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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (CID 1388) - Compound BioActivity Data
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BioActivity Outcomes:
Active(3)
 
 
Inactive(1)
 
 
Unspecified(111)
 
 
Top Targets:
NAD binding 8(22)
 
 
 
7TM GPCR Srsx(8)
 
 
7TM GPCR Srx(8)
 
 
MFS(5)
 
 
NOS oxygenase..(4)
 
 
BioAssay Types:
Literature(114)
 
 
 
BioActivity Types:
Ki(4)
 
 
IC50(4)
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 99    Data Row: 115   Total Pages: 6   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103192001]
Km 0.39Kinetic parameter KM (nM) for the MAO-B catalyzed oxidation of the compound. [AID17444, Type: Literature]
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2
[SID103192001]
Inhibition of human recombinant MAOA expressed in insect cells assessed as oxidation of kynuramine substrate at 50 uM measured after additional enzyme added after 120 mins incubation [AID641928, Type: Literature]Amine oxidase [flavin-containing] A [gi:113978]
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3
[SID103192001]
Inhibition of human recombinant MAOA expressed in insect cells assessed as oxidation of kynuramine substrate at 50 uM measured after additional substrate added after 90 mins incubation [AID641842, Type: Literature]Amine oxidase [flavin-containing] A [gi:113978]
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4
[SID103192001]
Km 81.8Activity at baboon liver mitochondrial MAO-B assessed as initial rate of H2O2 production after 12.5 mins [AID488092, Type: Literature]
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5
[SID103192001]
Km 90separate experiments, n=5) [AID27333, Type: Literature]
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6
[SID103192001]
Ki 100Binding affinity against monoamine oxidase-B (MAO-B) [AID126505, Type: Literature]
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7
[SID103192001]
Km 134Kinetic constant (Km) determined in rat brain mitochondria [AID195852, Type: Literature]
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8
[SID103192001]
Km 140Michaelis-Menten constant against MAO A. [AID102566, Type: Literature]
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9
[SID103192001]
Km 140Oxidation by human mono-amine oxidase MAO-A [AID102736, Type: Literature]Amine oxidase [flavin-containing] A [gi:113978]
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10
[SID103192001]
Km 191Michaelis-Menten constant for Monoamine oxidase B catalyzed oxidation (KM). [AID126380, Type: Literature]Amine oxidase [flavin-containing] B [gi:124028638]
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11
[SID103192001]
Km 200Km against bovine liver Monoamine oxidase B [AID126515, Type: Literature]Amine oxidase [flavin-containing] B [gi:124028638]
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12
[SID103192001]
Ki 280Inhibition of human liver monoamine oxidase was determined [AID127329, Type: Literature]
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13
[SID103192001]
Km 390Michaelis-Menten constant was measured against monoamine oxidase B (MAO-B) from beef liver [AID126381, Type: Literature]
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14
[SID103192001]
Km 390Tested against Monoamine oxidase B enzyme from bovine liver mitochondria [AID126383, Type: Literature]
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15
[SID103192001]
Km 390Michaelis-Menten constant against MAO B. [AID102575, Type: Literature]Amine oxidase [flavin-containing] B [gi:124028638]
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16
[SID103192001]
Km 390Oxidation by bovine mono-amine oxidase B MAO-B [AID102891, Type: Literature]Amine oxidase [flavin-containing] B [gi:124028638]
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17
[SID103192001]
Ki 500Inactivation of monoamine oxidase measured as kinetic constant, KI at 1-5 conc range [AID127323, Type: Literature]
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18
[SID103192001]
Km 654Michaelis-Menten constant for Monoamine oxidase A catalyzed oxidation (Km) [AID125559, Type: Literature]Amine oxidase [flavin-containing] A [gi:113978]
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19
[SID103192001]
IC50 3000Inhibitory activity against human liver Dihydrodipicolinate reductase (DHPR) [AID56917, Type: Literature]
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20
[SID103192001]
IC50 4600Inhibitory activity against rat striatal synaptosomes Dihydrodipicolinate reductase (DHPR) [AID56920, Type: Literature]
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