Citalopram (CID 146570) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(10)
 
 
Inactive(144)
 
 
Inconclusive(24)
 
 
Unspecified(8)
 
 
Top Targets:
p450(20)
 
 
 
 
 
PLN02808(5)
 
 
Pyruvate Kina..(4)
 
 
P53(4)
 
 
NR LBD GR(4)
 
 
BioAssay Types:
Confirmatory(145)
 
 
 
 
Literature(11)
 
 
 
Screening(9)
 
 
BioActivity Types:
Potency(104)
 
 
 
 
Ki(5)
 
 
IC50(1)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 132    Data Row: 186   Total Pages: 4   Display: Page     
Sort: [Click the result table header to sort]
#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103558387]
Ki 0.00089Displacement of [3H]citalopram from SERT in rat brain stem by scintillation counting [AID499947, Type: Literature]Sodium-dependent serotonin transporter [gi:400629]
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2
[SID103558387]
Ki 0.001Displacement of [3H]citalopram form human SRET by liquid scintillation counting [AID479241, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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3
[SID103558387]
Ki 0.001Displacement of [3H]citalopram form human SRET by liquid scintillation counting [AID479241, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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4
[SID103558387]
Ki 0.001Displacement of [3H]citalopram form human SRET by liquid scintillation counting [AID479241, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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5
[SID103558387]
Ki 0.001Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assay [AID448409, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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6
[SID103558387]
Ki 0.001Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assay [AID448409, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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7
[SID103558387]
Ki 0.001Displacement of [3H]citalopram from human serotonin transporter expressed in HEK293 cells by scintillation proximity assay [AID448409, Type: Literature]Sodium-dependent serotonin transporter [gi:400630]
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8
[SID11114081]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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9
[SID11114081]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C19 [AID899, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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10
[SID11114081]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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11
[SID11114081]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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12
[SID11114081]
Potency 3.1623qHTS Assay for Inhibitors and Substrates of Cytochrome P450 2C9 [AID883, Type: confirmatory]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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13
[SID103558387]
Ki 8.15Displacement of [3H]WIN-35428 from DAT in rat caudate-putamen by scintillation counting [AID499949, Type: Literature]Sodium-dependent dopamine transporter [gi:128613]
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14
[SID11110983]
Potency 10qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Measurement of IP-One Response [AID944, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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15
[SID11110983]
Potency 10qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Measurement of IP-One Response [AID944, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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16
[SID11110983]
Potency 10qHTS Assay for Antagonists of Acetylcholine Muscarinic M1 Receptor: Measurement of IP-One Response [AID944, Type: confirmatory]muscarinic acetylcholine receptor M1 [Rattus norvegicus] [gi:18249941]
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17
[SID103558387]
Ki 10.5Displacement of [3H]nisoxetine from NET in rat frontal cortex by scintillation counting [AID499948, Type: Literature]Norepinephrine transporter [gi:81890335]
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18
[SID11114081]
 Cytochrome panel assay with activity outcomes [AID1851_1, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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19
[SID11114081]
 Cytochrome panel assay with activity outcomes [AID1851_1, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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20
[SID11114081]
 Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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21
[SID11114081]
 Cytochrome panel assay with activity outcomes [AID1851_5, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 9 [Homo sapiens] [gi:13699818]
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22
[SID103558387]
IC50 1560Displacement of [3H]leucine from Leucine transporter [AID499952, Type: Literature]
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23
[SID103558387]
 Solubility of the compound in 0.1 M phosphate buffer at 600 uM at pH 7.4 after 24 hrs by LC/MS/MS analysis [AID539464, Type: Literature]
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24
[SID103558387]
 Antistress activity against chronic mild stress Sprague-Dawley rat model assessed as increase sucrose consumption at 5 mg/kg, ip bid measured after 4 weeks [AID620922, Type: Literature]
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25
[SID103558387]
 Oral bioavailability in human [AID311524, Type: Literature]
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26
[SID103558387]
 Selectivity ratio of Ki for NET in rat brain frontal cortex to Ki for SERT in rat brain stem [AID499950, Type: Literature]
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27
[SID103558387]
 Selectivity ratio of Ki for DAT in rat caudate-putamen to Ki for SERT in rat brain stem [AID499951, Type: Literature]
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28
[SID11114081]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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29
[SID11114081]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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30
[SID11110983]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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31
[SID11110983]
 Cytochrome panel assay with activity outcomes [AID1851, Type: other]cytochrome P450, family 2, subfamily C, polypeptide 19 [Homo sapiens] [gi:4503219]
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32
[SID11110983]
Potency 1qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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33
[SID11110983]
Potency 1qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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34
[SID11110983]
Potency 1qHTS Assay for Activators of Cytochrome P450 3A4 [AID885, Type: confirmatory]cytochrome P450, family 3, subfamily A, polypeptide 4 [Homo sapiens] [gi:13435386]
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35
[SID11114081]
Potency 7.9433qHTS Assay for Compounds that Induce Erasure of Genomic Imprints [AID1948, Type: confirmatory]
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36
[SID11110983]
Potency 15.8489qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) [AID881, Type: confirmatory]Arachidonate 15-lipoxygenase B [gi:317373425]
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37
[SID11114081]
Potency 15.8489qHTS Assay for Inhibitors of 15-hLO-2 (15-human lipoxygenase 2) [AID881, Type: confirmatory]Arachidonate 15-lipoxygenase B [gi:317373425]
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38
[SID11114081]
Potency qHTS Assay for Inhibitors of Bloom's syndrome helicase (BLM) [AID2528, Type: confirmatory]Bloom syndrome protein [Homo sapiens] [gi:4557365]
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39
[SID11114081]
Potency qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1 [AID900, Type: confirmatory]caspase-1 isoform alpha precursor [Homo sapiens] [gi:15431328]
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40
[SID11114081]
Potency qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1 [AID900, Type: confirmatory]caspase-1 isoform alpha precursor [Homo sapiens] [gi:15431328]
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41
[SID11110983]
Potency qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1 [AID900, Type: confirmatory]caspase-1 isoform alpha precursor [Homo sapiens] [gi:15431328]
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42
[SID11110983]
Potency qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-1 [AID900, Type: confirmatory]caspase-1 isoform alpha precursor [Homo sapiens] [gi:15431328]
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43
[SID11114081]
Potency qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7 [AID889, Type: confirmatory]Caspase-7 [gi:1730092]
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44
[SID11114081]
Potency qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7 [AID889, Type: confirmatory]Caspase-7 [gi:1730092]
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45
[SID11110983]
Potency qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7 [AID889, Type: confirmatory]Caspase-7 [gi:1730092]
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46
[SID11110983]
Potency qHTS Assay for Allosteric/Competitive Inhibitors of Caspase-7 [AID889, Type: confirmatory]Caspase-7 [gi:1730092]
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47
[SID11110983]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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48
[SID11110983]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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49
[SID11110983]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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50
[SID11114081]
 p450-cyp1a2 [AID410, Type: confirmatory]cytochrome P450, family 1, subfamily A, polypeptide 2 [Homo sapiens] [gi:73915100]
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