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Proline (CID 145742) - Compound BioActivity Data
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BioActivity Outcomes:
Active(1)
 
 
Inactive(166)
 
 
Inconclusive(3)
 
 
Unspecified(11)
 
 
Top Targets:
p450(9)
 
 
HSD10-like SD..(4)
 
 
Firefly Luc l..(3)
 
 
Bromo ALL-1(3)
 
 
PTB RGS12(2)
 
 
BioAssay Types:
Confirmatory(95)
 
 
 
Literature(73)
 
 
 
 
BioActivity Types:
Potency(68)
 
 
 
Ki(3)
 
 
IC50(2)
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 108    Data Row: 181   Total Pages: 10   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103241620]
Induction of nitrogen-starved wild type sigma1278b yeast Gap1-mediated trehalose activation at 10 mM [AID500825, Type: Literature]
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2
[SID103241620]
Ki 86Inhibition of ACE (unknown origin) assessed as 3-Hydroxybutyril-glycil-glycil-glycine conversion to 3-hydroxybutyric acid after 60 mins by WST assay [AID1053270, Type: Literature]Angiotensin-converting enzyme [gi:113045]
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3
[SID103241620]
IC50 414Inhibitory concentration required to inhibit [3H]strychnine binding to N-methyl-D-aspartate glutamate receptor 1 [AID143614, Type: Literature]
View
4
[SID103241620]
Ki 1600Inhibition of human PAT1-mediated L-[3H]proline uptake in human Caco2 cells after 10 mins by liquid scintillation counting [AID630741, Type: Literature]Proton-coupled amino acid transporter 1 [gi:51316800]
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5
[SID4253464]
Cytochrome panel assay with activity outcomes [AID1851, Type: other]
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6
[SID103241620]
Partition coefficient (logP) [AID26797, Type: Literature]
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7
[SID103241620]
Affinity of compound towards the carnitine/acylcarnitine translocase was determined by monitoring the efflux of [14C]L-carnitine from isolated rat heart mitochondria [AID49192, Type: Literature]
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8
[SID103241620]
Inhibition of ACE (unknown origin) assessed as 3-Hydroxybutyril-glycil-glycil-glycine conversion to 3-hydroxybutyric acid at 500 uM after 60 mins by WST assay relative to control [AID1053271, Type: Literature]Angiotensin-converting enzyme [gi:113045]
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9
[SID4253464]
qHTS profiling for inhibitors of Plasmodium falciparum proliferation [AID504749, Type: Literature]
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10
[SID103241620]
Virtual screen for compounds with anticonvulsant activity [AID227699, Type: Literature]
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11
[SID103241620]
Bitter threshold value [AID233318, Type: Literature]
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12
[SID103241620]
Ki TP_TRANSPORTER: inhibition of L-tryptophan uptake in Xenopus laevis oocytes [AID681113, Type: Literature]Monocarboxylate transporter 10 [gi:81871541]
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13
[SID4253464]
qHTS Assay for Inhibitors of PDE-IV [AID607, Type: confirmatory]cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform 1 [Homo sapiens] [gi:82799486]
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14
[SID4253464]
qHTS Assay for Inhibitors of YjeE [AID605, Type: confirmatory]tRNA threonylcarbamoyladenosine biosynthesis protein TsaE [gi:84028058]
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15
[SID4253464]
qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Cytoprotection (ATP) [AID1471, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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16
[SID4253464]
Potency qHTS Multiplex Assay to Identify Dual Action Probes in a Cell Model of Huntington: Aggregate Formation (GFP) [AID1688, Type: confirmatory]huntingtin [Homo sapiens] [gi:90903231]
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17
[SID4253464]
qHTS Assay for Tau Filament Binding [AID596, Type: confirmatory]Microtubule-associated protein tau [Homo sapiens] [gi:92096784]
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18
[SID4253464]
Potency Inhibitors of USP1/UAF1: Pilot qHTS [AID504865, Type: confirmatory]USP1 protein, partial [Homo sapiens] [gi:118600387]
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19
[SID4253464]
Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay with detergent) [AID584, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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20
[SID4253464]
Promiscuous and Specific Inhibitors of AmpC Beta-Lactamase (assay without detergent) [AID585, Type: confirmatory]Chain A, Ampc Beta-Lactamase In Complex With 4-Methanesulfonylamino Benzoic Acid [gi:119389684]
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