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AGN-PC-00OCKQ (CID 13891339) - Compound BioActivity Data
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BioActivity Outcomes:
Active(20)
 
 
Inactive(6)
 
 
Unspecified(12)
 
 
Top Targets:
PAD(9)
 
 
PAD M(8)
 
 
BioAssay Types:
Literature(12)
 
 
Confirmatory(6)
 
 
 
BioActivity Types:
IC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 23    Data Row: 38   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID118043677]
Average IC50 [PAD1] 0.07Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 17 against PAD1-4 [AID588490_1, Type: confirmatory]protein-arginine deiminase type-1 [Homo sapiens] [gi:122056685]
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2
[SID118043677]
Average IC50 [PAD2] 0.2Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 17 against PAD1-4 [AID588490_2, Type: confirmatory]protein-arginine deiminase type-2 [Homo sapiens] [gi:122939159]
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3
[SID118043677]
Average IC50 [PAD4] 0.24Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 17 against PAD1-4 [AID588490_4, Type: confirmatory]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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4
[SID118043677]
Average IC50 [PAD3] 0.71Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 17 against PAD1-4 [AID588490_3, Type: confirmatory]protein-arginine deiminase type-3 [Homo sapiens] [gi:122939161]
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5
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to identify inhibitors of PAD4 [AID588559, Type: other]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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6
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_4, Type: other]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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7
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate dialysis assay to assess binding mode of test compounds to PAD4 [AID651627, Type: other]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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8
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to determine rate constants of test compounds for PAD 4 inactivation [AID651867, Type: other]protein-arginine deiminase type-4 [Homo sapiens] [gi:216548487]
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9
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate dialysis assay to assess binding mode of test compounds to PADs 1-3 [AID651861_2, Type: other]protein-arginine deiminase type-2 [Homo sapiens] [gi:122939159]
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10
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_2, Type: other]protein-arginine deiminase type-2 [Homo sapiens] [gi:122939159]
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11
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to determine rate constants of test compounds for PAD 2 inactivation [AID651865, Type: other]protein-arginine deiminase type-2 [Homo sapiens] [gi:122939159]
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12
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to determine rate constants of test compounds for PAD 3 inactivation [AID651866, Type: other]protein-arginine deiminase type-3 [Homo sapiens] [gi:122939161]
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13
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_3, Type: other]protein-arginine deiminase type-3 [Homo sapiens] [gi:122939161]
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14
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate dialysis assay to assess binding mode of test compounds to PADs 1-3 [AID651861_3, Type: other]protein-arginine deiminase type-3 [Homo sapiens] [gi:122939161]
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15
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to assess potency of compound 17 against PAD1-4 [AID588490, Type: confirmatory]
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16
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate dialysis assay to assess binding mode of test compounds to PADs 1-3 [AID651861, Type: other]
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17
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560, Type: other]
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18
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate assay to determine rate constants of test compounds for PAD 1 inactivation [AID651868, Type: other]protein-arginine deiminase type-1 [Homo sapiens] [gi:122056685]
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19
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of PAD4: colorimetric biochemical substrate assay to identify inhibitors of PADs 1-4 [AID588560_1, Type: other]protein-arginine deiminase type-1 [Homo sapiens] [gi:122056685]
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20
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): colorimetric biochemical substrate dialysis assay to assess binding mode of test compounds to PADs 1-3 [AID651861_1, Type: other]protein-arginine deiminase type-1 [Homo sapiens] [gi:122056685]
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21
[SID103245838]
Cytotoxicity against mouse melanoma cell culture(B-16) [AID38039, Type: Literature]
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22
[SID103245838]
Cytotoxicity against human lymphoblastic leukemia cell culture (CCRF-CEM) [AID44019, Type: Literature]
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23
[SID103245838]
Antimicrobial activity was determined against Candida albicans ATCC 10231 [AID44988, Type: Literature]
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24
[SID103245838]
Antimicrobial activity was determined against Escherichia coli ATCC 9637 [AID69959, Type: Literature]
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25
[SID103245838]
Cytotoxicity against human epidermoid carcinoma of the nasopharynx (9KB) [AID70061, Type: Literature]
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26
[SID103245838]
Antimicrobial activity was determined against Klebsiella pneumoniae ATCC 10031 [AID94298, Type: Literature]
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27
[SID103245838]
Cytotoxicity against mouse lymphoblastic leukemia cell culture (L-1210) [AID94733, Type: Literature]
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28
[SID103245838]
Antimicrobial activity was determined against Mycobacterium smegmatis ATCC 607 [AID144440, Type: Literature]
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29
[SID103245838]
Cytotoxicity against P388 mouse leukemia cell culture (9PS(P388)) [AID152700, Type: Literature]
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30
[SID103245838]
Antimicrobial activity was determined against Pseudomonas aeruginosa ATCC 27853 cells [AID164400, Type: Literature]
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31
[SID103245838]
Antimicrobial activity was determined against Salmonella gallinarum ATCC 9184 [AID200512, Type: Literature]
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32
[SID103245838]
Antimicrobial activity was determined against Staphylococcus aureus ATCC 13709 [AID207620, Type: Literature]
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33
[SID118043677]
CC50 26.5Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): cell-based absorbance-based assay to assess cytotoxicity of test compounds [AID651887, Type: confirmatory]
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34
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) assessment of compound selectivity [AID651628, Type: other]
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35
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) assessment of compound selectivity [AID651628_1, Type: other]
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36
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) assessment of compound selectivity [AID651628_2, Type: other]
View
37
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) assessment of compound selectivity [AID651628_3, Type: other]
View
38
[SID118043677]
Late stage assay provider results from the probe development effort to identify inhibitors of Protein Arginine Deiminase 4 (PAD4): fluorescence-based biochemical gel-based competitive Activity-Based Protein Profiling (ABPP) assessment of compound selectivity [AID651628_4, Type: other]
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