Aminolevulinic Acid (CID 137) - BioAssay Data Summary for Compound
.
BioActivity Outcomes:
Active(12)
 
 
Inactive(396)
 
 
Inconclusive(3)
 
 
Unspecified(71)
 
 
Top Targets:
7TM GPCR Srx(15)
 
 
7TM GPCR Srsx(6)
 
 
TRP 2(5)
 
 
alkPPc(4)
 
 
Peptidase C48(4)
 
 
BioAssay Types:
Screening(295)
 
 
 
Confirmatory(91)
 
 
 
 
Literature(81)
 
 
 
 
BioActivity Types:
Potency(78)
 
 
 
 
IC50(18)
 
 
 
 
Ki(4)
 
 
SAR
Target summary
Data download

Chemical Probe    Active    Inactive    Inconclusive    Unspecified   

Total Bioassays: 482    Data Row: 482   Total Pages: 10   Display: Page     
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#SubstanceActivityBioAssayTargetLinks
OutcomeTypeValue [μM]
1
[SID103182993]
IC50 12.9Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method [AID406571, Type: Literature]Gamma-aminobutyric acid receptor subunit rho-1 [gi:223590210]
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2
[SID103182993]
IC50 12.9Antagonist activity at human GABAc Rho1 receptor expressed in Xenopus oocytes assessed as whole cell current production by two electrode voltage clamp method [AID406571, Type: Literature]Gamma-aminobutyric acid receptor subunit rho-1 [gi:223590210]
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3
[SID103182993]
 Antibacterial activity against Escherichia coli K-12 assessed as reduction in microbial viability incubated at 0.1 mM followed by irradiation at 120 J.cm2 light [AID519379, Type: Literature]
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4
[SID103182993]
 Antibacterial activity against Escherichia coli K-12 assessed as reduction in microbial viability incubated at 40 mM followed by irradiation at 120 J.cm2 light [AID519380, Type: Literature]
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5
[SID103182993]
 Induction of photoactive porphyrins in Escherichia coli K-12 exposed to irradiation at 120 J.cm2 light by HPLC [AID519381, Type: Literature]
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6
[SID103182993]
 Induction of photoactive porphyrins in Escherichia coli K-12 assessed as uroporphyrin level exposed to irradiation at 120 J.cm2 light by HPLC [AID519382, Type: Literature]
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7
[SID103182993]
 Induction of photoactive porphyrins in Escherichia coli K-12 assessed as protoporphyrin level exposed to irradiation at 120 J.cm2 light by HPLC [AID519383, Type: Literature]
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8
[SID103182993]
 Antibacterial activity against Escherichia coli K-12 assessed as reduction in microbial viability incubated at 40 mM for 4 hrs under dark condition [AID519389, Type: Literature]
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9
[SID56322917]
 Aqueous Solubility from MLSMR Stock Solutions [AID1996, Type: other]
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10
[SID103182993]
 Increase in ROS production in human U251 cells at 100 uM after 4 hrs by FACS [AID347396, Type: Literature]
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11
[SID103182993]
 Increase in heme level in human U251 cells assessed as porphobilinogen deaminase level at 100 uM after 2 hrs by western blot in presence of cycloheximide [AID347405, Type: Literature]
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12
[SID103182993]
 Induction of apoptosis in human U251 cells assessed as increase in full length caspase 8 level after 24 hrs by western blot [AID347584, Type: Literature]
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13
[SID103182993]
 Inhibition of 26S proteasome activity in human U251 cells at 1 mM after 48 hrs [AID347411, Type: Literature]
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14
[SID103182993]
Ki 230TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT2-expressing LLC-PK1 cells [AID681124, Type: other]Solute carrier family 15 member 2 [gi:2499990]
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15
[SID103182993]
Km 253The Michaelis-Menten rate of reaction catalyzed by ALA dehydratase from Bacillus subtilis measured spectrophotometrically [AID31307, Type: other]
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16
[SID103182993]
Ki 790Inhibition constant (Ki) for human intestinal peptide carrier [AID92023, Type: Literature]
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17
[SID103182993]
Ki 960Inhibitory activity against porcine kidney prolidase [AID162623, Type: other]
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18
[SID103182993]
IC50 1570Cytotoxicity against human HL60 cells after 72 hrs by MTT assay [AID347393, Type: Literature]
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19
[SID103182993]
IC50 1735Cytotoxicity against human MCF7 cells after 72 hrs by Hoechst test [AID347394, Type: Literature]
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20
[SID103182993]
Ki 2200TP_TRANSPORTER: inhibition of Gly-Sar uptake in PEPT1-expressing LLC-PK1 cells [AID681125, Type: other]Solute carrier family 15 member 1 [gi:1730492]
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21
[SID103182993]
IC50 2665Cytotoxicity against human U251 cells after 72 hrs by Hoechst test [AID347392, Type: Literature]
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22
[SID103182993]
IC50 2715Antiproliferative activity against human U251 cells assessed as PpIX release pretreated 72 hrs before 360-410 nm light photosensitization measured after 48 hrs by Hoechst test [AID347409, Type: Literature]
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23
[SID103182993]
IC50 2719Antiproliferative activity against human U251 cells assessed as PpIX release after 72 hrs by Hoechst test [AID347408, Type: Literature]
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24
[SID103182993]
IC50 3475Cytotoxicity against human MCF7/DX cells after 72 hrs by Hoechst test [AID347395, Type: Literature]
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25
[SID103182993]
 Increase in protoporphyrin 9 levels in human U251 cells at 100 uM after 24 hrs relative to control [AID347406, Type: Literature]
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26
