SureCN6243911 (CID 13752584) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(1)
 
 
Unspecified(8)
 
 
Top Targets:
prostaglandin..(3)
 
 
Chemokine CXC(1)
 
 
BioAssay Types:
Literature(9)
 
 
 
BioActivity Types:
IC50(2)
 
 
 
SAR
Target summary
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Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 9    Data Row: 9   Total Pages: 1   
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103277555]
IC50 0.4Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]Interleukin-8 [gi:124359]
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2
[SID103277555]
IC50 0.4Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]Interleukin-8 [gi:124359]
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3
[SID103277555]
IC50 0.4Inhibition of CXCL8-induced chemotaxis in human polymorphonuclear leukocyte pretreated for 15 mins measured after 4 hrs by cell migration assay [AID426392, Type: Literature]Interleukin-8 [gi:124359]
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4
[SID103277555]
IC50 2.04174e+08In vitro inhibition of bovine prostaglandin G/H synthase, using bovine seminal vesicle microsomal preparations; IC50 in umol/L [AID160713, Type: Literature]
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5
[SID103277555]
 Partition coefficient (logD7.4) [AID23265, Type: Literature]
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6
[SID103277555]
 Cytotoxicity against mouse L1.2 cells assessed as cell viability by trypan blue dye exclusion assay [AID426478, Type: Literature]
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7
[SID103277555]
 Cytotoxicity against of human polymorphonuclear leukocytes assessed as cell viability by trypan blue dye exclusion assay [AID426393, Type: Literature]
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8
[SID103277555]
 Inhibition of inflammatory hind paw edema, induced by Mycobacterium butyricum in rats; ED40 in umol/kg po [AID194137, Type: Literature]
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9
[SID103277555]
 Inhibition of human COX2 at 4 uM for 17 mins pre-incubated before addition of [1-14C]arachidonic acid [AID325053, Type: Literature]Prostaglandin G/H synthase 2 [gi:3915797]
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10
[SID103277555]
 Inhibition of mouse COX2 at 4 uM for 17 mins pre-incubated before addition of [1-14C]arachidonic acid [AID325052, Type: Literature]Prostaglandin G/H synthase 2 [gi:548483]
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11
[SID103277555]
 Inhibition of ovine COX1 at 4 uM for 17 mins pre-incubated before addition of [1-14C]arachidonic acid [AID325051, Type: Literature]Prostaglandin G/H synthase 1 [gi:548481]
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