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CHEMBL58150 (CID 13891339) - Compound BioActivity Data
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BioActivity Outcomes:
Active(36)
 
 
Inactive(11)
 
 
Unspecified(22)
 
 
Top Targets:
PAD(22)
 
 
 
 
PAD M(8)
 
 
BioAssay Types:
Literature(43)
 
 
 
 
Confirmatory(6)
 
 
 
BioActivity Types:
IC50(8)
 
 
EC50(2)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 54    Data Row: 69   Total Pages: 4   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103245838]
IC50 0.07Inhibition of recombinant wild-type PAD1 (unknown origin) using N-alpha-Benzoyl-L-arginine amide as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay [AID1069622, Type: Literature]Protein-arginine deiminase type-1 [gi:56757695]
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2
[SID118043677]
Average IC50 [PAD1] 0.07Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 17 against PAD1-4 [AID588490_1, Type: confirmatory]protein-arginine deiminase type-1 [Homo sapiens] [gi:122056685]
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3
[SID103245838]
IC50 0.2Inhibition of recombinant wild-type PAD2 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay [AID1069621, Type: Literature]Protein-arginine deiminase type-2 [gi:7531171]
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4
[SID118043677]
Average IC50 [PAD2] 0.2Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 17 against PAD1-4 [AID588490_2, Type: confirmatory]protein-arginine deiminase type-2 [Homo sapiens] [gi:122939159]
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5
[SID118043677]
Average IC50 [PAD4] 0.24Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 17 against PAD1-4 [AID588490_4, Type: confirmatory]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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6
[SID103245838]
IC50 0.24Inhibition of recombinant wild-type PAD4 (unknown origin) using N-alpha-Benzoyl-L-arginine ethyl ester as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay [AID1069619, Type: Literature]Protein-arginine deiminase type-4 [gi:296439260]
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7
[SID118043677]
Average IC50 [PAD3] 0.71Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 17 against PAD1-4 [AID588490_3, Type: confirmatory]protein-arginine deiminase type-3 [Homo sapiens] [gi:122939161]
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8
[SID103245838]
IC50 0.71Inhibition of recombinant wild-type PAD3 (unknown origin) using N-alpha-Benzoyl-L-arginine amide as substrate preincubated for 15 mins followed by substrate addition measured after 15 mins by COLDER assay [AID1069620, Type: Literature]Protein-arginine deiminase type-3 [gi:56757696]
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9
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_3, Type: other]protein-arginine deiminase type-3 [Homo sapiens] [gi:122939161]
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10
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate dialysis assay to assess binding mode of test compounds to PADs 1-3 [AID651861_3, Type: other]protein-arginine deiminase type-3 [Homo sapiens] [gi:122939161]
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11
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to determine rate constants of test compounds for PAD 3 inactivation [AID651866, Type: other]protein-arginine deiminase type-3 [Homo sapiens] [gi:122939161]
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12
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to identify inhibitors of PAD4 [AID588559, Type: other]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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13
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_4, Type: other]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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14
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate dialysis assay to assess binding mode of test compounds to PAD4 [AID651627, Type: other]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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15
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to determine rate constants of test compounds for PAD 4 inactivation [AID651867, Type: other]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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16
[SID103245838]
Binding affinity to recombinant wild-type PAD4 (unknown origin) assessed as mass shift of enzyme at 1:10 enzyme to compound ratio preincubated for 1 hr followed by overnight dialysis in double distilled water by MALDI mass spectrometric analysis in presence of catalase [AID1069598, Type: Literature]Protein-arginine deiminase type-4 [gi:296439260]
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17
[SID103245838]
Binding affinity to recombinant wild-type PAD4 (unknown origin) assessed as mass shift of enzyme at 1:10 enzyme to compound ratio preincubated for 1 hr followed by overnight dialysis in double distilled water by MALDI mass spectrometric analysis in presence of superoxide dismutase [AID1069600, Type: Literature]Protein-arginine deiminase type-4 [gi:296439260]
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18
[SID103245838]
Binding affinity to recombinant wild-type PAD4 (unknown origin) assessed as mass shift of enzyme at 1:10 enzyme to compound ratio preincubated for 1 hr followed by overnight dialysis in double distilled water by MALDI mass spectrometric analysis [AID1069604, Type: Literature]Protein-arginine deiminase type-4 [gi:296439260]
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19
[SID103245838]
Competitive inhibition of recombinant wild-type PAD4 (unknown origin) at 1 to 50 uM by fluorescence polarization-ABPP assay in presence of RFA [AID1069606, Type: Literature]Protein-arginine deiminase type-4 [gi:296439260]
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20
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_2, Type: other]protein-arginine deiminase type-2 [Homo sapiens] [gi:122939159]
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