[SID103182993]
 Increase in protoporphyrin 9 levels in human U251 cells at 200 uM after 24 hrs relative to control [AID347407, Type: Literature]
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27
[SID103182993]
 Increase in heme level in human U251 cells at 100 uM after 48 hrs by western blot relative to control [AID347403, Type: Literature]
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28
[SID103182993]
 Increase in heme level in human U251 cells assessed as porphobilinogen deaminase level at 100 uM after 2 hrs by western blot relative to control [AID347404, Type: Literature]
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29
[SID103182993]
 Retention of porphobilinogen synthase activity in presence of 0.3 uM of the compound [AID160990, Type: other]
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30
[SID103182993]
 Rate of reaction catalyzed by ALA dehydratase from Bacillus subtilis measured spectrophotometrically [AID31308, Type: other]
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31
[SID103182993]
 isotope effect on rate of reaction catalyzed by ALA dehydratase from Bacillus subtilis were measured spectrophotometrically [AID31309, Type: other]
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32
[SID103182993]
 isotope effect on rate of reaction catalyzed by ALA dehydratase from Bacillus subtilis were measured spectrophotometrically [AID31310, Type: other]
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33
[SID103182993]
 Drug uptake in mouse PAM212 cells assessed as intracellular 5-aminolaevulinic acid level per mg of protein at 0.1 mM after 4 hrs [AID371985, Type: Literature]
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34
[SID103182993]
 Drug uptake in mouse PAM212 cells assessed as PpIX production per mg of protein at 0.1 mM after 4 hrs [AID371986, Type: Literature]
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35
[SID103182993]
 Drug uptake in mouse PAM212 cells assessed as intracellular 5-aminolaevulinic acid level per mg of protein at 1 mM after 4 hrs [AID371987, Type: Literature]
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36
[SID103182993]
 Drug uptake in mouse PAM212 cells assessed as PpIX production per mg of protein at 1 mM after 4 hrs [AID371988, Type: Literature]
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37
[SID103182993]
 Drug uptake in human A549 cells assessed as intracellular 5-aminolaevulinic acid level per mg of protein at 0.1 mM after 4 hrs [AID371989, Type: Literature]
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38
[SID103182993]
 Drug uptake in human A549 cells assessed as PpIX production per mg of protein at 0.1 mM after 4 hrs [AID371990, Type: Literature]
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39
[SID103182993]
 Drug uptake in human Caco-2 cells assessed as intracellular 5-aminolaevulinic acid level per mg of protein at 1 mM after 4 hrs [AID371991, Type: Literature]
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40
[SID103182993]
 Drug uptake in human Caco-2 cells assessed as PpIX production per mg of protein at 1 mM after 4 hrs [AID371992, Type: Literature]
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41
[SID103182993]
 Phototoxicity against mouse PAM212 cells assessed as cell viability at 0.1 mM after 4 hrs irradiated with 2.5 J/cm2 blue light by MTT assay relative to control [AID371993, Type: Literature]
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42
[SID103182993]
 Antibacterial activity against Escherichia coli K-12 assessed as microbial survival fraction incubated at 0.1 mM followed by irradiation at 120 J.cm2 light relative to untreated control [AID519391, Type: Literature]
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43
[SID103182993]
 Antibacterial activity against Escherichia coli Ti05 assessed as microbial survival fraction incubated at 1 mM followed by irradiation at 120 J.cm2 light relative to untreated control [AID519392, Type: Literature]
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44
[SID103182993]
 Antibacterial activity against Pseudomonas aeruginosa assessed as microbial survival fraction incubated at 1 mM followed by irradiation at 120 J.cm2 light relative to untreated control [AID519393, Type: Literature]
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45
[SID103182993]
 Antibacterial activity against methicillin resistant Staphylococcus aureus assessed as microbial survival fraction incubated at 10 mM followed by irradiation at 120 J.cm2 light relative to untreated control [AID519394, Type: Literature]
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46
[SID103182993]
 Induction of photoactive porphyrins in Escherichia coli K-12 assessed as porphyrin level per 10'-6 CFU microbial load incubated at 0.1 mM followed by irradiation at 120 J.cm2 light relative to untreated control [AID519395, Type: Literature]
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47
[SID103182993]
 Induction of photoactive porphyrins in Escherichia coli Ti05 assessed as porphyrin level per 10'-6 CFU microbial load incubated at 1 mM followed by irradiation at 120 J.cm2 light relative to untreated control [AID519396, Type: Literature]
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48
[SID103182993]
 Induction of photoactive porphyrins in Pseudomonas aeruginosa assessed as porphyrin level per 10'-6 CFU microbial load incubated at 1 mM followed by irradiation at 120 J.cm2 light relative to untreated control [AID519397, Type: Literature]
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49
[SID103182993]
 Induction of photoactive porphyrins in methicillin resistant Staphylococcus aureus assessed as porphyrin level per 10'-6 CFU microbial load incubated at 10 mM followed by irradiation at 120 J.cm2 light relative to untreated control [AID519398, Type: Literature]
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50
[SID103182993]
 Drug Induced Liver Injury Prediction System (DILIps) training set; hepatic side effect (HepSE) score for bilirubinemia [AID625279, Type: Literature]
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