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methylparaoxon (CID 13708) - Compound BioActivity Data
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BioActivity Outcomes:
Active(7)
 
 
Inactive(85)
 
 
Inconclusive(35)
 
 
Unspecified(10)
 
 
Top Targets:
NR LBD PPAR(13)
 
 
 
 
NR LBD AR(9)
 
 
 
 
NR LBD ER(9)
 
 
 
NR LBD TR(7)
 
 
 
NR LBD Fxr(6)
 
 
 
 
BioAssay Types:
Confirmatory(93)
 
 
 
 
Summary(24)
 
 
 
 
Literature(11)
 
 
 
BioActivity Types:
Potency(111)
 
 
 
 
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 129    Data Row: 137   Total Pages: 7   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID144212326]
Potency-Replicate_1 17.3739qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway [AID743191, Type: confirmatory]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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2
[SID144212326]
Ratio Potency (uM) 19.4938qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway: Summary [AID743063, Type: summary]AR protein [Homo sapiens] [gi:124375976]
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3
[SID144212326]
Potency-Replicate_1 34.3762qHTS assay to identify aromatase inhibitors [AID743083, Type: confirmatory]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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4
[SID144212326]
Potency-Replicate_1 61.1306qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against isogenic chicken DT40 cell lines with known DNA damage response pathways - Rev3 mutant cell line [AID743014, Type: confirmatory]
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5
[SID144212326]
qHTS assay to identify aromatase inhibitors: Summary [AID743139, Type: summary]cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a [Homo sapiens] [gi:119597822]
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6
[SID144212326]
qHTS assay to identify small molecule antagonists of the peroxisome proliferator-activated receptor gamma (PPARg) signaling pathway: Summary [AID743199, Type: summary]peroxisome proliferator activated receptor gamma [Homo sapiens] [gi:216409692]
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7
[SID144212326]
qHTS assay to identify small molecule antagonists of the farnesoid-X-receptor (FXR) signaling pathway: Summary [AID743240, Type: summary]farnesoid X nuclear receptor [Homo sapiens] [gi:325495553]
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8
[SID103192309]
Km 9500Kinetic constant Km from initial velocity assay against Organophosphorus acid anhydrolase from Alteromonas sp. JD6.5 [AID150557, Type: Literature]
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9
[SID103192309]
Ratio of kinetic constant Kcat to Km from initial velocity assay against OPAA from Alteromonas sp. JD6.5 [AID227956, Type: Literature]
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10
[SID103192309]
Partition coefficient (logP) [AID23272, Type: Literature]
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11
[SID103192309]
Kinetic constant Kcat from initial velocity assay against Organophosphorus acid anhydrolase from Alteromonas sp. JD6.5 [AID150556, Type: Literature]
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12
[SID26757320]
qHTS assay for identifying genotoxic compounds that show differential cytotoxicity against a panel of isogenic chicken DT40 cell lines with known DNA damage response pathways [AID651838, Type: other]
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13
[SID103192309]
Resistance index, ratio of bimolecular rate constant Ki for AChE in rganophosphate-resistant clone of Schizaphis graminum OR2 to bimolecular rate constant Ki for AChE in organophosphate-susceptible clone of Schizaphis graminum OSS [AID1101163, Type: Literature]Acetylcholinesterase [gi:75021745]
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14
[SID103192309]
Resistance index, ratio of bimolecular rate constant Ki for AChE in rganophosphate-resistant clone of Schizaphis graminum OR1 to bimolecular rate constant Ki for AChE in organophosphate-susceptible clone of Schizaphis graminum OSS [AID1101164, Type: Literature]Acetylcholinesterase [gi:75021745]
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15
[SID103192309]
Inhibition of AChE in organophosphate-resistant clone of Schizaphis graminum OR2 adult or last-instar nymphs homogenates assessed as bimolecular rate constant pre-incubated with compound for 2 min at 25 degC before addition of ATC and DTNB solution [AID1101165, Type: Literature]Acetylcholinesterase [gi:75021745]
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16
[SID103192309]
Inhibition of AChE in organophosphate-resistant clone of Schizaphis graminum OR1 adult or last-instar nymphs homogenates assessed as bimolecular rate constant pre-incubated with compound for 2 min at 25 degC before addition of ATC and DTNB solution [AID1101166, Type: Literature]Acetylcholinesterase [gi:75021745]
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17
[SID103192309]
Inhibition of AChE in organophosphate-susceptible clone of Schizaphis graminum OSS adult or last-instar nymphs homogenates assessed as bimolecular rate constant pre-incubated with compound for 2 min at 25 degC before addition of ATC and DTNB solution [AID1101167, Type: Literature]Acetylcholinesterase [gi:75021745]
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18
[SID26757320]
Potency qHTS assay for small molecule agonists of androgen receptor signaling [AID588515, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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19
[SID26757320]
Potency qHTS assay for small molecule antagonists of androgen receptor signaling [AID588516, Type: confirmatory]AR protein [Homo sapiens] [gi:124375976]
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20
[SID26757320]
Potency qHTS for Inhibitors of the Interaction of Thyroid Hormone Receptor and Steroid Receptor Coregulator 2 [AID1469, Type: confirmatory]thyroid hormone receptor beta [Homo sapiens] [gi:189491771]
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