprague-Dawley rat model assessed as increase sucrose consumption at 5 mg/kg, ip bid measured after 4 weeks [AID620922, Type: Literature]
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14
[SID103558387]
Antidepression activity in sc dosed Harlan rat assessed as increase in extracellular 5HT level in ventral hippocampus region measured up to 180 mins by microdialysis method relative to vehicle-treated control [AID712468, Type: Literature]
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15
[SID11110983]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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16
[SID11114081]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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17
[SID103558387]
Oral bioavailability in human [AID311524, Type: Literature]
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18
[SID103558387]
Selectivity ratio of Ki for NET in rat brain frontal cortex to Ki for SERT in rat brain stem [AID499950, Type: Literature]
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19
[SID103558387]
Selectivity ratio of Ki for DAT in rat caudate-putamen to Ki for SERT in rat brain stem [AID499951, Type: Literature]
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20
[SID11110983]
Potency 1qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450 3A4 isoform 1 [Homo sapiens] [gi:13435386]
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21
[SID11114081]
Potency 7.9433qHTS Assay for Compounds that Induce Erasure of Genomic Imprints [AID1948, Type: confirmatory]
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22
[SID11110983]
Potency 15.8489qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) [AID881, Type: confirmatory]Arachidonate 15-lipoxygenase B [gi:317373425]
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23
[SID11114081]
Potency 15.8489qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) [AID881, Type: confirmatory]Arachidonate 15-lipoxygenase B [gi:317373425]
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24
[SID11110983]
qHTS Assay for Tau Filament Binding [AID596, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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25
[SID11110983]
Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) [AID584, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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26
[SID11110983]
Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID585, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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27
[SID11114081]
Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) [AID584, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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28
[SID11114081]
Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID585, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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29
[SID11114081]
Potency qHTS Assay for Inhibitors and Activators of Human alpha-Glucosidase From Spleen Homogenate [AID2112, Type: confirmatory]lysosomal alpha-glucosidase preproprotein [Homo sapiens] [gi:119393891]
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30
[SID11114081]
Potency qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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31
[SID11114081]
Potency qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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32
[SID11110983]
Potency qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Nonpermissive Temperature [AID902, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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33
[SID11110983]
Potency qHTS Screen for Compounds that Selectively Target Cancer Cells with p53 Mutations: Cytotoxicity of p53ts Cells at the Permissive Temperature [AID924, Type: confirmatory]cellular tumor antigen p53 isoform a [Homo sapiens] [gi:120407068]
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34
[SID11110983]
Potency qHTS Assay for Identification of Small Molecule Agonists for Thrombopoietin (TPO) Signaling Pathway [AID917, Type: confirmatory]Thrombopoietin [Homo sapiens] [gi:120660324]
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35
[SID85789669]
Luminescence Cell-Based Primary HTS to Measure Viability of BJeLR cells [AID2275, Type: screening]
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36
[SID85789669]
Luminescence Cell-Based Primary HTS to Identify Inhibitors of the Sonic Hedgehog Signaling Pathway [AID2313, Type: screening]
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37
[SID85789669]
Luminescence Homogenous Primary HTS to Identify Inhibitors of STK33 Activity [AID2322, Type: screening]
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38
[SID85789669]
Fluorescence Cell-Based Primary HTS to Measure Inhibition of Y box Binding Protein 1 Expression [AID434959, Type: screening]
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39
[SID85789669]
Fluorescence Cell-Based Primary HTS to Identify Reactive Oxygen Species Inducers in Cancer Cells Measured in Cell-Based System Using Plate Reader and Imaging Combination - 2044-01_Activator_SinglePoint_HTS_Activity [AID624156, Type: screening]
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40
[SID92308964]
A screen for compounds that inhibit liver stage malaria [AID624349, Type: other]
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41
[SID11114081]
Potency Quantitative High-Throughput Screen for Regulators of Epigenetic Control [AID1865, Type: confirmatory]
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42
[SID11110983]
qHTS Assay for Spectroscopic Profiling in Rhodamine Spectral Region [AID594, Type: confirmatory]
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43
[SID11110983]
qHTS Assay for Disrupters of an Hsp90 Co-Chaperone Interaction [AID595, Type: confirmatory]
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44
[SID11110983]
Ubiquitin-GFP Assay [AID526, Type: confirmatory]
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45
[SID11110983]
qHTS Assay for Epigenetic Modulators [AID597, Type: confirmatory]
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46
[SID11110983]
qHTS Assay for Inhibitors of DNA Polymerase III Holoenzyme System [AID603, Type: confirmatory]
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47
[SID11110983]
Cell signaling CRE-BLA (Fsk stim) [AID662, Type: confirmatory]
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48
[SID11110983]
Potency qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1: Spectroscopic Profiling in AFC Spectral Region [AID923, Type: confirmatory]
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49
[SID11110983]
AP1 Signaling Pathway [AID357, Type: confirmatory]
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50
[SID11110983]
Stat Signaling Pathway [AID446, Type: confirmatory]
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