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CHEMBL77981 (CID 14076674) - Compound BioActivity Data
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BioActivity Outcomes:
Active(2)
 
 
Unspecified(7)
 
 
Top Targets:
Chemokine CXC(1)
 
 
BioAssay Types:
Literature(8)
 
 
 
Confirmatory(1)
 
 
BioActivity Types:
IC50(3)
 
 
 
Ki(1)
 
 
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 9    Data Row: 9   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103277835]
IC50 0.025Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]Interleukin-8 [gi:124359]
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2
[SID103277835]
Ki 2Binding affinity measured on human cytochrome P450 2C9 (CYP2C9) enzyme [AID54405, Type: Literature]
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3
[SID103277835]
IC50 1e+08In vitro inhibition of bovine prostaglandin G/H synthase, using bovine seminal vesicle microsomal preparations; IC50 in umol/L [AID160713, Type: Literature]
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4
[SID103277835]
IC50 1e+08Inhibition of COX (unknown origin) [AID771857, Type: confirmatory]
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5
[SID103277835]
Partition coefficient (logD7.4) [AID23265, Type: Literature]
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6
[SID103277835]
Dissociation constant (pKa) [AID25584, Type: Literature]
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7
[SID103277835]
Inhibition of inflammatory hind paw edema, induced by Mycobacterium butyricum in rats; ED40 in umol/kg po [AID194137, Type: Literature]
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8
[SID103277835]
Cytotoxicity against of human polymorphonuclear leukocytes assessed as cell viability by trypan blue dye exclusion assay [AID426393, Type: Literature]
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9
[SID103277835]
Cytotoxicity against mouse L1.2 cells assessed as cell viability by trypan blue dye exclusion assay [AID426478, Type: Literature]
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